On January 10, 2020 IDEXX Laboratories, Inc. (NASDAQ: IDXX), a global leader in veterinary diagnostics, veterinary practice software and water microbiology testing, has reported of its 2019 fourth quarter and full-year financial results for Friday, January 31, 2020 before the market opens (Press release, IDEXX Laboratories, JAN 10, 2020, View Source [SID1234552999]). The Company will host a conference call beginning at 8:30 a.m. ET on that day.

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Early/Late Stage Pipeline Development - Target Scouting - Clinical Biomarkers - Indication Selection & Expansion - BD&L Contacts - Conference Reports - Combinatorial Drug Settings - Companion Diagnostics - Drug Repositioning - First-in-class Analysis - Competitive Analysis - Deals & Licensing

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Individuals can access a live webcast of the conference call through a link on the IDEXX website, www.idexx.com/investors. An archived edition of the webcast will be available after 1:00 p.m. ET on that day via the same link and will remain available for one year.

The live call also will be accessible by telephone. To listen to the live conference call, please dial 1- 844-767-5679 or 1- 409-207-6967 and reference access code 176532. Replay of the conference call will be available through Friday, February 7, 2020 by dialing 1-866-207-1041 or 1- 402-970-0847 and referencing access code 8036553.

On January 10, 2020 Paradigm Diagnostics, Inc. reported that Palmetto GBA, the Medicare Administrative Contractor (MAC) for the Molecular Diagnostics MolDX program, has reviewed the technical dossier and broadly approved the Paradigm Cancer Diagnostic (PCDx) assay under the Local Coverage Determination for next-generation sequencing for solid tumors (Press release, Paradigm Diagnostics, JAN 10, 2020, View Source [SID1234552998]).

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Early/Late Stage Pipeline Development - Target Scouting - Clinical Biomarkers - Indication Selection & Expansion - BD&L Contacts - Conference Reports - Combinatorial Drug Settings - Companion Diagnostics - Drug Repositioning - First-in-class Analysis - Competitive Analysis - Deals & Licensing

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The PCDx test provides physicians and their patients with a blueprint of the underlying mechanisms of a patient’s disease, potential treatment approaches, and inventory of relevant clinical trials. The test gets results back to physicians in three to five business days, rather than weeks. The PCDx assay detects substitutions, insertion and deletion alterations (indels), and copy number alterations in 234 genes and select gene rearrangements. PCDx also detects genomic signatures, including micro satellite instability (MSI) and tumor mutational burden (TMB) using DNA isolated from formalin-fixed paraffin embedded (FFPE) tumor tissue specimens in addition to select immunohistochemistry tests.

"After an extensive technical review, the expanded Medicare coverage significantly enhances Paradigm’s ability to enable broader and earlier access to biomarker-driven treatments that may improve survival for cancer patients," said David Mallery, CEO.

On January 10, 2020 ReadCoor, Inc., a company reinventing omics and pathology with its 3-dimensional (3D) multi-omic spatial sequencing platform, reported a $27 million Series B financing to accelerate the commercialization of its proprietary FISSEQ technology for use in research, drug discovery, and diagnostics (Press release, ReadCoor, JAN 10, 2020, View Source [SID1234552997]). The Series B financing includes new investor Pavilion Capital and other investors, as well as existing investors Decheng Capital and Hansjörg Wyss.

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Early/Late Stage Pipeline Development - Target Scouting - Clinical Biomarkers - Indication Selection & Expansion - BD&L Contacts - Conference Reports - Combinatorial Drug Settings - Companion Diagnostics - Drug Repositioning - First-in-class Analysis - Competitive Analysis - Deals & Licensing

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"ReadCoor has made rapid progress in bringing multi-omic spatial sequencing from development to the market," said Victor E. Tong, Jr., Partner at Decheng Capital and Chairman of the ReadCoor board of directors. "The platform that ReadCoor has developed features a leading-edge technology to sequence and characterize tissue in 3D that offers the potential for new insights in clinical research and drug discovery."

Proceeds from the Series B financing will be used to accelerate commercialization of ReadCoor’s platform, powered by its proprietary FISSEQ (fluorescent in situ sequencing) technology, which simultaneously reads the sequences of thousands of molecules and visualizes high resolution 3D spatial information within whole cells and tissues. With first-of-a-kind capabilities to sequence and characterize data in three dimensions, ReadCoor’s platform gives researchers access to previously undiscovered data to guide evaluation and validation of new drug targets, pathogen identification, disease diagnosis, and the advancement of regenerative medicine. The platform is comprised of an instrument, kits, and data analysis and visualization cloudware, so that it can be incorporated into the workflow of researchers in research and drug discovery.

ReadCoor’s platform and product portfolio have been validated across a range of applications over the past year, including non-small cell lung cancer, breast cancer, and a brain atlas. The company’s initial product suite includes research and discovery applications in oncology, infectious disease, and neuroscience. The Select Release Program and platform will be unveiled at the 20th Advances in Genome Biology and Technology (AGBT) in February 2020.

"The development true spatial sequencing is currently burdened by technical challenges, including the need for specialized imaging hardware, laborious protocols, and unsupported analysis software. To overcome these challenges and integrate these methods, we created an all-in-one solution with unparalleled capacity for true multi-omic spatial sequencing with high-resolution 3D imaging, robust data collection and analysis," said Richard Terry, Founder, President, and Chief Executive Officer of ReadCoor. "It is gratifying that our investors support our technology and approach as we move rapidly towards commercialization, and we are excited to expand the availability of our platform to customers."

Leading up to this Series B financing, ReadCoor’s progress has been marked by collaborative agreements and research grants with leading research institutions, including the Chan Zuckerberg Initiative, Bill & Melinda Gates Foundation, Oregon Health State University, and Harvard University.

About Fluorescent in situ Sequencing (FISSEQ)
ReadCoor’s platform is powered by proprietary Fluorescent in situ Sequencing (FISSEQ) technology, which offers researchers the ability to sequence across multiple omic formats (genomics, transcriptomics, proteomics, and metabolomics) without disruption to cell structure or loss of spatial data. This platform delivers the precise locations of molecular targets and a corresponding 3D image plotting the coordinates within the sequenced sample. Currently, available sequencing technologies can only provide sequencing information, not true spatial information. FISSEQ provides both, representing the first true merging of imaging and sequencing. This 3D molecular atlas can enable meaningful scientific insights into therapeutic areas, including cancer, immuno-oncology, gene therapy, and neurodegenerative diseases, enabling researchers to gain more robust diagnostic insights to deliver precise therapeutics to patients. FISSEQ was developed in the Church Lab at Harvard University and the Wyss Institute for Biologically Inspired Engineering, and first published in Science in 2014 (Highly multiplexed three-dimensional subcellular transcriptome sequencing in situ). The platform has broad applications in the areas of drug development, diagnostics, and machine learning.

On January 10, 2020 Kronos Bio, Inc., dedicated to the development of first-in-class therapies that modulate historically undruggable targets, reported that Norbert Bischofberger, Ph.D., President and Chief Executive Officer, will present at the 38th Annual J.P. Morgan Healthcare Conference on Monday, January 13, 2020 at 10:30 a.m. Pacific Time (Press release, Kronos Bio, JAN 10, 2020, View Source [SID1234552996]). The event will be held in San Francisco at the Westin St. Francis.

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Early/Late Stage Pipeline Development - Target Scouting - Clinical Biomarkers - Indication Selection & Expansion - BD&L Contacts - Conference Reports - Combinatorial Drug Settings - Companion Diagnostics - Drug Repositioning - First-in-class Analysis - Competitive Analysis - Deals & Licensing

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Launched in May 2018, the company announced a $105 million Series A financing in July 2019 to support the advancement of its Small Molecule Microarray platform (SMM). SMM is ideally suited for the rapid discovery of novel modulators or degraders of historically undruggable targets, such as transcription factors. Kronos has demonstrated SMM’s potential to identify compounds that bind to target proteins directly or interfere at nanomolar potency with protein activity. SMM enables discovery of hits that act through a variety of mechanisms, including disruption of protein-protein or protein-DNA interactions, or indirect modulation of target protein activity by binding to co-factors or other protein complex members.

On January 10, 2020 Quanterix Corporation (NASDAQ: QTRX), a company digitizing biomarker analysis to advance the science of precision health, reported that its President, Chairman and Chief Executive Officer, Kevin Hrusovsky, will be presenting on the company’s growth and vision for the fourth consecutive year at the 38th Annual J.P. Morgan Healthcare Conference in San Francisco (Press release, Quanterix, JAN 10, 2020, View Source [SID1234552995]). Hrusovsky’s session will take place on Wednesday, Jan. 15, 2020 at 4 p.m., PST (7 p.m., EST) in California East, Westin St. Francis, with a Q&A session directly following at 4:30 p.m., PST (7:30 p.m., EST) in the Yorkshire Room, Westin St. Francis.

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Discover why more than 1,500 members use 1stOncology™ to excel in:

Early/Late Stage Pipeline Development - Target Scouting - Clinical Biomarkers - Indication Selection & Expansion - BD&L Contacts - Conference Reports - Combinatorial Drug Settings - Companion Diagnostics - Drug Repositioning - First-in-class Analysis - Competitive Analysis - Deals & Licensing

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In the two years since the Company’s very successful initial public offering, Quanterix has continued to achieve accelerated double-digit, year-over-year growth in each full quarter. The Company has had several critical milestones and achievements, including strategic acquisitions and agreements, multiple product launches that build on the renowned Simoa technology platform, new additions to its leadership team, raised nearly $120 million in 2019, continued growing in scientific publications and expanded the biomarker menu.

"Our team is relentless in its drive to change how researchers and pharmaceutical companies approach drug development and early disease detection using biomarkers," said Hrusovsky. "Our customers and collaborators have made strong strides across neurology, with a groundswell of groundbreaking research validating neurofilament light (Nf-L) as a blood-based biomarker for measuring neurodegeneration. Oncology is witnessing a similar opportunity with Simoa. We are excited to discuss the unprecedented opportunity we have before us in the research markets and ultimately clinical diagnostic markets."

Significant 2019 Achievements:

Launched the Simoa HD-X Analyzer, which delivers improved flexibility and sensitivity across a broad assay menu to empower more efficient and accurate biomarker analysis. Built upon the Company’s flagship Simoa HD-1 platform, HD-X shipments began one quarter ahead of schedule following a successful Early Access Program. Customer feedback on the HD-X has been positive with the instrument delivering a five-fold improvement in operational efficiency along with other key enhancements.
Raised an aggregate of $119 million in gross proceeds via an at-the-market equity (ATM) facility and a follow-on primary offering to fuel further innovation and commercial growth.
Acquired UmanDiagnostics AB, the preeminent developer of Nf-L protein antibodies. The acquisition positioned Quanterix to fully support and capitalize on the growing opportunities for Nf-L detection as it relates to the diagnosis, prognosis and monitoring of a wide range of conditions including Alzheimer’s disease, MS, Parkinson’s disease, traumatic brain injury, ALS, Huntington’s disease and others. This acquisition protects the Company’s strong leading Nf-L position and enhances its growth outlook.
Powered more than 85 percent of the Nf-L biomarker research presented at the American Academy of Neurology’s Annual Meeting and nearly 50 publications at the 35th Congress of the European Committee for Treatment and Research in Multiple Sclerosis (ECTRIMS) with its Simoa technology.
Increased publications dramatically by 238, bringing the total to 600 (over 65 percent growth).
Entered into multiple license and supply arrangements for access to Quanterix’ proprietary Nf-L antibodies. The Siemens Healthineers arrangement, marks a critical step toward a clinically relevant Nf-L test for patients. In the second arrangement, Quanterix will supply Nf-L antibodies to Bio-Techne.
Extended the Company’s oncology footprint with the launch of the Simoa SP-X Imaging and Detection System, 10-Plex Simoa CorPlex Cytokine Panel, and broad menu of additional multiplex panels, offering researchers a robust and highly-sensitive solution to test the efficacy and toxicity of immuno-oncology based therapeutics.
Strengthened the Company’s leadership team with the election of Sarah Hlavinka to its Board of Directors, and hiring of Amol Chaubal as Chief Financial Officer, Tatiana Plavina, Ph.D.(formerly of Biogen) as Vice President of Clinical Biomarker Strategy, Hether Ide (formerly of Thermo Fisher Scientific) as Vice President of North American Sales, and Andy Keys (formerly of SomaLogic) as Vice President of Worldwide Pharma Service Sales.
Moved to a new headquarters in Billerica, Mass., which contains the Company’s CLIA-certified lab, Simoa Accelerator Lab and expanding workforce under one roof.
Was the lead sponsor of the fourth-annual Powering Precision Health Summit (PPH) held in Barcelona, a conference dedicated to addressing the critical role of biomarkers in eradicating diseases such as Alzheimer’s and cancer. The summit was sold out and created significant momentum for Quanterix products.
"This past year was a testament to what can be accomplished when you bring the right people, determination and technology together," continued Hrusovsky. "We are encouraged by how our growth catalysts have all lined up for 2020 and feel our market opportunity is compelling."

Webcast Information

To access the live webcast of Quanterix’ presentation at the 38th Annual J.P. Morgan Healthcare Conference on Wednesday, Jan. 15, 2020 at 4 p.m., PST, please visit View Source To access the subsequent Q&A session with Hrusovsky on Wednesday, Jan. 15, 2020 at 4:30 p.m., PST, please visit View Source Replays of the webcasts will be available for a limited period following the conference.