On October 1, 2020 C4 Therapeutics, Inc. (C4T) (Nasdaq: CCCC), a biopharmaceutical company pioneering a new class of small-molecule drugs that selectively destroy disease-causing proteins through degradation, reported the pricing of its upsized initial public offering of 9.6 million shares of common stock at a public offering price of $19 per share, before underwriting discounts and commissions, for gross proceeds of $182.4 million (Press release, C4 Therapeutics, OCT 1, 2020, View Source [SID1234567980]). All shares of common stock are being offered by C4T. The shares are expected to begin trading on the Nasdaq Global Market on October 2, 2020, under the symbol "CCCC." The offering is expected to close on October 6, 2020, subject to the satisfaction of customary closing conditions. Additionally, C4T has granted the underwriters a 30-day option to purchase up to an additional 1.44 million shares of common stock at the initial public offering price, less underwriting discounts and commissions.

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Jefferies, Evercore ISI, BMO Capital Markets and UBS Investment Bank are acting as joint book-running managers for the offering.

A registration statement relating to these securities became effective on October 1, 2020. The offering will be made only by means of a prospectus, copies of which may be obtained from Jefferies LLC, Attention: Equity Syndicate Prospectus Department, 520 Madison Avenue, 2nd Floor, New York, NY 10022, or by telephone at (877) 821 7388, or by email at [email protected]; or from Evercore Group L.L.C., Attention: Equity Capital Markets, 55 East 52nd Street, 36th Floor, New York, NY 10055, or by telephone at (888) 474 0200, or by email at [email protected]; or from BMO Capital Markets Corp. at 3 Times Square, 25th Floor, New York, NY 10036, Attention: Equity Syndicate Department, or by telephone at (800) 414-3627, or by email to [email protected]; or from UBS Securities LLC, Attention: Prospectus Department, 1285 Avenue of the Americas, New York, New York 10019, or by telephone at (888) 827-7275, or by e-mail at [email protected].

This press release shall not constitute an offer to sell or the solicitation of an offer to buy, nor shall there be any sale of these securities in any state or jurisdiction in which such offer, solicitation or sale would be unlawful prior to registration or qualification under the securities laws of any such state or jurisdiction.

On October 1, 2020 Sumgen Biotech of Hangzhou reported that it completed a $32 million Series B funding round to advance its portfolio of novel immunotherapy antibodies (Press release, Hangzhou Shangjian Biotechnology, OCT 1, 2020, View Source [SID1234567967]). The round was led by Addor Capital and co-led by Cowin Capital and Sinowisdom Investment. The proceeds will be used to fund clinical trials of the company’s pipeline of ten oncology mAbs and construction of an antibody production facility in Hangzhou. Also participating in the round were BOCOM International, Shanghai Haoshuo Investment and Dynamic Capital.

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On October 1, 2020 Simbec-Orion reported a charter agreement between the Oncodistinct Network and Simbec-Orion. The agreement strengthens the relationships between Simbec-Orion and the Oncodistinct network of oncology sites, who partner in operations and scientific expertise in the design and conduct of international early phase oncology trials (Press release, Simbec-Orion, OCT 1, 2020, View Source [SID1234567953]).

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"As a full-service agile Oncology CRO, dedicated to high quality delivery, the partnership between the Oncodistinct Network and Simbec-Orion provides benefits to both sponsors and patients," says Fabrice Chartier CEO at Simbec-Orion.

The Oncodistinct network is committed to accelerating oncology drug development and innovative strategies in clinical and translational research.

"This partnership with Simbec-Orion aligns with our network’s principles and activities, and underscores our commitment to innovative clinical research" says Professor Ahmad Awada from Oncodistinct.

The benefits of this agreement will include:

Streamlining of process and communication between sites, Simbec-Orion and sponsors to drive efficiencies in the setup and delivery of trials including the reduction of administrative burden in confidentiality agreements, feasibility efforts and contract negotiation
Commitment to fast-track feasibility within five working days of receipt
Expert and strategic advice on study design, protocol review and development

On October 1, 2020 CNS Pharmaceuticals, Inc. (NASDAQ: CNSP) ("CNS" or the "Company"), a biopharmaceutical company specializing in the development of novel treatments for primary and metastatic cancers of the brain and central nervous system, reported that the Company’s GMP manufacturer partner NCK A/S, received a Certificate of Analysis (CoA) for its Active Pharma Ingredient (API), clearing it for use in the production of Berubicin (Press release, CNS Pharmaceuticals, OCT 1, 2020, View Source [SID1234567943]).

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As previously announced, CNS signed a contract with NCK A/S for the large-scale production of Berubicin, its lead drug candidate for the treatment of glioma brain tumors. NCK A/S is a GMP manufacturer of complex drugs located in Farum, Denmark, and the previous producer of Berubicin for Reata Pharmaceuticals. NCK A/S production of Berubicin should ensure drug availability through the end of Phase 2 clinical trials for glioblastoma.

"We believe the execution of this critical manufacturing milestone positions the company advantageously ahead of our expected U.S. Phase 2 trial," stated John Climaco, CEO of CNS Pharmaceuticals. "Our partnerships have proven instrumental in further progressing the manufacturing process necessary to continue the clinical development of our lead candidate. We look forward to continuing the work underway and to initiating our U.S. Phase 2 trial in Q1 of 2021."

On October 1, 2020 Biocept, Inc. (Nasdaq: BIOC), a leading commercial provider of molecular diagnostic assays, products and services designed to provide physicians with clinically actionable information to improve patient outcomes, reported the upcoming presentation of results from a prospective study using its Target Selector testing of the cerebrospinal fluid in patients with non-small lung cancer (NSCLC) (Press release, Biocept, OCT 1, 2020, View Source [SID1234567940]). The study results will be discussed in a poster presentation at the International Association for the Study of Lung Cancer (IASLC) Virtual Lung Cancer Hot Topic Meeting: Liquid Biopsy by David Berz, MD, PhD, MPH of the Beverly Hills Cancer Center, on October 2 from 2:30-3:30 p.m. Eastern time.

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Central nervous system involvement by metastasis occurs in 3% to 4% of patients with NSCLC and 9% of NSCLC patients with EGFR mutations. Involvement of the lepto-meninges, thin membranous connective tissue layers with blood vessels that surround the brain and spinal cord, accounts for deteriorating neurologic function, mental status changes and poor prognosis in these patients, but can be difficult to diagnose with current methods.

This prospective study evaluated results from Biocept’s combined circulating tumor cell (CTC) and circulating tumor DNA (ctDNA) liquid biopsy testing compared to conventional cytology examination, the current standard-of-care, for confirming the diagnosis of leptomeningeal metastases in patients with EGFR-mutated NSCLC undergoing treatment with Tesevatinib, an experimental EGFR tyrosine kinase inhibitor (NCT02616393).

"Testing the cerebrospinal fluid of patients for metastases to the central nervous system is a key component of our oncology testing business," said Michael Nall, President and CEO of Biocept. "We are excited that Dr. Berz, a national thought leader in lung malignancies and personalized oncology treatment, will present these results at the IASLC conference which features the latest developments in cancer treatment including liquid biopsy clinical utility."

About the IASLC 2020 Lung Cancer Hot Topic Meeting: Liquid Biopsy

There have been numerous advances in liquid biopsy since this event’s advent in 2018, and the concept of a "blood-first" approach—superseding or replacing tissue biopsy—is a current topic of much debate and discussion. This innovative virtual conference will bring together international and multidisciplinary experts in the field of liquid biopsy in lung cancer to present and discuss current technology and best practices for clinical applications based on available data.

About the IASLC

The International Association for the Study of Lung Cancer (IASLC) is the only global organization dedicated solely to the study of lung cancer and other thoracic malignancies. Founded in 1974, the association’s membership includes nearly 9,000 lung cancer specialists across all disciplines in over 100 countries, forming a global network working together to conquer lung and thoracic cancers worldwide. The association also publishes the Journal of Thoracic Oncology, the primary educational and informational publication for topics relevant to the prevention, detection, diagnosis and treatment of all thoracic malignancies. Please visit www.iaslc.org for more information.