Phio Pharmaceuticals Announces $14.0 Million Private Placement Priced At-the-Market

On January 21, 2021 Phio Pharmaceuticals Corp. (Nasdaq: PHIO), a biotechnology company developing the next generation of immuno-oncology therapeutics based on its proprietary self-delivering RNAi (INTASYL) therapeutic platform, reported that it has entered into securities purchase agreements with certain institutional and accredited investors to raise approximately $14.0 million through the issuance of an aggregate of 4,560,928 shares of its common stock (or common stock equivalents in lieu thereof) and warrants to purchase up to an aggregate of 3,420,693 shares of common stock, at a purchase price of $3.07 per share of common stock (or common stock equivalent in lieu thereof) and associated warrant in a private placement priced at-the-market under Nasdaq rules (Press release, Phio Pharmaceuticals, JAN 21, 2021, View Source [SID1234574173]). The closing of the private placement is expected to occur on or about January 25, 2021, subject to the satisfaction of customary closing conditions.

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H.C. Wainwright & Co. is acting as the exclusive placement agent for the offering.

The warrants have an exercise price of $3.00 per share, are exercisable immediately and have a term of five and one-half years.

The Company currently intends to use the net proceeds from the offering for the development of its immuno-oncology programs, other research and development activities and for general working capital needs.

The offer and sale of the foregoing securities are being made in a transaction not involving a public offering and have not been registered under the Securities Act of 1933, as amended (the "Securities Act"), or applicable state securities laws. Accordingly, the securities may not be reoffered or resold in the United States except pursuant to an effective registration statement or an applicable exemption from the registration requirements of the Securities Act and such applicable state securities laws.

Under an agreement with the investors, the Company is required to file an initial registration statement with the Securities and Exchange Commission covering the resale of the shares of common stock to be issued to the investors within ten calendar days and to use its best efforts to have the registration statement declared effective as promptly as practical thereafter, and in any event no later than 90 days after today in the event of a "full review" by the Securities and Exchange Commission.

This press release does not constitute an offer to sell or the solicitation of an offer to buy any securities, nor shall there be any sale of the securities in any state in which such offer, solicitation or sale would be unlawful prior to the registration or qualification under the securities laws of such state.

Pascal Biosciences to Present at Cannabinoid Derived Pharmaceuticals Industry Review Summit

On January 21, 2021 Pascal Biosciences, Inc. ("Pascal" or the "Company") (TSXV: PAS) (OTC:BIMUF), reported that it will present at the first Cannabinoid Derived Pharmaceuticals Industry Review Summit today (Press release, Pascal Biosciences, JAN 21, 2021, View Source [SID1234574171]). Dr. Patrick Gray, CEO of Pascal Biosciences, will present advancements of Pascal’s development program for treatment of glioblastoma with PAS-403. The title of his presentation is "Discovery & Development of a Cannabinoid-Derived Therapeutic for Glioblastoma".

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The Cannabinoid Derived Pharmaceuticals Industry Review Summit is the first European conference aimed to address challenges in the clinical development and commercialization of cannabinoids and drugs derived from cannabinoids. Based in London, this virtual conference is the premier format for presentation of ground-breaking discoveries in cannabinoid drug development. This meeting is hosting pharmaceutical experts developing therapeutics derived from cannabis. In addition to describing progress for Pascal’s program in glioblastoma, Dr. Gray will also discuss plans for developing PAS-393 for treatment of cancer in combination with checkpoint inhibitors. This collaborative effort with SōRSE Technology aims to characterize the safety, pharmacology, and pharmacokinetics of PAS-393 in a Phase 1a clinical trial.

"I am very pleased for the invitation to present Pascal’s work at this impressive conference," commented Dr. Gray. "This validates the importance of our efforts, and we will be featured with other companies making significant advancements in developing cannabis-based medicines." The session featuring Pascal’s presentation is titled "Linking Cannabinoids to their Therapeutic Potential".

CORMEDIX INC. TO BEGIN TRADING ON THE NASDAQ STOCK EXCHANGE

On January 21, 2021 CorMedix Inc. (NYSE American: CRMD), a biopharmaceutical company focused on developing and commercializing therapeutic products for the prevention and treatment of infectious and inflammatory disease, reported that it has been approved for listing on the Nasdaq Global Market (Press release, CorMedix, JAN 21, 2021, View Source [SID1234574170]). The company’s shares will continue to trade under its current symbol "CRMD". Trading on the Nasdaq Global Market is expected to commence on Tuesday, February 2, 2021. The Company’s shares of common stock will continue to trade on the NYSE American until the close of the market on Monday, February 1, 2021.

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Khoso Baluch, CorMedix CEO commented, "We are excited to have Nasdaq as our new exchange partner. As a late stage biopharma company, we feel that Nasdaq is a natural fit and already includes many of our peers in the space. With the February 28, 2021 PDUFA date for completion of FDA’s review of the Defencath NDA on the horizon, the year ahead is likely to hold significant growth for CorMedix as we set our sights on becoming a commercial entity in the US. We believe this move will further enhance our visibility in the marketplace, expose our company to a larger audience of institutional investors and ultimately increase liquidity and shareholder value."

Genprex to Present its Cutting-Edge Gene Therapies at the MoneyShow Accredited Investors Virtual Expo

On January 21, 2021 Genprex, Inc. ("Genprex" or the "Company") (NASDAQ: GNPX), a clinical-stage gene therapy company focused on developing life-changing therapies for patients with cancer and diabetes, reported that the Company will present at the MoneyShow Accredited Investors Virtual Expo taking place virtually January 26-28, 2021 (Press release, Genprex, JAN 21, 2021, View Source [SID1234574169]). Genprex’s President and Chief Executive Officer, Rodney Varner, will virtually deliver a company overview, including recent progress made on its upcoming clinical trials, to participating investors on Thursday, January 28.

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Event: MoneyShow Accredited Investors Virtual Expo

Presentation Date: Thursday, January 28

Presentation Time: 12:25 p.m. EST

Registration Link: http://bit.ly/3p0yJOl

The presentation will be available for replay on the Company’s website (www.genprex.com) for a period of time following the conference, and the video will be archived on MoneyShow.com.

Prescient Therapeutics chooses three cancer programs for its next-generation CAR T platform

On January 21, 2021 Prescient Therapeutics (ASX:PTX) reported that what’s next for its next-generation gene therapy technology for fighting cancer (Press release, Prescient Therapeutics, JAN 21, 2021, View Source;utm_medium=rss&utm_campaign=prescient-therapeutics-chooses-three-cancer-programs-for-its-next-generation-car-t-platform [SID1234574167]).

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Melbourne-based Prescient will focus development of its OmniCAR platform into three programs: the blood cancer acute myeloid leukemia (AML); solid tumours including breast, ovarian and gastric cancers; and glioblastoma multiforme, the aggressive brain cancer.

Prescient’s OmniCAR technology represents a step up from the current chimeric antigen receptor T-cell (CAR T) therapy, a form of immunotherapy that involves modifying a patient’s white blood cells so they recognise and kill cancer cells.

An American woman, Laurie Adami, recently told Stockhead how CAR T therapy saved her life by curing her stage IV follicular non-Hodgkin lymphoma.

Prescient says its OmniCAR tech is expected to be safer and more effective than the current generation of CAR T treatments, which are only a few years old.

CAR T cells using OmniCAR will be able to target multiple cancer antigens simultaneously, and the platform offers "persistent dosing and tumour microenvironment enhancements to improve efficacy," Prescient says.

While OmniCAR has a range of applications, the company decided to narrow its focus to the three cancer programs after a strategic review that took into account all the known CAR T programs in development worldwide.

The company said it tried to strike a balance between the probability of technical success and being able to bring to market a differentiated, commercially viable treatment. Prescient didn’t want to risk developing a "me too" CAR T treatment that duplicated an existing therapy.

"Each of the programs represent a tremendous market opportunity," says Prescient chief executive Steven Yatomi-Clarke.

"Furthermore, Prescient will continue to seek collaboration with external parties on additional opportunities where OmniCAR can create additional next-generation CAR therapies with partners."

Prescient licensed OmniCAR from the University of Pennsylvania, a leader in CAR T which developed Kymriah, a Novartis therapy approved as a treatment for B-cell acute lymphoblastic leukemia (ALL).

Prescient says the vigorous development program will move OmniCAR towards the clinic while demonstrating the unique features of the technology in treating patients – adding tremendous value to the platform.