On January 20, 2021 CytomX Therapeutics, Inc. (Nasdaq:CTMX), a clinical-stage, oncology-focused biopharmaceutical company with a vision of transforming lives with safer, more effective therapies, reported the pricing of an underwritten public offering of 14,285,714 shares of its common stock at a price to the public of $7.00 per share, for gross proceeds of $100 million, before deducting underwriting discounts and commissions and estimated offering expenses payable by CytomX (Press release, CytomX Therapeutics, JAN 20, 2021, View Source [SID1234574163]). All shares are being offered by CytomX. In addition, CytomX has granted the underwriters a 30-day option to purchase up to an additional 2,142,857 shares of its common stock at the public offering price, on the same terms and conditions.

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CytomX expects to use the net proceeds from this offering to further develop its proprietary Probody therapeutics pipeline and research. In particular, CytomX expects to use the net proceeds, together with existing cash resources, to fund: (i) the advancement and expansion of the clinical development program for CX-2009, including the ongoing Phase 2 study of CX-2009 as monotherapy and in combination with CX-072 in breast cancer; (ii) the advancement and expansion of the clinical development program for CX-2029, including the ongoing Phase 2 study of CX-2029 in four types of cancer; (iii) IND enabling studies for CX-2043 and CX-904, their IND submissions and Phase 1 clinical development; and (iv) further research and development activities related to our Probody platform, the tumor microenvironment, new drug candidates and translational sciences. CytomX expects to use any remaining net proceeds from this offering for capital expenditures, working capital and other general corporate purposes.

The offering is expected to close on or about January 25, 2021, subject to satisfaction of customary closing conditions.

J.P. Morgan Securities LLC, Cowen and Company, LLC and Piper Sandler are acting as joint bookrunning managers for the offering.

The securities are being offered pursuant to a registration statement that was filed with the Securities and Exchange Commission ("SEC") on November 6, 2018, amended on February 6, 2019, and was declared effective on February 11, 2019. A preliminary prospectus supplement relating to and describing the terms of the offering was filed with the SEC on January 19, 2021 and is available on the SEC’s website at www.sec.gov. Copies of the preliminary prospectus supplement and the accompanying prospectus relating to these securities may also be obtained for free from: J.P. Morgan Securities LLC, c/o Broadridge Financial Solutions, 1155 Long Island Avenue, Edgewood, New York 11717, telephone: 1-866-803-9204, or by emailing at [email protected]; Cowen and Company, LLC, c/o Broadridge Financial Solutions, 1155 Long Island Avenue, Edgewood, NY 11717, via telephone: +1 (833) 297-2926, or via email: [email protected]; and Piper Sandler & Co., Attention: Prospectus Department, 800 Nicollet Mall, J12S03, Minneapolis, MN 55402, or by telephone at 800-747-3924, or by email at [email protected].

This press release shall not constitute an offer to sell or the solicitation of an offer to buy, nor shall there be any sale of, these securities in any state or jurisdiction in which such offer, solicitation, or sale would be unlawful prior to registration or qualification of these securities under the securities laws of any such state or jurisdiction.

On January 20, 2021 RenovoRx, an innovator in targeted cancer therapy, reported two research studies were presented at the 2021 ASCO (Free ASCO Whitepaper) Gastrointestinal Cancers Symposium that further advance the science of pancreatic cancer treatment (Press release, Renovorx, JAN 20, 2021, View Source [SID1234574161]). In one presentation, preliminary data from the ongoing Phase III TIGeR-PaC Clinical Trial was used to investigate incidence of sepsis in pancreatic cancer patients. In the second presentation, data regarding resection rates in patients with Locally Advanced Pancreatic Cancer (LAPC) undergoing IV gemcitabine + nab-paclitaxel treatment regimens as part of the induction phase of the TIGeR-PaC study was shared. The TIGeR-PaC trial’s primary goal is to determine whether its proprietary Trans-Arterial Micro-Perfusion (TAMP) procedure utilizing intra-arterial gemcitabine can reduce the chance of cancer spreading and extend survival while improving quality of life for pancreatic cancer patients.

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"The data presented at the 2021 ASCO (Free ASCO Whitepaper) Gastrointestinal Cancers Symposium indicates how the TIGeR-PaC trial is helping to advance the science for pancreatic cancer treatment beyond its primary goals," said Dr. Ramtin Agah, Chief Medical Officer and Co-Founder at RenovoRx. "One study addresses the potential of risk stratifying patients that may become septic in their standard of care systemic chemotherapy treatment protocol. The other presentation helps us better understand how the gemcitabine + nab-paclitaxel chemotherapy regimen can aid resection rates for LAPC patients."

Studies presented at 2021 ASCO (Free ASCO Whitepaper) Gastrointestinal Cancers Symposium:

"Sepsis and pancreatic cancer: Biliary stents a significant risk factor in patients undergoing chemotherapy," presented by Michael J. Pishvaian, Charles Li, et al. evaluated the occurrence of sepsis in pancreatic cancer patients with biliary stents included in the TIGeR-PaC trial. The placement of a biliary stent can be used to alleviate complications from the obstruction of the bile duct. The findings concluded that combined with the immunosuppressive qualities of chemotherapy, the likelihood of sepsis increases, with incidence rates significantly greater than those previously reported in the drugs’ prescribing information or previous studies. The current practice of the insertion of the biliary stent potentially introduces bacteria during the procedure, resulting in potential infection later with administration of chemotherapy.

"Resection rate of locally advanced pancreatic cancer in gemcitabine plus nab-paclitaxel versus FOLFIRINOX," presented by Michael J. Pishvaian, Shahriar Sharif, et al. evaluated the resection rate in LAPC patients using regimens approved for metastatic pancreatic cancer. There currently is no established treatment for LAPC and because of the complexity of surgically removing the tumor in this population, hope remains for rendering them to the point of resectablity with chemotherapy. This study compared the common systemic treatment regimens used in LAPC including intravenous gemcitabine plus nab-paclitaxel (Gem-Nab) chemotherapy and FOLFIRINOX (a combination of five chemotherapy agents). To evaluate the Gem-Nab treatment approach, the research team used data from the TIGeR-PaC clinical trial’s induction phase and control arm of the study. The study concluded that in the younger cohort of patients, TIGeR-PaC results are in line with the data of 15% resection rate from another trial of patients with median age of 65 years. In the TIGeR-PaC study the resection rate for LAPC treated with systemic Gem-Nab chemotherapy was 10% overall, and 18.2% for the younger patient population. These resection rates are comparable to the other reports for Gem-Nab and are similar to retrospective reports for the younger patients undergoing resection after treatment with FOLFIRINOX.

The TIGeR-PaC study, which currently has approximately 30 active clinical sites, is ultimately expected to involve approximately 200 participants in the US and Europe. To learn more, visit View Source

On January 20, 2021 Lantern Pharma (Nasdaq: LTRN), a clinical-stage biopharma company using its proprietary RADR artificial intelligence ("A.I.") platform to transform cancer drug development and identify patients who will benefit from its targeted oncology therapeutics, reported the closing of its previously announced public offering of 4,928,571 shares of its common stock at a public offering price of $14.00 per share, which includes 642,856 shares sold upon full exercise of the underwriter’s option to purchase additional common shares (Press release, Lantern Pharma, JAN 20, 2021, View Source [SID1234574160]). The gross proceeds from the offering, including the exercise of the over-allotment option, were $68,999,994, before deducting underwriting discounts, commissions and offering expenses.

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ThinkEquity, a division of Fordham Financial Management, Inc., acted as sole book-running manager for the offering. Colliers Securities LLC acted as co-manager for the offering.

A registration statement on Form S-1 (File No. 333-251992) relating to the shares was filed with the Securities and Exchange Commission and became effective on January 14, 2021, and a related registration statement on Form S-1 (File No. 333-252116) was filed pursuant to Rule 462(b) of the Securities Act of 1933, as amended, in connection with the upsizing of the offering. This offering was made only by means of a prospectus. Copies of the final prospectus may be obtained from ThinkEquity, a division of Fordham Financial Management, Inc., 17 State Street, 22nd Floor, New York, New York 10004, by telephone at (877) 436-3673, by email at [email protected].

This press release shall not constitute an offer to sell or a solicitation of an offer to buy these securities, nor shall there be any sale of these securities in any state or other jurisdiction in which such offer, solicitation or sale would be unlawful prior to the registration or qualification under the securities laws of any such state or other jurisdiction.

On January 20, 2021 TRIGR Therapeutics, Inc. ("TRIGR"), a US based clinical stage biopharmaceutical company focused on the development of multi-targeted angiogenic and immunomodulatory bispecific antibodies for oncology and certain ischemic indications and Elpiscience Biopharmaceuticals, a leading China based clinical stage company focused on developing next generation of cancer immunotherapies reported that they have entered into an exclusive licensing agreement for the development and commercialization of TR009 in mainland China, Hong Kong, Macau and Taiwan (Press release, TRIGR Therapeutics, JAN 20, 2021, View Source [SID1234574159]).

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Under the terms of the agreement, TRIGR will receive an upfront cash payment of $7 million and is eligible to receive additional development and commercial milestones of $110 million plus royalties on annual net sales of TR009. Elpiscience obtains the exclusive development and commercialization rights of TR009 for Greater China across all oncology indications and will lead the clinical development and commercialization by leveraging on its translational science, clinical and regulatory experience to accelerate the path to approval of TR009 in its territory. A Joint Development Committee (JDC) will be formed to collaborate and harmonize TR009’s clinical development globally.

George Uy, Founder and Chief Executive Officer of TRIGR stated, "TRIGR was formed with a vision to globalize drug development and accelerate transformative treatment to patients worldwide. Our partnership with Elpiscience in Greater China is a significant milestone in this endeavor. We would also like to acknowledge and thank ABL Bio (KOSDAQ: 298380), the originator of TR009 (aka ABL001/NOV1501) for their support in the Phase 1 clinical studies and immense contribution to this program, along with HANDOK (KOSDAQ:002390), National Oncoventure (NOV) and Binex (KOSDAQ:053030)."

Dr. Darren Ji, co-Founder, Chairman and Chief Executive Officer of Elpiscience stated, "Elpiscience is committed to delivering the next generation of cancer immunotherapy to patients who cannot benefit from current treatment. TR009 has demonstrated impressive single agent activity in tumor types that are poorly responsive to present immunotherapies and is highly synergistic with our next generation immune modulators. The addition of TR009 to our pipeline will further strengthen our efforts in tackling "cold tumors" and delivering efficient therapeutics."

Miranda Toledano, Chief Operating/ Financial Officer of TRIGR stated "Emerging data from our Phase 1 studies demonstrate TR009 is a highly differentiated dual angiogenic blocker, safely inhibiting both DLL4-mediated Notch signaling and VEGF with activity across several DLL4 overexpressed tumors. We believe this profile could position TR009 as a next generation angiogenic flagship molecule with multiple rational combinations and sBLA opportunities." Dr. Steve Chin, Chief Medical Officer of Elpiscience added, "We were particularly encouraged by TR009 data in heavily pre-treated tumors refractory to anti-VEGF such as colorectal and gastric cancers. We look forward to working together with the TRIGR team to expedite delivery to patients."

About TR009

TR009 (aka ABL001/NOV1501) is an anti-VEGFxDLL4 bispecific antibody, which is composed of an anti-VEGF antibody backbone C-terminally linked with a proprietary DLL4-targeting single-chain variable fragment. Data from TR009’s ongoing Phase 1 Dose Escalation/Expansion Monotherapy and Phase 1B Combination studies (n~60 patients) demonstrate a 67% Clinical Benefit Rate, with deep and sustained partial responses per RECIST criteria in heavily pre-treated colorectal and gastric cancer patients that have failed at least 3 lines of prior therapy and become resistant to multi-VEGF (Avastin, Stivarga, Cyramza), EGFR, anti-PD-1/PD-L1 and chemotherapies. The Phase 1B results testing the safety of TR009 in combination with irinotecan or paclitaxel, have also shown deep and sustained partial responses in difficult to treat 3rd / 4th line Intrahepatic Cholangiocarcinoma (Biliary Tract Cancer) and Non-Small Cell cancer patients that have failed multiple lines of chemo, biological therapy, and anti-PD-1. TR009 has been safety administered up to 17.5mg/kg dose with no dose limiting toxicities (DLT). In contrast to historical DLL4 and other Notch targeted therapies, the administration of TR009 has not been hampered by pulmonary hypertension or other cardiac toxicities. Further updates on these studies will be provided later in 2021.

On January 20, 2021 BioInvent International AB ("BioInvent") (OMXS: BINV), a biotech company focused on the discovery and development of novel and first-in-class immune-modulatory antibodies for cancer immunotherapy reported that it will host a Key Opinion Leader call on BI-1206 for relapsed or refractory Non-Hodgkin’s Lymphoma on Thursday, January 28, 2021 at 11:30 a.m. Eastern Time (5:30 p.m. CET) (Press release, BioInvent, JAN 20, 2021, View Source [SID1234574158]).

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The event will feature a presentation by renowned lymphoma expert Mats Jerkeman, MD, Lund University, who will discuss the current treatment landscape, and unmet medical need for patients with relapsed or refractory Non-Hodgkin’s Lymphoma for whom current treatment options are very limited. Dr Jerkeman will also discuss his experience in treating these patients with BioInvent’s anti-FcγRIIB antibody, BI-1206, a novel monoclonal antibody that specifically targets the antibody "brakes" to help overcome resistance to rituximab.

BioInvent’s management team will also give an update on the ongoing Phase I/IIa trial of BI-1206 in combination with rituximab and BioInvent’s partner CASI Pharmaceuticals (NASDAQ: CASI) will provide an update on the development plan and potential for BI-1206 in China. Dr. Jerkeman and senior members of the BioInvent and CASI management teams will be available to answer questions following the formal presentations.

To register for the call, please click here.

Dr. Mats Jerkeman is Professor in Clinical Oncology at Lund University, Sweden. His research focus is all possible aspects of malignant lymphomas, aiming for the improvement of the quality of life and survival of these patients.

Dr. Jerkeman is the coordinator of several ongoing clinical trials in diffuse large B-cell lymphoma and mantle cell lymphoma. He also serves as Chairman of the Nordic Lymphoma Group, Editor of ESMO (Free ESMO Whitepaper) Guidelines/Lymphoma and as coordinator of the Swedish Lymphoma Register for many years.