MannKind Corporation to Participate in H.C. Wainwright 23rd Annual Global Investment Conference

On September 7, 2021 MannKind Corporation (Nasdaq: MNKD), a company focused on the development and commercialization of inhaled therapeutic products for patients with endocrine and orphan lung diseases, reported that its Chief Executive Officer Michael Castagna, PharmD, will participate in a Fireside Chat at the H.C. Wainwright 23rd Annual Global Investment Conference which will be available on demand starting on September 13, 2021 (Press release, Mannkind, SEP 7, 2021, View Source [SID1234587308]).

Schedule your 30 min Free 1stOncology Demo!
Discover why more than 1,500 members use 1stOncology™ to excel in:

Early/Late Stage Pipeline Development - Target Scouting - Clinical Biomarkers - Indication Selection & Expansion - BD&L Contacts - Conference Reports - Combinatorial Drug Settings - Companion Diagnostics - Drug Repositioning - First-in-class Analysis - Competitive Analysis - Deals & Licensing

                  Schedule Your 30 min Free Demo!

Interested parties can access a link to the on demand webcast of the presentation from the Events & Presentations section of the Company’s website at View Source The webcast replay may be accessed at the same location for 14 days.

Greenwich LifeSciences to Participate in Citi’s 16th Annual Biopharma Virtual Conference

On September 7, 2021 Greenwich LifeSciences, Inc. (Nasdaq: GLSI) (the "Company"), a clinical-stage biopharmaceutical company focused on the development of GP2, an immunotherapy to prevent breast cancer recurrences in patients who have previously undergone surgery, reported its participation in Citi’s 16th Annual BioPharma Virtual Conference from September 8-10, 2021 (Press release, Greenwich LifeSciences, SEP 7, 2021, View Source [SID1234587307]). CEO Snehal Patel will participate in one-on-one meetings with qualified members of the investor community who are registered to attend the conference.

Schedule your 30 min Free 1stOncology Demo!
Discover why more than 1,500 members use 1stOncology™ to excel in:

Early/Late Stage Pipeline Development - Target Scouting - Clinical Biomarkers - Indication Selection & Expansion - BD&L Contacts - Conference Reports - Combinatorial Drug Settings - Companion Diagnostics - Drug Repositioning - First-in-class Analysis - Competitive Analysis - Deals & Licensing

                  Schedule Your 30 min Free Demo!

Citi’s 16th Annual BioPharma Conference

Citi’s Biopharma conference is by invitation only and will feature fireside chats and presentations by select large pharma and biotech companies and key opinion leaders in a virtual format. Participating companies will also participate in one-on-one meetings.

About Breast Cancer and HER2/neu Positivity

One in eight U.S. women will develop invasive breast cancer over her lifetime, with approximately 266,000 new breast cancer patients and 3.1 million breast cancer survivors in 2018. HER2/neu (human epidermal growth factor receptor 2) protein is a cell surface receptor protein that is expressed in a variety of common cancers, including in 75% of breast cancers at low (1+), intermediate (2+), and high (3+ or over-expressor) levels.

Lilly Announces Cash Tender Offer for Up to $1.5 Billion Combined Aggregate Principal Amount of Its Outstanding Debt Securities

On September 7, 2021 Eli Lilly and Company (NYSE: LLY) reported that it has commenced a cash tender offer for up to $1.5 billion combined aggregate principal amount (the "Tender Cap") of specified series of its outstanding debt securities (Press release, Eli Lilly, SEP 7, 2021, View Source [SID1234587306]). Pursuant to the tender offer, Lilly is offering to purchase, under certain conditions and subject to certain limitations, its 4.150% Notes due 2059 (the "4.150% Notes"), 3.950% Notes due 2049 (the "3.950% Notes"), 7.125% Notes due 2025 (the "7.125% Notes"), 6.770% Notes due 2036 (the "6.770% Notes"), 5.950% Notes due 2037 (the "5.950% Notes"), 5.550% Notes due 2037 (the "5.550% Notes"), 5.500% Notes due 2027 (the "5.500% Notes"), 4.650% Notes due 2044 (the "4.650% Notes"), 3.950% Notes due 2047 (the "3.950% Notes due 2047"), 3.875% Notes due 2039 (the "3.875% Notes"), 3.700% Notes due 2045 (the "3.700% Notes"), 3.375% Notes due 2029 (the "3.375% Notes"), 3.100% Notes due 2027 (the "3.100% Notes"), 2.750% Notes due 2025 (the "2.750% Notes") and 2.350% Notes due 2022 (the "2.350% Notes") (collectively, the "notes").

Schedule your 30 min Free 1stOncology Demo!
Discover why more than 1,500 members use 1stOncology™ to excel in:

Early/Late Stage Pipeline Development - Target Scouting - Clinical Biomarkers - Indication Selection & Expansion - BD&L Contacts - Conference Reports - Combinatorial Drug Settings - Companion Diagnostics - Drug Repositioning - First-in-class Analysis - Competitive Analysis - Deals & Licensing

                  Schedule Your 30 min Free Demo!

The early tender date and time is 5:00 p.m., New York City time, on September 20, 2021, unless extended. The tender offer is scheduled to expire at 11:59 p.m., New York City time, on October 4, 2021, unless extended or earlier terminated. The terms, conditions and limitations of the tender offer are described in the Offer to Purchase dated as of today’s date.

Holders of notes subject to the tender offer must validly tender and not validly withdraw their notes before the early tender date to be eligible to receive the total consideration (as described below). Only holders that validly tender and do not validly withdraw their notes on or prior to the early tender date will be eligible to receive the early tender premium (as described below). Tendered notes may only be withdrawn on or before 5:00 p.m., New York City time, on September 20, 2021. Notes tendered after the withdrawal date and before the expiration date may not be withdrawn, except in certain limited circumstances where additional withdrawal rights are required by law.

The table below sets forth certain information regarding the notes and the tender offer.

Title of Security

CUSIP No.

Principal
Amount
Outstanding

Acceptance
Priority
Level

Reference U.S.
Treasury Security

Bloomberg
Reference
Page

Fixed Spread

Early
Tender
Premium(1)

4.150% Notes due 2059

532457 BU1

$1,000,000,000

1(2)

2.375% due May 15, 2051

FIT1

80 bps

$30

3.950% Notes due 2049

532457 BT4

$1,500,000,000

2(3)

2.375% due May 15, 2051

FIT1

70 bps

$30

7.125% Notes due 2025

532457 AM0

$229,692,000

3

0.750% due August 31, 2026

FIT1

15 bps

$30

6.770% Notes due 2036

532457 AP3

$174,445,000

4

1.250% due August 15, 2031

FIT1

105 bps

$30

5.950% Notes due 2037

532457 BC1

$284,112,000

5

1.750% due August 15, 2041

FIT1

55 bps

$30

5.550% Notes due 2037

532457 BA5

$476,152,000

6

1.750% due August 15, 2041

FIT1

50 bps

$30

5.500% Notes due 2027

532457 AZ1

$377,505,000

7

0.750% due August 31, 2026

FIT1

40 bps

$30

4.650% Notes due 2044

532457 BG2

$43,016,000

8

1.750% due August 15, 2041

FIT1

75 bps

$30

3.950% Notes due 2047

532457 BR8

$436,129,000

9

2.375% due May 15, 2051

FIT1

70 bps

$30

3.875% Notes due 2039

532457 BS6

$360,745,000

10

1.750% due August 15, 2041

FIT1

45 bps

$30

3.700% Notes due 2045

532457 BJ6

$412,467,000

11

2.375% due May 15, 2051

FIT1

65 bps

$30

3.375% Notes due 2029

532457 BV9

$1,150,000,000

12

1.250% due August 15, 2031

FIT1

15 bps

$30

3.100% Notes due 2027

532457 BP2

$401,450,000

13

0.750% due August 31, 2026

FIT1

35 bps

$30

2.750% Notes due 2025

532457 BH0

$560,646,000

14

0.750% due August 31, 2026

FIT1

0 bps

$30

2.350% Notes due 2022

532457 BQ0

$750,000,000

15

1.750% due May 15, 2022

FIT3

10 bps

$30

(1) As set forth in the Offer to Purchase, an early tender premium of $30 per $1,000 principal amount of notes that are tendered and accepted for purchase in the tender offer (the "Early Tender Premium") will be paid to holders of notes that are validly tendered and not validly withdrawn on or before the early tender date.

(2) The maximum principal amount of 4.150% Notes that the Company will accept for purchase pursuant to the tender offer is $350,000,000 (the "4.150% Note Cap").

(3) The maximum principal amount of 3.950% Notes that the Company will accept for purchase pursuant to the tender offer is $525,000,000 (the "3.950% Note Cap" and, together with the 4.150% Note Cap, the "Note Caps").

Subject to the Tender Cap, validly tendered notes will be accepted for purchase in the order of the acceptance priority levels set forth in the table above, except that the aggregate principal amount of the 4.150% Notes accepted will not exceed the 4.150% Note Cap and the aggregate principal amount of 3.950% Notes accepted will not exceed the 3.950% Note Cap. Lilly reserves the right, but is not obligated, to increase the Tender Cap or any of the Note Caps. Tenders of the 2.350% Notes, the 2.750% Notes, the 5.500% Notes, the 3.100% Notes, the 3.375% Notes, the 5.950% Notes, the 5.550% Notes, the 3.875% Notes, the 4.650% Notes, the 3.700% Notes, the 3.950% Notes due 2047, the 3.950% Notes and the 4.150% Notes will be accepted only in principal amounts equal to $2,000 and integral multiples of $1,000 in excess thereof. Tenders of the 7.125% Notes and the 6.770% Notes will be accepted only in principal amounts equal to $1,000 and integral multiples of $1,000 thereof.

The total consideration for each $1,000 principal amount of notes tendered and accepted for payment by Lilly pursuant to the tender offer will be determined in the manner described in the Offer to Purchase by reference to a fixed spread specified in the table above for each series of the notes and the applicable reference yield based on the bid-side price of the applicable U.S. Treasury Security specified in the table above, as calculated by the dealer managers for the tender offer at 10:00 a.m., New York City time, on September 21, 2021. Holders of notes who validly tender their notes after the early tender date will, if such notes are accepted for purchase by Lilly, receive the tender consideration, which is equal to the total consideration minus the applicable Early Tender Premium. Accrued and unpaid interest up to, but excluding, the applicable settlement date will be paid in cash on all validly tendered notes accepted and purchased by Lilly in the tender offer.

Lilly reserves the right, but is under no obligation, at any point following the early tender date and before the expiration date of the tender offer, to accept for purchase any notes validly tendered at or prior to the early tender date. The early settlement date will be determined at Lilly’s option and is currently expected to occur on September 22, 2021, assuming the early tender date is not extended. Irrespective of whether Lilly chooses to exercise its option to have an early settlement of the tender offer, Lilly will purchase any remaining notes that have been validly tendered by the expiration date of the tender offer and accepted for purchase (subject to the Tender Cap, the Note Caps, and the application of the acceptance priority levels), promptly following the expiration date of the tender offer.

All notes validly tendered and not validly withdrawn on or before the early tender date having a higher acceptance priority level will be accepted for purchase (subject to the Tender Cap and the Note Caps) before any validly tendered notes having a lower acceptance priority level are accepted for purchase, and all notes validly tendered after the early tender date having a higher acceptance priority level will be accepted for purchase (subject to the Tender Cap and the Note Caps) before any notes tendered after the early tender date having a lower acceptance priority level are accepted for purchase. However, priority will be given to accept for purchase notes validly tendered and not validly withdrawn on or before the early tender date (subject to the Tender Cap and the Note Caps) ahead of other notes tendered after the early tender date, even if such notes tendered after the early tender date have a higher acceptance priority level than notes validly tendered and not validly withdrawn prior to the early tender date.

Notes accepted for purchase in accordance with the terms and conditions of the tender offer may be subject to proration (rounded down to avoid the purchase of notes in a principal amount other than in integral multiples of $1,000), so that Lilly will only accept for purchase notes in an aggregate principal amount up to the Tender Cap, including the maximum amount of 4.150% Notes that may be purchased pursuant to the 4.150% Note Cap and the maximum amount of 3.950% Notes that may be purchased pursuant to the 3.950% Note Cap. If purchasing all of the tendered notes of a series of notes of an applicable acceptance priority level on any settlement date would cause the Tender Cap or, a Note Cap, if applicable, to be exceeded, the amount of that series of notes purchased on that settlement date will be prorated based on the aggregate principal amount of that series of notes tendered in respect of that settlement date such that the Tender Cap and the Note Caps will not be exceeded. Furthermore, if the tender offer is fully subscribed as of the early tender date, holders who validly tender notes after the early tender date will not have their notes accepted for purchase.

The offer for each series of notes is conditioned upon the satisfaction or waiver by Lilly of certain conditions, including the completion of an offering of debt securities by Lilly on terms and conditions satisfactory to Lilly that results in the receipt of net proceeds that, when taken together with cash on hand, is sufficient to pay the consideration for all tendered notes validly tendered (and not validly withdrawn) and accepted for purchase by Lilly, plus related accrued and unpaid interest and fees and expenses.

The offer is not conditioned on the tender or purchase of a minimum principal amount of notes being tendered or on any series of notes being tendered. The offer with respect to one or more series of the notes may be amended, extended, terminated or withdrawn separately.

Lilly has retained BofA Securities, Inc. and Citigroup Global Markets Inc. to serve as lead dealer managers for the tender offer, and Barclays Capital, Inc., BNP Paribas Securities Corp. and Deutsche Bank Securities Inc. to serve as co-dealer managers. Lilly has retained Global Bondholder Services Corporation to serve as tender agent and information agent for the tender offer.

Requests for documents relating to the tender offer may be directed to Global Bondholder Services Corporation by telephone at +1 (866) 470-3900, by email at [email protected] or in writing at 65 Broadway, Suite 404, New York, NY 10006. Questions regarding the tender offer may be directed to BofA Securities, Inc. toll-free at +1 (888) 292-0070 or collect at +1 (980) 387-3907 or to Citigroup Global Markets Inc. toll-free at +1 (800) 558-3745 or collect +1 (212) 723-6106.

This press release is for informational purposes only and is not an offer to purchase, the solicitation of an offer to sell any notes. The tender offer is being made only pursuant to the Offer to Purchase and the information in this press release is qualified by reference to the Offer to Purchase. In any jurisdiction where the laws require the tender offer to be made by a licensed broker or dealer, the tender offer will be deemed made on behalf of Lilly by the dealer managers, or one or more registered brokers or dealers under the laws of such jurisdiction. None of Lilly or its affiliates, their respective boards of directors, the Dealer Managers, Global Bondholder Services Corporation or the trustee with respect to any series of notes is making any recommendation as to whether holders should tender any notes in response to the tender offer, and neither Lilly nor any such other person has authorized any person to make any such recommendation. Holders must make their own decision as to whether to tender any of their notes, and, if so, the principal amount of notes to tender.

In addition, this press release is not an offer to sell or the solicitation of an offer to buy any securities. No offer, solicitation, purchase or sale will be made in any jurisdiction in which such offer, solicitation or sale would be unlawful prior to registration or qualification under the securities laws of any such jurisdiction. Any such securities will be offered only by means of a prospectus, including a prospectus supplement relating to such securities, meeting the requirements of Section 10 of the Securities Act of 1933, as amended.

Ascendis Pharma A/S Announces Upcoming Investor Presentations

On September 7, 2021 Ascendis Pharma A/S (Nasdaq: ASND), a biopharmaceutical company that utilizes its innovative TransCon technologies to potentially create new treatments that make a meaningful difference in patients’ lives, reported that the company will participate in two upcoming investor conferences (Press release, Ascendis Pharma, SEP 7, 2021, View Source [SID1234587305]). Company executives will provide a business overview and update on the company’s programs.

Schedule your 30 min Free 1stOncology Demo!
Discover why more than 1,500 members use 1stOncology™ to excel in:

Early/Late Stage Pipeline Development - Target Scouting - Clinical Biomarkers - Indication Selection & Expansion - BD&L Contacts - Conference Reports - Combinatorial Drug Settings - Companion Diagnostics - Drug Repositioning - First-in-class Analysis - Competitive Analysis - Deals & Licensing

                  Schedule Your 30 min Free Demo!

Details

Event 2021 Virtual Wells Fargo Healthcare Conference
Location Virtual
Date Friday, September 10, 2021
Time 2:40 p.m. Eastern Time

Event Morgan Stanley 19th Annual Global Healthcare Conference
Location Virtual
Date Wednesday, September 15, 2021
Time 12:30 p.m. Eastern Time
A live webcast of the presentations will be available in the Investors and News section of the Ascendis Pharma website at www.ascendispharma.com. A webcast replay will also be available on this website shortly after conclusion of the events for 30 days.

Ascendis Pharma A/S Submits Investigational New Drug Application to Initiate TransCon™ IL-2 ?/? Clinical Program

On September 7, 2021 Ascendis Pharma A/S (Nasdaq: ASND), a biopharmaceutical company using its innovative TransCon technologies to potentially create new treatments to make a meaningful difference in patients’ lives, reported the submission of an investigational new drug (IND) application with the U.S. Food & Drug Administration (FDA) to initiate IL βelieγe (I’ll Believe) Trial, a phase 1/2 clinical trial to evaluate TransCon IL-2 β/γ in patients with advanced cancer (Press release, Ascendis Pharma, SEP 7, 2021, View Source [SID1234587304]). TransCon IL-2 β/γ is an investigational long-acting prodrug designed to improve cancer immunotherapy by sustained exposure to an IL-2 variant that selectively activates the IL-2Rβ/γ, with minimal binding to IL-2Rα.

Schedule your 30 min Free 1stOncology Demo!
Discover why more than 1,500 members use 1stOncology™ to excel in:

Early/Late Stage Pipeline Development - Target Scouting - Clinical Biomarkers - Indication Selection & Expansion - BD&L Contacts - Conference Reports - Combinatorial Drug Settings - Companion Diagnostics - Drug Repositioning - First-in-class Analysis - Competitive Analysis - Deals & Licensing

                  Schedule Your 30 min Free Demo!

"This IND submission for our second clinical stage oncology product candidate represents another major milestone for Ascendis. Our understanding of the biology has guided us in designing a novel parent drug, which we have combined with our clinically validated TransCon platform. We believe this combination has the potential to overcome the known shortcomings of current IL-2 compounds, such as low potency, short half-life and high Cmax. By solving the different elements related to efficacy and safety independently, we believe it will be possible to realize the full potential of the IL-2 pathway and create a potentially best-in-class cancer immunotherapy product," said Kennett Sprogøe, Ph.D., Ascendis Pharma’s Head of Innovation and Research.

About TransCon Technologies

TransCon refers to "transient conjugation." Ascendis Pharma’s proprietary TransCon platform is an innovative technology used to create new therapies that are designed to potentially optimize therapeutic effect, including efficacy, safety, and dosing frequency. TransCon molecules have three components: a parent drug, an inert carrier that protects it, and a linker that temporarily binds the two. When bound, the carrier inactivates and shields the parent drug from clearance. When injected into the body, physiologic conditions (e.g., pH and temperature) initiate the release of the active, unmodified parent drug in a predictable manner, maintaining its original mode of action. TransCon technology can be applied broadly to a protein, peptide or small molecule in multiple therapeutic areas, and can be used systemically or locally.