Atara Biotherapeutics to Participate at Two Upcoming Conferences

On June 4, 2020 Atara Biotherapeutics, Inc. (Nasdaq: ATRA), a pioneer in T-cell immunotherapy leveraging its novel allogeneic EBV T-cell platform to develop treatments for patients with severe diseases including solid tumors, hematologic cancers and autoimmune disease, reported that Pascal Touchon, the Company’s President and Chief Executive Officer, will participate at two upcoming virtual conferences in June (Press release, Atara Biotherapeutics, JUN 4, 2020, View Source [SID1234560880]).

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Goldman Sachs 41st Annual Global Healthcare Conference
Video Fireside Chat: Thursday, June 11, 2020 at 3:50 p.m. EDT

A live video webcast of the Goldman Sachs presentation will be available by visiting the Investor Events and Presentations section of atarabio.com. An archived replay will be available on the Company’s website for approximately 14 days following the live webcast.

BIO Digital
Company Presentation: available on-demand via the BIO website, June 8-12, 2020

Aileron Therapeutics Announces Pricing of Public Offering of Common Stock

On June 4, 2020 Aileron Therapeutics (NASDAQ: ALRN) reported that the pricing of an underwritten public offering of 9,090,910 shares of its common stock at a public offering price of $1.10 per share, for aggregate gross proceeds of $10.0 million, before deducting underwriting discounts and commissions and offering expenses payable by Aileron (Press release, Aileron Therapeutics, JUN 4, 2020, View Source [SID1234560864]). In addition, Aileron has granted the underwriter a 30-day option to purchase up to 1,363,636 additional shares of common stock at the public offering price, less the underwriting discounts and commissions. All of the shares are being sold by Aileron. The offering is expected to close on June 8, 2020, subject to the satisfaction of customary closing conditions.

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Aileron expects to use the net proceeds from the offering, together with its existing cash, cash equivalents and short-term investments, to fund clinical development of ALRN-6924 as a chemoprotective agent and for working capital and other general corporate purposes.

William Blair & Company, L.L.C. is acting as sole book-running manager for the offering.

The shares are being offered pursuant to an effective shelf registration statement that was filed with the Securities and Exchange Commission (SEC) on July 1, 2019 and declared effective by the SEC on July 15, 2019.

This offering is being made only by means of a prospectus and prospectus supplement that form a part of the registration statement. A preliminary prospectus supplement relating to and describing the terms of the offering has been filed with the SEC and may be obtained for free by visiting the SEC’s website at www.sec.gov. The final prospectus supplemented relating to the offering will be filed with the SEC. When available, copies of the final prospectus supplement and the accompanying prospectus may also be obtained by contacting William Blair & Company, L.L.C., Attention: Prospectus Department, 150 North Riverside Plaza, Chicago, IL 60606, or by calling (800) 621-0687, or emailing [email protected].

This release does not constitute an offer to sell or the solicitation of an offer to buy the securities, nor shall there be any sale of the securities in any state in which such offer, solicitation or sale would be unlawful prior to the registration or qualification under the securities laws of such state.

AETERNA ZENTARIS RECEIVES EXTENSION FROM NASDAQ TO SATISFY CONTINUING LISTING REQUIREMENTS

On June 4, 2020 Aeterna Zentaris Inc. (NASDAQ: AEZS) (TSX: AEZS) ( the "Company"), a specialty biopharmaceutical company commercializing and developing therapeutics and diagnostic tests, reported that the Company has received a positive decision from the staff of the Listing Qualifications Department of The Nasdaq Stock Market LLC(the "Staff"), granting the Company’s request for an extension through October 5, 2020 to achieve compliance with the minimum $2.5 million stockholders’ equity requirement for continued listing on The Nasdaq Capital Market (Press release, AEterna Zentaris, JUN 4, 2020, View Source [SID1234560860]). The Staff’s determination followed the Company’s submission of its compliance plan for the Staff’s consideration on May 26, 2020.

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The Company is pursuing a number of initiatives to increase stockholders’ equity, the completion of which are expected to enable it to achieve compliance with the minimum stockholders’ equity requirement by no later than October 5, 2020 and to thereafter maintain compliance with the listing requirements.

Alpha Tau Medical Announces Successful Completion of New $26 Million Funding Round

On June 4, 2020 Alpha Tau Medical, the developer of breakthrough alpha-radiation cancer therapy Alpha DaRT, reported the closing of a Series B equity financing of $26 million (Press release, Alpha Tau Medical, JUN 4, 2020, View Source [SID1234560859]). Investors in the round included a mix of existing investors from previous rounds, such as Shavit Capital, Medison Ventures, and OurCrowd, who continue to demonstrate support for the clinical development of Alpha DaRT, as well as a number of new private and family office investors primarily from Israel and North America.

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During the last year, Alpha Tau successfully completed its first-in-human clinical trial of Alpha DaRT with squamous cell carcinoma patients from Italy and Israel. The impressive results from this study, published in the prestigious International Journal of Radiation Oncology, Biology, Physics (known as the "Red Journal") were subsequently applauded in this recent editorial in the same journal.

The Company is now conducting clinical trials in multiple clinical indications across the world, including its first US trial at Memorial Sloan Kettering Cancer Center in New York, a pancreatic cancer trial at CHUM in Montreal, and trials at three academic institutions in Japan. The Company is also establishing new global manufacturing facilities in Israel and elsewhere, and is in the middle of a process for CE marking for its first indication. These activities and others will be supported by the proceeds of this financing.

CEO Uzi Sofer commented, "We are humbled by the groundswell of continued support we’ve seen from both existing and new investors. This will enable us to push forward our mission to help cancer patients across the world, even during these challenging times in which COVID-19 is the focus of everyone’s health concerns."

CFO Raphi Levy added, "We have been very fortunate to continue our progress at full speed across all fronts, including R&D, clinical and operations, and now financing as well, even during a period of global turmoil. As concerns associated with systemic cancer therapies that affect the immune system have become more salient, we see strong interest in our trials from clinicians, patients, and investors who recognize the advantages of a focused and highly potent cancer therapy."

About AlphaDaRT

Alpha DaRT (Diffusing Alpha-emitters Radiation Therapy) enables highly potent and conformal alpha-irradiation of solid tumors. The treatment is delivered by intratumoral insertion of radium-224 impregnated seeds. When the radium decays, its short-lived daughters are released from the seed, and disperse while emitting high-energy alpha particles that destroy the tumor. Since the alpha-emitting atoms diffuse only a short distance, Alpha DaRT mainly affects the tumor, sparing the healthy tissue around it.

Protagonist Therapeutics to Present at the 25th European Hematology Association (EHA) Annual Congress

On June 4, 2020 Protagonist Therapeutics, Inc. (Nasdaq:PTGX) reported that the company will present data from its Phase 2 trial of PTG-300 for the treatment of beta-thalassemia at the 25th European Hematology Association (EHA) (Free EHA Whitepaper) Annual Congress, which will take place in a virtual format June 11-14, 2020 (Press release, Protagonist, JUN 4, 2020, View Source [SID1234560858]). Details of the oral presentation are as follows:

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Presentation Title: A hepcidin mimetic, PTG-300, demonstrates pharmacodynamic effects indicating reduced iron availability in transfusion-dependent beta-thalassemia subjects
Session: New therapeutic approaches for thalassemia
Abstract: S298
Date and Time: Available on the on-demand Virtual Congress platform on Friday, June 12, 2020, at 8:30 a.m. CEST