On April 1, 2021 FoRx Therapeutics, a recently incorporated privately-held company developing first-in-class compounds for cancer treatment, reported the appointment of Tarig Bashir as Chief Executive Officer (Press release, FoRx Therapeutics, APR 1, 2021, View Source;utm_medium=rss&utm_campaign=forx-therapeutics-ag-appoints-tarig-bashir-as-chief-executive-officer [SID1234577579]).

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Tarig Bashir, PhD, is a Pharma and Biotech Executive with over 15 years of experience and leadership in cancer drug discovery, translational oncology and external innovation. During his career, he has led and overseen discovery-stage and preclinical oncology portfolios, led strategic partnerships with pharma and academia, and contributed significantly to clinical compound development. Tarig held positions of increasing responsibility in Oncology R&D at Organon/Schering-Plough, Johnson & Johnson and Ipsen. Most recently he was Executive Vice President Discovery at Proteros, where his responsibilities included new company building.
Tarig studied biology at the University of Würzburg and the State University of New York at Albany. He earned his PhD at the German Cancer Research Center (DKFZ) in Heidelberg and conducted his postdoctoral training at the New York University School of Medicine.

On April 1, 2021 Servier, a global pharmaceutical company, reported that it has successfully completed its acquisition of Agios Pharmaceuticals’ commercial, clinical, and research-stage oncology portfolio for up to $2 billion plus royalties (Press release, Servier, APR 1, 2021, View Source [SID1234577571]). The acquisition immediately strengthens Servier’s commercial presence in the U.S. malignant hematology market and provides the potential for long-term growth into the solid tumor space.

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"We are pleased to welcome an exceptionally talented team that will allow us to strengthen our strategic focus in oncology and expand our scientific capabilities in cellular metabolism," said Olivier Laureau, President of Servier. "It is an important milestone in Servier’s oncology strategy as it significantly reinforces the Group’s presence in the U.S. Together, with this expanded team, we remain committed to addressing the unmet needs of patients living with cancer across the globe."

"We appreciate the support of our employees, partners and Agios team in ensuring a seamless integration," said David K. Lee, CEO, Servier Pharmaceuticals. "The addition of TIBSOVO and IDHIFA to our pipeline allows us to expand our oncology leadership capabilities in the U.S. and accelerate scientific advancements for patients with hematological malignancies, including acute myeloid leukemia."

As part of the transaction, U.S.-based Agios employees who primarily support the oncology business will join Servier Pharmaceuticals LLC, a U.S. subsidiary of Servier. The transaction includes the transfer to Servier of Agios Pharmaceuticals’ oncology portfolio, development pipeline and research programs, notably:

TIBSOVO (ivosidenib)*.
IDHIFA (enasidenib)[i], a medicine co-promoted with Bristol Myers Squibb in the U.S.
Vorasidenib, an investigational, brain-penetrant, dual inhibitor of mutant IDH1 and IDH2 which is currently being studied in the registration-enabling Phase 3 INDIGO study in patients with IDH-mutant low-grade glioma.
AG-270, an investigational first-in-class methionine adenosyltransferase 2a (MAT2A) inhibitor being evaluated in combination with taxanes in patients with methylthioadenosine phosphorylase (MTAP)-deleted non-small cell lung cancer and pancreatic cancer.
Under the terms of the transaction agreement, Agios received an upfront payment of $1.8 billion from Servier and is eligible to receive an additional $200 million in a potential regulatory milestone, plus royalties. The transaction has been approved by both companies’ respective boards of directors and Agios’ shareholders. All regulatory clearances have been received from government authorities outlined in the agreement.

[i]Please see the full prescribing information for IDHIFA (enasidenib) and TIBSOVO (ivosidenib), including the Boxed WARNINGS.

On April 1, 2021 F-star Therapeutics, Inc. (NASDAQ: FSTX), a clinical-stage biopharmaceutical company dedicated to developing next generation bispecific immunotherapies to transform the lives of patients with cancer,reported that Ares Trading S.A., an affiliate of Merck KGaA, Darmstadt, Germany has exercised its option to develop an additional bispecific program under the ongoing collaboration with F-star (Press release, F-star, APR 1, 2021, View Source [SID1234577551]).

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This is the third option to license a preclinical program that Merck KGaA, Darmstadt, Germany has exercised in the ongoing collaboration with F-star. Merck KGaA, Darmstadt, Germany and F-star originally entered into a collaboration agreement in 2019 with the first option to license. In July 2020, Merck KGaA, Darmstadt, Germany brought the second program from the collaboration into its pipeline, and today has exercised its third option, taking over future development and commercialization of the program. An undisclosed option exercise payment will be made to F-star. Merck KGaA, Darmstadt, Germany will pay future success-based milestones and royalties on any net sales, resulting from programs covered by the agreement.

Eliot Forster, CEO of F-star Therapeutics, Inc, said: "We are delighted that our ongoing partnership with Merck KGaA, Darmstadt, Germany, continues to deliver novel programs, and further demonstrates the capacity of F-star’s proprietary mAb2 antibody platform to produce scientifically and commercially attractive programs in immuno-oncology. Our ongoing collaboration with a trusted partner sits alongside the ongoing development of our four clinical stage next-generation immunotherapies."

On April 1, 2021 Aeglea BioTherapeutics, Inc. (NASDAQ:AGLE), a clinical-stage biotechnology company developing a new generation of human enzyme therapeutics to benefit people with rare metabolic diseases, reported it will participate in two virtual investor conferences in April 2021 (Press release, Aeglea BioTherapeutics, APR 1, 2021, View Source [SID1234577543]).

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Conference Details

Conference Name: 2021 Virtual Wells Fargo Biotech Corporate Access Day
Conference Date: Tuesday, April 6 and Thursday, April 8
Participants: Anthony G. Quinn, M.B. Ch.B., Ph.D., Aeglea’s president and chief executive officer and Michael C. Hanley, Aeglea’s chief commercial officer

Conference Name: 20th Annual Needham Virtual Healthcare Conference
Conference Date: Monday, April 12 through Thursday, April 15
Presentation Date and Time: Tuesday, April 13 at 11:00 am ET
Presenter: Anthony G. Quinn, M.B. Ch.B., Ph.D., Aeglea’s president and chief executive officer
Webcast: View Source

To access the live and archived webcast, visit the Events & Presentations section of the Company’s website. Please connect to the website at least 15 minutes prior to the presentation to allow for any software download that may be necessary. A replay of the webcast will be available through the Company’s website for 30 days thereafter.

On April 1, 2021 Autolus Therapeutics plc (Nasdaq: AUTL), a clinical-stage biopharmaceutical company developing next-generation programmed T cell therapies, reported that management will participate in 1×1’s at investor conferences through April 2021 (Press release, Autolus, APR 1, 2021, View Source [SID1234577542]).

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April 6 and 8, 2021 – Wells Fargo Annual Biotech Corporate Access
April 14, 2021 – 20th Annual Needham Virtual Healthcare Conference – As well as 1×1’s, the CEO and CFO will participate in a Fireside Chat at 10:15 AM ET. A webcast of the Fireside Chat will be available on the investor relations section of the Company’s website at Autolus.
April 22, 2021 – Raymond James Oncology Summit
April 28, 2021 – Kempen & Co. European Life Sciences: Gene, Cell, and RNA Day