On November 30, 2020 WestPark Capital, Inc., a full-service investment bank and securities broker-dealer, reported the closing of the follow-on offering for its client Lixte Biotechnology Holdings, Inc. 1,200,000 units consisting of one share of common stock and one warrant were sold for a total of $5,700,000 in gross proceeds (Press release, Lixte Biotechnology, NOV 30, 2020, View Source [SID1234572008]). Lixte Biotechnology Holdings, Inc. began trading on The Nasdaq Capital Market ("Nasdaq") on Wednesday, November 25, 2020 under the trading symbols "LIXT" and "LIXTW".

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WestPark Capital, Inc. acted as the book-running manager.

Lixte Biotechnology Holdings, Inc.’s registration statement relating to the offering has been filed with, and declared effective by, the United States Securities and Exchange Commission.

The offering was made pursuant to an effective registration statement on Form S-1 (No. 333-248588) previously filed with the U.S. Securities and Exchange Commission (the "SEC") and declared effective by the SEC on November 19, 2020. A final prospectus describing the terms of the proposed offering was filed with the SEC and may be obtained, when available, via the SEC’s website at www.sec.gov or from: WestPark Capital, Inc. – Attention: Jason Stern, 1900 Avenue of the Stars, 3rd Floor, Los Angeles, CA 90077 or by Email: [email protected] or by telephone at (310) 203-2919.

This press release does not constitute an offer to sell or the solicitation of an offer to buy these securities, nor shall there be any sale of these securities in any state or jurisdiction in which such offer, solicitation or sale would be unlawful prior to registration or qualification under the securities laws of that state or jurisdiction.

On November 30, 2020 CTI BioPharma Corp. (Nasdaq: CTIC) reported that an article highlighting pacritinib data was published in Blood Advances (Press release, CTI BioPharma, NOV 30, 2020, View Source [SID1234572006]). The article, titled "Determining the Recommended Dose of Pacritinib: Results from the PAC203 Phase 2 Dose-Finding Study in Patients with Advanced Myelofibrosis" is available online via this link.

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"Having recently announced the start of a rolling NDA submission for pacritinib as a treatment for myelofibrosis patients with severe thrombocytopenia, a patient population with reduced survival and limited therapeutic options, we continue to be committed to adding to the growing body of evidence underscoring the efficacy and safety profile of pacritinib," said Adam R. Craig, M.D., Ph.D., President and Chief Executive Officer of CTI Biopharma. "As our application will consist of a data package from the PERSIST-1, PERSIST-2 and PAC203 Phase 2 trials, with the ongoing Phase 3 PACIFICA trial expected to be completed as a post-marketing commitment, the data published today support our belief that pacritinib has the potential to become an important treatment in this disease setting, pending regulatory approval."

PAC203 Phase 2 was an open-label, randomized, dose-finding trial of pacritinib in patients with myelofibrosis who were previously treated with ruxolitinib. Patients were randomized 1:1:1 to pacritinib 100 mg daily (QD), 100 mg BID, or 200 mg BID. The trial demonstrated that pacritinib 200 mg BID had a favorable benefit risk profile. Spleen volume response (SVR) rates were highest among patients treated with pacritinib 200 mg BID who had a baseline platelet count of less than 50 x 109/L. Overall, the study data supported the selection of the pacritinib 200 mg BID for use in the ongoing Phase 3 PACIFICA study of pacritinib in patients with myelofibrosis with severe thrombocytopenia.

About Pacritinib

Pacritinib is an investigational oral kinase inhibitor with specificity for JAK2, IRAK1, and CSF1R. The JAK family of enzymes is a central component in signal transduction pathways, which are critical to normal blood cell growth and development, as well as inflammatory cytokine expression and immune responses. Mutations in these kinases have been shown to be directly related to the development of a variety of blood-related cancers, including myeloproliferative neoplasms, leukemia and lymphoma. In addition to myelofibrosis, the kinase profile of pacritinib suggests its potential therapeutic utility in conditions such as acute myeloid leukemia (AML), myelodysplastic syndrome (MDS), chronic myelomonocytic leukemia (CMML), and chronic lymphocytic leukemia (CLL), due to its inhibition of c-fms, IRAK1, JAK2 and FLT3.

On November 30, 2020 Regeneron Pharmaceuticals, Inc. (NASDAQ: REGN) reported that it will host a webcast on Monday, December 7, 2020 at 4:30pm EST (Press release, Regeneron, NOV 30, 2020, View Source [SID1234572005]). Management will discuss data presented at the American Society of Hematology (ASH) (Free ASH Whitepaper) 2020 Annual Meeting as well as provide updates on the Company’s broader oncology and hematology portfolio.

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Conference Call Information
To access this call, dial (888) 660-6127 (U.S.) or (973) 890-8355 (International), conference ID 7442859. A link to the webcast may be accessed from the ‘Investors and Media’ page of Regeneron’s website at View Source A replay of the conference call and webcast will be archived on the Company’s website for at least 30 days.

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On November 30, 2020 Thermo Fisher Scientific Inc. (NYSE: TMO), the world leader in serving science, reported that Marc N. Casper, chairman, president and chief executive officer, will present virtually at the Evercore ISI HealthCONx Conference on Tuesday, December 1, 2020, at 1:00 p.m. (EST) (Press release, Thermo Fisher Scientific, NOV 30, 2020, https://www.prnewswire.com/news-releases/thermo-fisher-scientific-to-present-at-the-evercore-isi-healthconx-conference-on-december-1-2020-301181393.html [SID1234572004]). Among other topics, Mr. Casper will provide the company’s current perspective on the impact of the COVID-19 pandemic and expectations for future financial performance.

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You can access the live webcast of the presentation via the Investors section of our website, www.thermofisher.com.