RAPT Therapeutics to Present at the UBS Global Healthcare Virtual Conference

On May 20, 2021 RAPT Therapeutics, Inc. (Nasdaq: RAPT), a clinical-stage, immunology-based biopharmaceutical company focused on discovering, developing and commercializing oral small molecule therapies for patients with significant unmet needs in oncology and inflammatory diseases, reported that Brian Wong, M.D., Ph.D., President and Chief Executive Officer, will participate in a fireside chat at the UBS Global Healthcare Virtual Conference on Monday, May 24, 2021 at 3:00 pm Eastern Time (Press release, RAPT Therapeutics, MAY 20, 2021, https://investors.rapt.com/news-releases/news-release-details/rapt-therapeutics-present-ubs-global-healthcare-virtual [SID1234585133]).

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To access the live webcast and subsequent archived recording of the company presentation, please visit the RAPT Therapeutics website at https://investors.rapt.com/events-and-presentations.

Rubius Therapeutics to Participate in Jefferies Virtual Healthcare Conference

On May 20, 2021 Rubius Therapeutics, Inc. (Nasdaq: RUBY), a clinical-stage biopharmaceutical company that is genetically engineering red blood cells to create an entirely new class of cellular medicines called Red Cell Therapeutics, reported that Pablo J. Cagnoni, M.D., president and chief executive officer, will participate in a fireside chat at the Jefferies Virtual Healthcare Conference on June 2, 2021, at 4:00 p.m. EDT (Press release, Rubius Therapeutics, MAY 20, 2021, View Source [SID1234584707]).

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A live audio webcast will be available within the Investors & Media section of the Rubius Therapeutics website. An archived replay will be accessible for 90 days following the event.

GeneQuantum Completes C Round for Novel ADC Candidates

On May 20, 2021 GeneQuantum Healthcare (Suzhou) reported that it completed a Series C funding to develop its portfolio of site-specific antibody drug conjugate molecules (Press release, GeneQuantum Healthcare, MAY 20, 2021, View Source [SID1234580472]). According to the company, the C round raised several hundreds of millions of RMB, which puts the funding at least in the $50 million range, but the exact amount was not disclosed. GeneQuantum says it has built a differentiated ADC platform that addresses the major problems of ADC drugs: high heterogeneity, narrow therapeutic window and high manufacturing cost. The Series C was led by China Life Private Equity Investment.

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Indica Labs and Ibex partner to deliver AI-powered clinical workflows for digital pathology

On May 20, 2021 Indica Labs, an industry leader in quantitative digital pathology & image management solutions, and Ibex Medical Analytics, a pioneer in artificial intelligence (AI) based cancer diagnostics, reported an agreement to integrate the Galen AI-based cancer diagnostics platform into the HALO AP digital pathology workflow platform (Press release, Lifescience Newswire, MAY 20, 2021, View Source [SID1234580466]).

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The HALO AP platform was developed by Indica Labs to address the needs of digital Anatomic Pathology labs. The platform can be fully integrated within existing LIS or HIS solutions or can operate as a standalone case and image management system for anatomic pathology. Furthermore, HALO AP supports a full range of tissue-based assays and workflows, including synoptic reporting, tumour boards, secondary consults, quantitative analysis, and AI-assisted workflows. HALO AP is used by some of the largest anatomic pathology laboratories in the world, including NeoGenomics and the National Cancer Institute (NCI).

Ibex’s Galen platform uses strong-AI algorithms that support pathologists in improving the quality of cancer diagnosis and providing productivity-enhancing insights that help reduce turnaround times. Installed in labs worldwide and used as part of everyday clinical practice, Galen routinely detects misdiagnosed and mis-graded cancers in digitized slides, guiding pathologists to areas of cancer in support of a prompt review. In recent clinical studies, the Galen platform demonstrated outstanding clinical outcomes, including the highest accuracy levels reported in the field for prostate cancer, 1- to 2-day reductions in total turnaround time, and 37% productivity gain for pathologists, compared to conventional microscope viewing.
The integration between HALO AP and the Galen platform is designed to enable a seamless experience for the end-user. Galen adds AI-powered cancer detection, case prioritization, grading and other productivity-enhancing insights displayed directly within the HALO AP Platform, so there is no need to use a separate viewer. Where applicable, the data will be communicated with the LIS or HIS system automatically.

"While Indica Labs continues to grow our state-of-the-art AI application pipeline, we also recognize the importance of interoperability with other leaders in this growing field," commented Steven Hashagen, Indica Labs CEO. "A truly seamless integration with Ibex will allow customers to make best-of-breed AI selections without compromising usability."

"Integrated digital pathology and AI workflows are a major driver in supporting pathologists, as they are challenged by ever-increasing workloads and complexity of cancer diagnosis," said Joseph Mossel, CEO and Co-founder of Ibex Medical Analytics. "By joining forces with Indica Labs, we can jointly offer end-to-end solutions enabling pathologists to accelerate adoption of new technologies, strengthen the business case for digitization and improve the quality of cancer care."

OSE Immunotherapeutics and Boehringer Ingelheim Present Positive Phase 1 Results with First-in-Class SIRPα inhibitor BI 765063 in Advanced Solid Tumors at ASCO 2021

On May 20, 2021 OSE Immunotherapeutics (ISIN: FR0012127173; Mnemo: OSE) and its development partner Boehringer Ingelheim reported that acceptance of an upcoming poster presentation at the 2021 American Society of Clinical Oncology (ASCO) (Free ASCO Whitepaper) Annual Meeting, being held June 4 – 8, 2021, covering promising initial data from Phase 1 dose escalation of selective SIRPα inhibitor BI 765063 in patients with advanced solid tumors (Abstract #2623) (Press release, OSE Immunotherapeutics, MAY 20, 2021, View Source [SID1234580464]).

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The data to be presented at ASCO (Free ASCO Whitepaper) 2021 indicate that OSE Immunotherapeutics’ first-in-class signal regulatory protein α (SIRPα) inhibitor BI 765063 was well-tolerated, showed sustained receptor occupancy (RO) saturation and monotherapy activity. Clinical benefit was observed in 45% of patients evaluable per RECIST* criteria. A durable partial response was observed in an advanced hepatocellular carcinoma (HCC) patient, and the on-treatment biopsy of the responder showed an increase in CD8 T-cell infiltration and activation. Furthermore, the on-treatment biopsy also showed an increase in PD-L1 expression on tumor cells. A BI 765063 dose escalation study in combination with Ezabenlimab (PD-1 antagonist) is ongoing and will help determine the recommended dose for further Phase 2 clinical development in patients with advanced solid tumors.

Alexis Peyroles, CEO of OSE Immunotherapeutics commented: "OSE Immunotherapeutics is moving forward to deliver highly innovative, first-in-class and best-in-class compounds. The promising data presented at ASCO (Free ASCO Whitepaper) includes no serious dose limiting toxicities, as well as early evidence of efficacy, suggesting that selective myeloid cell targeting of SIRPα to modulate CD47-dependent inhibition of anti-tumor immunity including the ‘Don’t Eat Me’ axis is a sound therapeutic strategy in solid tumors. These promising data presented at ASCO (Free ASCO Whitepaper) 2021 on BI 765063 confirm the quality of our science and we look forward to continuing to accelerate our clinical development and pipeline diversification over the coming years."

*RECIST: Response Evaluation Criteria in Solid Tumours

PRESENTATION DETAILS

Title: "Safety, pharmacokinetics, efficacy, and preliminary biomarker data of first-in class
BI 765063, a selective SIRPα inhibitor: results of monotherapy dose escalation in phase 1 study in patients with advanced solid tumors"

The abstract #2623 was posted on ASCO (Free ASCO Whitepaper).org on May 19, 2021 at 5:00PM ET and 11:00PM CEST

From June 4th at 3:00PM CEST:
Virtual poster presentation on demand
Poster session: Developmental Therapeutics – Immunotherapy
Presenting Author: Stéphane Champiat, MD, PhD, Institut de Cancérologie, Gustave Roussy, Villejuif