Artiva Biotherapeutics Announces Appointment of Dr. Fred Aslan as President and CEO

On January 5, 2021 Artiva Biotherapeutics, Inc., an oncology company focused on developing and commercializing primary allogeneic natural killer (NK) cell therapies to treat cancer, reported the appointment of Fred Aslan, M.D., as President and Chief Executive Officer (Press release, Artiva Biotherapeutics, JAN 5, 2021, View Source [SID1234573508]). Dr. Aslan brings a twenty-year track record as an executive and investor in the life sciences industry.

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"Fred is a highly accomplished leader who can help us deliver the full potential of Artiva’s platform," stated Brian Daniels, M.D., chairman of Artiva Biotherapeutics. "Fred brings strong strategic acumen from his experiences as an investor and proven operating skills building teams, scaling businesses, and orchestrating creative partnerships. We look forward to working with Fred as Artiva grows into a fully integrated oncology cell therapy company."

Prior to Artiva, Dr. Aslan was President and CBO at Vividion Therapeutics where he was responsible for business development, finance, operations, and alliance and project management. He had the opportunity to orchestrate Vividion’s Series B financing and $135M-upfront collaboration with Roche. Prior to Vividion, Dr. Aslan had a 12 year affiliation with Venrock; initially as an investor from 2006 to 2013, when he co-founded and served as a board member of Receptos Pharmaceuticals (acquired by Celgene for more than $7 billion), led Venrock’s investment in Zeltiq (acquired by Allergan for more than $2 billion), and was involved in the early formation of Fate Therapeutics; and subsequently as an entrepreneur from 2013 to 2018, when he was CEO of Adavium Medical, a Brazilian medical device company, which he grew from zero to 350 employees, increased sales to more than $40 million, and established fully integrated R&D, manufacturing, and commercial capabilities. Prior to Venrock, Dr. Aslan was Director of Business Development and Head of Investor Relations for CuraGen, a Nasdaq-listed oncology-focused biotech company. Prior to CuraGen, he was a consultant at Boston Consulting Group. Dr. Aslan currently serves as Chairman of the board of Vydence Medical and as a board member of Cytrellis Biosystems. Fred holds a B.S. in biology from Duke University, an M.D. from Yale School of Medicine, and an MBA from Harvard Business School.

"The NK cell therapy landscape is evolving rapidly – few approaches have such broad potential to generate transformational therapies against both hematologic and solid tumors, and I am excited to be joining the Artiva team as we scale our efforts," stated Dr. Aslan. "The available supporting clinical evidence of NK cell therapeutic activity, coupled with our manufacturing head-start to generate an allogeneic, off-the-shelf product thanks to the pioneering work by our strategic partner GC LabCell, positions Artiva as one of the leaders in this exciting emerging field. With our first IND now allowed and two more planned for the next 18 months, we plan to be the first company to dose cord-blood derived NK cells to patients using a highly scaled, cryopreserved, end-to-end GMP manufacturing process. We are also encouraged by the pharmaceutical industry’s growing interest in this field and our work."

Tom Farrell, founder and former CEO of Artiva, will transition to Chief Strategy Officer where he will continue to lead several strategic initiatives for the Company. "Tom has done an outstanding job recognizing the potential of GC LabCell’s pioneering work in the NK cell therapy space, establishing strong ties between the two companies, and successfully building Artiva to where it is today," stated Dr. Aslan. "I look forward to working with Tom as we further accelerate Artiva’s rapid pace of progress."

PharmaEssentia to Present at the 39th Virtual Annual J.P. Morgan Healthcare Conference

On January 5, 2021 PharmaEssentia Corporation (TPEx: 6446), a global biopharmaceutical innovator leveraging deep expertise and proven scientific principles to deliver new biologics in hematology and oncology, reported its plans to present at the 39th Annual J.P. Morgan Healthcare Conference via webcast (Press release, PharmaEssentia, JAN 5, 2021, View Source [SID1234573507]). Meredith Manning, PharmaEssentia’s U.S. General Manager, is scheduled to present on Monday, January 11, 2021 at 10:25 a.m. Eastern Time.

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Deciphera Pharmaceuticals to Present at the 39th Annual J.P. Morgan Healthcare Conference

On January 5, 2021 Deciphera Pharmaceuticals, Inc. (NASDAQ:DCPH) reported that Steve Hoerter, President and Chief Executive Officer, will present at the 39th Annual J.P. Morgan Healthcare Conference on Monday, January 11, 2021 at 9:10 AM ET (Press release, Deciphera Pharmaceuticals, JAN 5, 2021, View Source [SID1234573460]).

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A live webcast of the event will be available on the "Events and Presentations" page in the "Investors" section of the Company’s website at View Source A replay of the webcast will be archived on the Company’s website for 90 days following the presentation.

Ikena Oncology Closes $120 Million Series B Financing Led by Omega Funds

On January 5, 2021 Ikena Oncology, Inc. ("Ikena"), a clinical-stage biotechnology company that discovers and develops patient-directed, biomarker-driven cancer therapies, reported the closing of $120 million in an oversubscribed Series B financing (Press release, Ikena Oncology, JAN 5, 2021, View Source [SID1234573506]). The round was led and syndicated by Omega Funds and included participation from additional new investors: Fidelity Management & Research Company, LLC, Surveyor Capital (a Citadel company), Invus, Farallon Capital Management, BVF Partners, L.P., Cowen Healthcare Investments, Logos Capital and HealthCor Management. Existing investors Atlas Venture, OrbiMed, and Bristol Myers Squibb all participated in the round. Ikena intends to use the proceeds from this financing to advance its pipeline of targeted oncology therapies, including its novel development candidate TEAD inhibitor IK-930, and a new first-in-class preclinical program targeting KRAS signaling.

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"This exceptional group of new investors is a welcome addition to our strong existing group of shareholders as we continue to advance and build Ikena’s portfolio of targeted oncology programs for a wide range of cancer types," said Mark Manfredi, Ph.D., President and Chief Executive Officer of Ikena Oncology.

In connection with this financing, Otello Stampacchia, Ph.D., Managing Director of Omega Funds, will join Ikena’s Board of Directors.

Otello Stampacchia stated, "The rise of tumor profiling across many cancer types has rapidly increased demand for more precise and personalized treatments to improve both drug development and patient outcomes. With its portfolio of first-in-class, biomarker-driven therapies that target key cancer drivers, Ikena is uniquely positioned to have significant positive impact on cancer patients and build stakeholder value."

Jefferies LLC acted as placement agent for the financing.

TEAD Inhibitor IK-930 Enters IND-Enabling Studies

Ikena also announces that IK-930, which targets the Hippo pathway, has entered IND-enabling studies. IK-930 is a potent, selective, and orally bioavailable TEAD inhibitor that has shown favorable pharmacokinetics, pharmacodynamics, and anti-tumor activity in preclinical cancer models harboring Hippo pathway mutations. Ikena plans to file an IND in the second half of 2021 and to initiate a Phase 1 clinical trial evaluating single-agent IK-930 in biomarker-enriched patient populations, such as those with Hippo pathway-altered tumors.

New First-in-Class Preclinical Program Targeting KRAS Signaling

KRAS mutations are present in approximately 30% of all human cancers and are especially prevalent in pancreatic, lung and colorectal cancers. Ikena is pursuing a small molecule inhibitor program against an undisclosed downstream target in the KRAS signaling pathway. This target is an important mediator of tumorigenesis and metastatic progression, and a fundamental component of drug resistance in cancer. Knockout of this target prevented tumor formation in genetically engineered models of KRAS mutant lung and pancreatic cancer. Small molecule inhibition of the target blocked tumor growth in patient-derived KRAS mutated xenograft models. Currently in the lead optimization stage, Ikena expects to nominate a development candidate in the second half of 2021 and initiate IND-enabling studies.

AVEO Oncology Announces Webcast of Presentation at the 39th Annual J.P. Morgan Healthcare Conference

On January 5, 2021 AVEO Oncology (Nasdaq: AVEO) reported that Michael Bailey, president and chief executive officer of AVEO, will present at the 39th Annual J.P. Morgan Healthcare Conference on Wednesday, January 13, 2021 at 5:20 p.m. Eastern Time (Press release, AVEO, JAN 5, 2021, View Source [SID1234573505]). Following the presentation, Mr. Bailey will be joined by other members of AVEO’s management team for a question-and-answer session.

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A live webcast of the presentation and question-and-answer session can be accessed by visiting the investors section of the Company’s website at www.aveooncology.com. A replay of the webcast will be archived for 30 days following the presentation date.