On January 14, 2021 Integra LifeSciences Holdings Corporation (NASDAQ: IART), a leading global medical technology company, reported certain unaudited preliminary fourth quarter and full-year 2020 revenue results (Press release, Integra LifeSciences, JAN 14, 2021, View Source [SID1234574003]).

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Preliminary Fourth Quarter and Full-Year 2020 Revenue Results

Fourth quarter 2020 revenue is expected to be in a range of $387 to $389 million, representing a decrease of 2.1% to 1.6% on a reported basis and a decrease of 1.9% to 1.4% on an organic basis compared to the prior year.

Based on these results, revenue will be above the midpoint of the fourth quarter outlook range the Company provided in October and represents a sequential revenue improvement from the third quarter.

As a result of its fourth quarter preliminary results, the Company expects full-year 2020 reported revenue to be in a range of $1,370 million to $1,372 million, representing a decrease of 9.7% to 9.6% on a reported basis and a decrease of 8.8% to 8.7% on an organic basis.

The preliminary results set forth above are unaudited and remain subject to completion of the Company’s financial closing procedures.

"We are pleased with our execution and performance during the fourth quarter, despite the challenges brought on by the pandemic," said Peter Arduini, Integra’s president and chief executive officer. "For 2021, we believe the continued recovery of our business, combined with the changes to our portfolio resulting from the divestiture of Extremity Orthopedics and the acquisition of ACell, position the company for growth."

As a reminder, on January 4, 2021, the Company completed the divestiture of its Extremity Orthopedics business. Also, on December 16, 2020, the Company announced it had entered into a definitive agreement to acquire ACell, Inc. ("ACell"). The Company continues to expect this transaction to close in the first quarter of 2021, subject to the satisfaction of customary conditions, including regulatory approvals.

The Company is scheduled to present at the 39th Annual J.P. Morgan Healthcare Conference on Thursday, January 14, 2021 at 8:20am ET. A live audio webcast of the presentation will be available on the Investor section of the company’s website at www.integralife.com

Fourth Quarter and Full-Year 2020 Financial Results Conference Call

The Company will release fourth quarter and full-year 2020 financial results on Thursday, February 18, 2021 before the market opens. In conjunction with the earnings release, Integra’s management team will host a conference call at 8:30 a.m. ET.

As part of this call the Company will provide an update on first quarter and full-year 2021 expectations.

The live call is accessible by dialing (888) 394-8218 and using the passcode 5905980. A simultaneous webcast of the call will be available via the Company’s website at www.integralife.com.

A webcast replay of the call can be accessed through the Investor Relations homepage of Integra’s website at www.integralife.com. A replay of the call will be available until February 28, 2021 by dialing (888) 203-1112 and using the passcode 5905980.

On January 14, 2021 Bio-Techne Corporation (NASDAQ: TECH) reported that management will host a conference call and webcast on Tuesday, February 2, 2021, at 8:00 a.m. CST to review second quarter 2021 financial results (Press release, Bio-Techne, JAN 14, 2021, https://investors.bio-techne.com/news/detail/225/bio-techne-to-host-conference-call-on-february-2-2021-to-announce-second-quarter-2021-financial-results [SID1234573999]).

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Access to the discussion may be obtained as follows:

A recorded rebroadcast will be available for interested parties unable to participate in the live conference call by dialing 1-844-512-2921 or 1-412-317-6671 (for international callers) and referencing Conference ID 13715028.

The replay will be available from 11:00 a.m. CST on Tuesday, February 2, 2021 until 11:00 p.m. CST on Tuesday, March 2, 2021.

On January 14, 2021 Hutchison China MediTech Limited ("Chi-Med") (Nasdaq/AIM: HCM) reported that the final analysis of savolitinib in Phase Ib TATTON study Parts B and D will be presented at the upcoming virtual 2020 World Conference on Lung Cancer (WCLC 2020), taking place on January 28-31, 2021, virtually (Press release, Hutchison China MediTech, JAN 14, 2021, https://www.chi-med.com/chi-med-highlights-savolitinib-clinical-data-to-be-presented-at-virtual-wclc/ [SID1234573998]).

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Further details of the featured poster presentation are as follows:

Title: Osimertinib + savolitinib in patients with EGFRm MET-amplified/overexpressed NSCLC: Phase Ib TATTON Parts B and D final analysis
Lead Author: Ji-Youn Han, Center for Lung Cancer, National Cancer Center, Goyang, Republic of Korea
Session: FP14 – Targeted Therapy – Clinically Focused
Abstract # / Link: #FP14.03 / Link
Availability Date: Thursday, January 28, 2021 (from midnight Singapore time)

About Savolitinib
Savolitinib is an oral, potent, and highly selective small molecule inhibitor of MET, a receptor tyrosine kinase which has been shown to function abnormally in many types of solid tumors promoting tumor growth, angiogenesis, and metastasis. Savolitinib has been studied in over 1,000 patients to date. In clinical studies, it has shown promising clinical efficacy in patients with MET gene alterations in multiple tumor types with an acceptable safety profile.

In 2011, Chi-Med entered into a global licensing and joint development and commercialization agreement with AstraZeneca PLC (LSE/STO/NYSE: AZN) for savolitinib. Savolitinib’s global development plan includes non-small cell lung cancer ("NSCLC") and kidney cancer, and additional MET-driven tumors are being explored.

Savolitinib development in NSCLC:
Phase II in MET Exon 14 alteration NSCLC (NCT02897479) – In May 2020, data from an ongoing open-label, Phase II registration study was presented as part of the American Society of Clinical Oncology (ASCO) (Free ASCO Whitepaper) 2020 Virtual Scientific Program ("ASCO 2020"). In patients with MET Exon 14 skipping alteration NSCLC in the efficacy evaluable population, savolitinib demonstrated a 49.2% objective response rate ("ORR"), a 93.4% disease control rate (DCR) and a 9.6 months interim duration of response ("DoR"). 36% of patients in the study have pulmonary sarcomatoid carcinoma (PSC), an aggressive subtype of NSCLC. Data were not yet mature for DoR, progression-free survival (PFS) or overall survival ("OS"). Clinical data indicated an acceptable safety profile, with a low adverse event (AE) related discontinuations rate of 14.3%. This data supported the China new drug application ("NDA") acceptance in May 2020.

SAVANNAH Phase II study of savolitinib in combination with Tagrisso in patients who have progressed following Tagrisso due to MET amplification or overexpression (NCT03778229) – The SAVANNAH study is a single-arm, open-label study in epidermal growth factor receptor ("EGFR") mutation positive NSCLC patients with MET amplified/overexpressed tumors following progression after treatment with Tagrisso, an EGFR-tyrosine kinase inhibitor owned by AstraZeneca.

Savolitinib development in kidney cancer:
MET-driven papillary renal cell carcinoma ("RCC") (NCT03091192) – In May 2020, data from 60 patients in the SAVOIR global study of savolitinib monotherapy compared with sunitinib monotherapy in MET-driven papillary RCC was presented at ASCO (Free ASCO Whitepaper) 2020. Savolitinib demonstrated encouraging activity, including an ORR of 27% versus 7% for sunitinib, with no savolitinib responding patients with disease progression at data cut-off, and an encouraging OS hazard ratio of 0.51 (95% CI: 0.21–1.17; p=0.110) with median not reached at data cut-off.

CALYPSO Phase II of savolitinib in combination with Imfinzi PD-L1 inhibitor in RCC (NCT02819596) – The CALYPSO study is an investigator initiated open-label Phase I/II study of savolitinib in combination with Imfinzi, a PD-L1 antibody owned by AstraZeneca. The study is evaluating the safety and efficacy of the savolitinib/Imfinzi combination in patients with papillary RCC and clear cell RCC.

Based on these data, AstraZeneca and Chi-Med are actively evaluating the opportunity to progress clinical work in papillary RCC for savolitinib.

Savolitinib development in other cancer indications:
Savolitinib opportunities are also continuing to be explored in multiple other MET-driven tumor settings via investigator-initiated studies including gastric cancer and colorectal cancer.

On January 14, 2021 Ichnos Sciences Inc., a fully integrated, global biotechnology company developing potentially transformative biologic therapies that harness the immune system to treat cancer, reported that Alessandro Riva, M.D., Chief Executive Officer, will be presenting today at the virtual 39th Annual J.P. Morgan Healthcare Conference at 3:45 p.m. EST (Press release, Ichnos Sciences, JAN 14, 2021, View Source [SID1234573997]).

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A live audio direct link to the virtual session, along with the slide deck, will be available at the following location. An archived replay of the presentation will be available for 30 days following the event. These links will also be available on the Ichnos Sciences website.

On January 14, 2021 Xenetic Biosciences, Inc. (NASDAQ:XBIO) ("Xenetic" or the "Company"), a biopharmaceutical company focused on advancing XCART, a personalized CAR T platform technology engineered to target patient- and tumor-specific neoantigens, reported that Jeffrey Eisenberg, Chief Executive Officer of Xenetic will present at NobleCon17 – Noble Capital Markets’ Seventeenth Annual Investor Conference on Tuesday, January 19, 2021 at 9:45 AM ET (Press release, Xenetic Biosciences, JAN 14, 2021, View Source [SID1234573996]).

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A high-definition, video webcast will be available at the time of the Company’s presentation to those registered to attend the event. The conference is virtual, with no cost, obligation or restrictions to attend: www.noblecon17.com.

A webcast replay will be available approximately 24 hours following the presentation on the IR Calendar page of the Investors section of the Company’s website (xeneticbio.com), and as part of a complete catalog of presentations to be rebroadcast on Channelchek, www.channelchek.com, next month.