Tavanta Therapeutics, New Specialty Pharmaceutical Company, Has Diverse Pipeline of Novel Drugs and Risk-Balanced Approach to Product Development

On September 1, 2020 Tavanta Therapeutics, a specialty pharmaceutical company with global headquarters in the Philadelphia, Pennsylvania area, reported its reorganization from Druggability Technologies Holdings Ltd (Hungary) (Press release, Tavanta Therapeutics, SEP 1, 2020, View Source [SID1234564264]). Focused on long-term growth, Tavanta has established a leadership team with a long and successful track record in the development and commercialization of novel specialty drugs.

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"Completing the reorganization of key operational areas of the Company and optimizing our portfolio for strong, sustained growth in the United States have been critical steps for Tavanta," said Chief Executive Officer of Tavanta Therapeutics, Lynne Powell. "We have established a diverse, high-performing leadership team. Each member has enormous breadth and depth of experience and together we look forward to bringing new therapeutic solutions to patients and building value for our stakeholders."

Tavanta Therapeutics has embraced a vibrant, values-based culture that centers on creativity and experience. The name "Tavanta" is a reference to the Company’s commitment to advancing therapeutics designed to improve the lives of patients who have unmet medical needs.

Tavanta uses strategic partnerships early in the drug candidate identification process through in-licensing of drug targets to complement its own internally developed pipeline. The Company also seeks collaborative relationships for the development and commercialization of certain clinical candidates and welcomes inquiries from interested parties.

About the Tavanta Therapeutics Technology Platforms
Tavanta Therapeutics takes a risk-balanced approach to discovery and product development, deploying in-house platforms both to enhance the clinical performance of established molecules and to synthesize novel small molecules and therapeutic peptides. The result is a business model designed to lower the risk associated with the early stages of drug development, aimed toward accelerating new drug candidates into the clinic to reach patients with unmet medical needs.

Tavanta has established two platforms to support the rapid screening, identification and design of drug products for clinical development: High Throughput (HT) Matrix Screening Platform, and the Peptide Conjugate Development (PCD) Platform. The proprietary HT Matrix Screening platform is a bottom-up approach to improving the pharmacokinetic properties of poorly soluble pharmaceuticals, leading to the enhancement of certain important product characteristics. The PCD Platform is an integration of in-vitro and pre-clinical in-vivo testing designed to screen, characterize and design new peptides and peptide conjugates.

At the point at which candidate therapeutics are identified, Tavanta uses established pathways to support focused clinical development and regulatory approval. In the United States, these include both the standard 505(b)(1) and the expedited 505(b)(2) new drug application.

VolitionRx Limited to Present at Conferences in September 2020

On September 1, 2020 VolitionRx Limited (NYSE AMERICAN: VNRX) ("Volition") reported that its Chief Executive Officer, Cameron Reynolds, and its Executive Vice President, Investor Relations, Scott Powell, are scheduled to present at five conferences in September 2020 (Press release, VolitionRX, SEP 1, 2020, https://www.prnewswire.com/news-releases/volitionrx-limited-to-present-at-conferences-in-september-2020-301121771.html [SID1234564263]).

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During the conferences, Mr. Reynolds and Dr. Powell will outline Volition’s business, clinical, regulatory and operational milestones, as well as the Company’s recently announced quarterly financial results.

Details of the conference presentations (all virtual) are as follows:

Conference: LD Micro 500 Virtual Conference
Presentation Date/Time: Tuesday, September 1, 2020, 9:00 am EDT
Registration Link: View Source

Conference: GCFF Virtual Conference – Investing in Innovation
Presentation Date/Time: Thursday, September 10, 2020, 12:00 pm EDT
Registration Link: View Source

Conference: Cantor Virtual Global Healthcare Conference
Presentation Date/Time: Tuesday, September 15, 2020, 8:00 am EDT
Registration Link: https://cantor-fitzgerald-global-healthcare-conference.events.issuerdirect.com/signup

Conference: Life Sciences Investor Forum
Presentation Date/Time: Thursday, September 17, 2020, 10:00 am EDT
Registration Link: https://bit.ly/30GjErk

Conference: Oppenheimer Fall Healthcare Life Sciences & MedTech Summit
Presentation Date/Time: Monday, September 21, 2020, 10:50 am EDT
Registration Link: View Source summit.aspx

Participants joining any of the above-referenced conferences who would like to schedule a virtual 1-on-1 meeting with Volition management may do so by registering at the links above, or by contacting Scott Powell, Executive Vice President of Investor Relations, at [email protected].

OPKO Health’s BioReference Laboratories Launches Best-in-Class Next-Generation Sequencing (NGS) Assay

On September 1, 2020 BioReference Laboratories, Inc., an OPKO Health company (NASDAQ:OPK), along with its specialty oncology division, GenPath, reported the launch of OnkoSight AdvancedTM, a next-generation sequencing (NGS) assay that enables revolutionary deoxyribonucleic acid (DNA) mutational profiling of tumor samples (Press release, Opko Health, SEP 1, 2020, View Source [SID1234564262]).

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OnkoSight Advanced NGS testing provides targeted gene content that is aligned with the latest National Comprehensive Cancer Network (NCCN) and World Health Organization (WHO) guideline recommendations, to provide critical insights into many of the most common cancer types. Additionally, OnkoSight Advanced panels each include key biomarkers: Tumor Mutation Burden (TMB) and Tumor-Only Microsatellite (MSI), which are critical when profiling advanced stage tumor malignancies to guide potential immunotherapy.

"OnkoSight Advanced NGS panels are tumor-type specific and optimized to exclude extraneous gene content, significantly improving clinical actionability and relevance of the data to effectively guide real-world oncology patient management," said Bevan Tandon, M.D., Hematopathologist and Molecular Pathologist, Director of Cancer Genomics at BioReference Laboratories. "Coupled with BioReference and GenPath’s comprehensive oncology test menu, OnkoSight Advanced empowers physicians to make informed decisions effectively and efficiently."

"A cancer diagnosis and treatment path are difficult to address with patients and their families, which drives the importance of understanding a patient’s risk group and accurately diagnosing the type of cancer, to result in a targeted treatment strategy and prognosis assessment," said Jon R. Cohen, M.D., Executive Chairman of BioReference Laboratories. "The latest advancement from BioReference’s oncology division underscores the commitment to patient-centric care through our industry-leading result turnaround time with enhanced accuracy."

NCCN Oncology Research Program, with Taiho Oncology, to Explore New Research into Oral Medication Targeting Tumor Suppression Genes

On September 1, 2020 The National Comprehensive Cancer Network (NCCN) Oncology Research Program (ORP) reported plans to develop a program to scientifically evaluate and facilitate clinical trials on the efficacy of decitabine and cedazuridine (Press release, NCCN, SEP 1, 2020, View Source [SID1234564261]). This novel, fixed dose combination of the hypomethylating agent decitabine, combined with the cytidine deaminase inhibitor cedazuridine permits effective oral administration of decitabine by preventing degradation in the gut and liver. Studies will investigate decitabine and cedazuridine in hematologic malignancies. Research funding will be provided by a $2 million grant from Taiho Oncology.

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"Patients and advocates frequently express preference for oral medications over intravenous infusions," said Wui-Jin Koh, MD, Chief Medical Officer, NCCN. "By learning more about how patients with various cancer types respond to this kind of treatment when it’s delivered in an oral dosage form, we have the potential to make great strides in improving comfort, convenience, treatment adherence, and hopefully cure rates."

"The National Comprehensive Cancer Network’s research on decitabine and cedazuridine tablets can provide important insights regarding oral treatment options for patients with hematologic malignancies that can be taken from their home," said Martin J. Birkhofer, MD, Senior Vice President and Chief Medical Officer, Taiho Oncology, Inc. "We thank NCCN for expanding the generation of clinical data for decitabine and cedazuridine in patients with hematologic malignancies. This research is significant as both patients and healthcare providers look to reduce the number of in-office visits required for intravenous administration of their treatment during the current global pandemic."

The specific tumor types to be targeted for study will be determined by a group of cancer research specialists from NCCN Member Institutions who form the Request for Proposals (RFP) Development Team. The RFP will be shared in the coming months, with an announcement of selected projects to follow.

The NCCN ORP fosters innovation and knowledge discovery that improves the lives of people with cancer and supports preclinical, translational, clinical research and quality improvement projects in oncology at NCCN Member Institutions. In an effort to improve collaboration in cancer research, the NCCN ORP also maintains a shared resources website and an informed consent database. For more information, visit NCCN.org/orp.

Benitec Biopharma to present at H.C. Wainwright’s 22nd Annual Global Investment Conference

On September 1, 2020 Benitec Biopharma, Inc. (NASDAQ: BNTC), a development-stage, gene therapy-focused, biotechnology company developing novel genetic medicines based on the proprietary DNA-directed RNA interference ("ddRNAi") platform, reported that Jerel A. Banks, M.D., Ph.D., Executive Chairman and Chief Executive Officer of Benitec Biopharma will present at the H.C. Wainwright 22nd Annual Global Investment Conference (Press release, Benitec Biopharma, SEP 1, 2020, https://www.prnewswire.com/news-releases/benitec-biopharma-to-present-at-hc-wainwrights-22nd-annual-global-investment-conference-301121597.html [SID1234564260]). The relevant details are outlined below:

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Date: Wednesday, September 16, 2020
Event: H.C. Wainwright 22nd Annual Global Investment Conference
Time: 11:30 A.M. EDT
Webcast Link: View Source

Please visit the link above to register for the presentation which will be presented via webcast during the virtual conference. The presentation will also be streamed on the Investor Relations section of the Company’s website, View Source, and a copy of the presentation will be released to Nasdaq and posted on the Company’s website at the above URL prior to the event.

If you would like to arrange a virtual 1×1 meeting with Jerel A. Banks, M.D., Ph.D., Executive Chairman and Chief Executive Officer of Benitec after the presentation, please contact the Benitec IR Team using the details below.