On May 28, 2020 ViewRay, Inc. (NASDAQ: VRAY) reported that the Company will present at the Jefferies 2020 Virtual Healthcare Conference (Press release, ViewRay, MAY 28, 2020, View Source [SID1234558644]). Scott Drake, President and CEO, will participate in a fireside chat at 2:30 p.m. Eastern Time on Tuesday, June 2, 2020.

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An audio webcast of the Company’s presentation will be available on the investor relations section of ViewRay’s website at View Source A replay of the webcast will be available for 7 days after the date of the presentation.

On May 28, 2020 Diaceutics reported new data insights into key areas of cancer testing (Press release, Diaceutics, MAY 28, 2020, View Source [SID1234558642]). In collaboration with the company’s network of industry advisors, the research has just been published in four abstracts and one poster at this year’s virtual American Society of Clinical Oncology (ASCO) (Free ASCO Whitepaper) conference. It exposes inefficiencies in precision medicine testing that are preventing patients from getting the treatment that they need, when they need it.

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Diaceutics’ ASCO (Free ASCO Whitepaper) research provides a snapshot of the breadth of testing issues that can be addressed through collaboration on the DXRX network. The value of this can be seen in its FLT3 research, for example: using a standard health economic model1, Diaceutics calculated that failure to test for FLT3 could lead to an economic burden in the US of $148 million to $445 million where Midostaurin could have been prescribed, and $139 million to $417 million where Giltertinib would have been the appropriate treatment.

Research Highlights

FLT32: Diaceutics examined the economic cost of not testing for FLT3 to treat acute myeloid leukemia (AML), a cancer with poor five-year survival rates and high treatment costs. The FDA approved two FLT3 precision medicines for AML in the last four years. Diaceutics found that these therapies can provide hope for AML patients and every year, 2,164 FLT3 patients in the US could benefit from precision medicine interventions, generating up to 2,965 quality-adjusted life years.
NTRK3: On a global scale, using the world’s largest repository of diagnostic testing data, Diaceutics’ research shows the dramatic variation in levels of test availability for NTRK between the EU, US and Asia. NTRK is one of the first hyper-targeted pan-tumor biomarkers which is dependent on the testing ecosystem. Diaceutics found that 73% of the top 30 labs in the US are carrying out NTRK fusion testing, compared to just 22% of Japan’s top nine; 54% of China’s top 13; 60% of Italy’s top 20 and 65% of France’s top 20.
HRD4: Diaceutics’ research team examined HRD, an emerging predictive biomarker across multiple cancers, and a companion biomarker for two new drug approvals this month. Diaceutics found that a lack of standardized HRD panels and low testing rates are leading to poorer outcomes for ovarian cancer patients who may have been eligible for PARP inhibitor treatment. Research was based on a data set of 8,400 metastatic ovarian cancer patients.
KRAS G12C5: Insights from the DXRX diagnostic network also provides market readiness analysis for prospective therapies targeting KRAS-G12C – an aggressive, poor survival tumor genotype – in lung, colorectal and pancreatic cancers. Analysis of Diaceutics’ data found that following treatment with first-line therapies, primary tumor profile results can be less reliable. The team concluded that there is a need for improved reimbursement and repeated testing post-treatment for the continued efficacy in therapeutics – especially for patients with pancreatic cancer.
TP536: Diaceutics studied a cohort of 984 patients diagnosed with Acute Myeloid Leukemia (AML). The study found that where there was a TP53 mutation detected, patients had negative associations with 7 specific genes (ASXL1, CEBPA, FLT3, IDH1, NRAS, RUN1, TET2), meaning that a TP53 antagonist and targeted therapy may be a valuable treatment option in rare cases where co-mutation exists.
Chief Technical Officer, Jordan Clark, said: "Our data consistently reveals that testing inefficiencies due to a lack of collaboration among precision medicine stakeholders remains today’s most significant obstacle to getting every patient the treatment they deserve.

"To address this need for collaboration, we have spent the last 10 years building relationships with more than 2,500 laboratories and industry leading service providers in areas such as pathology training, health economics, reference standards, EQA and digital enablement.

"DXRX by Diaceutics will unlock the power of our data for all members of this network, delivering significantly more value for all stakeholders in precision medicine and, most of all, for patients.

"Several of the abstract authors are industry advisors in the DXRX network, and these studies demonstrate the power of being able to facilitate the collaboration required to advance our mission of getting every patient the treatment they deserve."

Diaceutics will launch DXRX, the world’s first diagnostic network in precision medicine, in Q4 2020 to help solve these issues through global stakeholder collaboration.

Through DXRX, Diaceutics will make these alliances and its real-world data repository available to its network of pharmaceutical, laboratory and diagnostic partners. Laboratory and diagnostic partners will join the DXRX network in Q3 2020, and pharmaceutical partners will gain access in Q4.

DXRX is industry shorthand for diagnostics (DX) and therapy (RX). For more information visit View Source

Diaceutics’ published research is available at View Sourcedata-insights.html

On May 28, 2020 Sarah Cannon reported that it will present its latest cancer research insights at the American Society of Clinical Oncology (ASCO) (Free ASCO Whitepaper)’s (ASCO) (Free ASCO Whitepaper) Annual Meeting being held virtually May 29 – 31, 2020 (Press release, Sarah Cannon Research Institute, MAY 28, 2020, View Source [SID1234558641]). This year, Sarah Cannon’s drug development and research expertise is featured through more than 110 abstracts and presentations, including data from more than 50 phase 1 studies.

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The ASCO (Free ASCO Whitepaper)20 Virtual Meeting will bring together the largest community of oncology leaders worldwide to discuss pivotal clinical research that is influencing the latest care and treatment standards for patients facing cancer. This year’s event is being led by Sarah Cannon’s President of Clinical Operations and Chief Medical Officer, Howard A. "Skip" Burris III, MD, FACP, FACSO, who is serving as the 2020 ASCO (Free ASCO Whitepaper) President.

"When I chose my presidential theme to Unite and Conquer: Accelerating Progress Together, I never imagined what new meaning it would take over the course of this year, especially in the time of a global pandemic," says Dr. Burris. "In spite of recent challenges, we know that by bringing together oncologists, pharmacists, nurses, staff, lab techs, scientists, practice administrators and academic researchers, we are more united than ever with our patients to accelerate progress in the fight against cancer."

Dr. Burris will deliver this year’s presidential speech on Saturday, May 30 at 8:30 AM CT.

Melissa Johnson, MD, Sarah Cannon’s Associate Director of Lung Cancer Research and Drug Development, serves as this year’s ASCO (Free ASCO Whitepaper) Scientific Committee Chair, leading the scientific program at the meeting. In this role, Dr. Johnson will lead two key programs: the clinical science symposium on "Cancer Care in the Time of COVID: Assessing Impact and Future Direction" on Saturday, May 30 from 3:30-4:30 PM CT, and will also chair the Plenary Session on Sunday, May 31 from 12-2:30 PM CT.

A number of Sarah Cannon research leaders will also participate in the following educational and oral presentations:

Johanna Bendell, MD, Chief Development Officer and Director of the GI Cancer Research Program, will present "Phase I Monotherapy Dose Escalation of RGX-202, a First-In-Class Oral Inhibitor of the SLC6a8/CKB Pathway, in Patients with Advanced Gastrointestinal Solid Tumors" in an oral presentation. (Abstract 3504)
Jesus Berdeja, MD, Director of Myeloma Research and Senior Investigator of Hematologic Malignancies, is the discussant on the plenary session focused on "Carfilzomib, Lenalidomide, and Dexamethasone Versus Bortezomib, Lenalidomide, and Dexamethasone for Initial Therapy of Newly Diagnosed Multiple Myeloma" on Sunday, May 31 from 12-2:30 PM CT. Dr. Berdeja will also highlight data in an oral presentation on "Update of CARTITUDE-1: A Phase Ib/II Study of JNJ-4528, a B-Cell Maturation Antigen-Directed CAR-T-Cell Therapy, in Relapsed/Refractory Multiple Myeloma." (Abstract 8505)
Ian Flinn, MD, Director of Lymphoma Research, is the discussant during the poster presentation on "Reassessing PI3K Inhibitors in Indolent Lymphomas."
Stephanie Graff, MD, Director of the Breast Cancer Program and Clinical Research for Sarah Cannon Cancer Institute at HCA Midwest Health, is the discussant on the poster presentation of "Mind the Gap: Identifying Disparities and Actionable Insights."
Anthony Greco, MD, Co-founder of Sarah Cannon, is the discussant during the clinical science symposium on "Redefining Cancer of Unknown Primary: Is Genomics the Answer?" on Saturday, May 30, from 2:30-3:30 PM CT.
Erika Hamilton, MD, Director of the Breast Cancer and Gynecologic Cancer Research Program, will review key advancements in breast cancer research during the "Highlights of the Day" session on Saturday, May 30 9:30-10 AM CT.
Dr. Johnson will present "CX-2029, a PROBODY Drug Conjugate Targeting CD71 (Transferrin Receptor): Results from a First-In-Human Study in Patients with Advanced Cancer" and "Primary Analysis of a Randomized, Double-Blind, Phase II Study of the Anti-TIGIT Antibody Tiragolumab Plus Atezolizumab Versus Placebo Plus Atezo as First-Line Treatment in Patients with PD-L1-Selected NSCLC (CITYSCAPE)" in two oral presentations. (Abstract 3502, Abstract 9503)
Aravind Ramakrishnan, MD, Medical Director of the Bone Marrow Transplant and Cellular Therapy Program for Sarah Cannon Blood Cancer Center at St. David’s South Austin Medical Center, will present "Phase I Alexander Study of AUTO3, the First CD19/22 Dual Targeting CAR T-Cell Therapy, with Pembrolizumab in Patients with Relapsed/Refractory DLBCL" in an oral presentation. (Abstract 8001)
David Spigel, MD, Chief Scientific Officer and Director of the Lung Cancer Research Program, will be the discussant in a plenary session focused on "Osimertinib as Adjuvant Therapy in Patients with Stage IB–IIIA EGFR Mutation Positive NSCLC After Complete Tumor Resection: ADAURA" on Sunday, May 31, from 12-2:30 PM CT.
At the ASCO (Free ASCO Whitepaper)20 Virtual Meeting, posters with Sarah Cannon experts as first authors will be presented by:

Dr. Bendell will present on "First-In-Human Phase I Study of HPN424, a Tri-Specific Half-Life Extended PSMA-Targeting T-Cell Engager in Patients with Metastatic Castration-Resistant Prostate Cancer." (Abstract 5552)
Dr. Hamilton will present on "Clinical Activity of MCLA-128, Trastuzumab, and Vinorelbine in HER2 Amplified Metastatic Breast Cancer Patients who Had Progressed on Anti-HER2 ADCs." (Abstract 3093)
Dr. Johnson will present "Safety of BI 754111, an Anti-LAG-3 Monoclonal Antibody, in Combination with BI 754091, an Anti-PD-1 Mab, in Patients with Advanced Solid Tumors." (Abstract 3063)
Dr. Spigel will present in two posters on "Randomized Phase II Study of Pembrolizumab Alone Versus Pegilodecakin in Combination with Pembrolizumab as First-Line Therapy in Patients with Stage IV Non-Small Cell Lung Cancer with High PD-L1 Expression (CYPRESS 1)" and "RESILIENT Part I, an Open-Label, Safety Run-In of Liposomal Irinotecan in Adults with Small Cell Lung Cancer who Have Progressed with Platinum-Based First-Line Therapy: Subgroup Analyses By Platinum Sensitivity." (Abstract 9563, Abstract 9069)
Denise Yardley, MD, Senior Investigator of the Breast Cancer Research Program, will present on "Overall Survival in Patients with Advanced Breast Cancer with Visceral Metastases, Including Those with Liver Mets, Treated with Ribociclib Plus Endocrine Therapy in the MONALEESA -3 and -7 Trials." (Abstract 1054)
Manish Patel, MD, Director of Drug Development for Sarah Cannon Research Institute at Florida Cancer Specialists, will present on "A Phase I Study of mRNA-2752, a Lipid Nanoparticle Encapsulating mRNAs Encoding Human OX40L, IL-23, and IL-36γ, for Intratumoral Injection Alone and in Combination With Durvalumab." (Abstract 3092)
Carlos Bachier, MD, Director of Cellular Therapy Research, will present on "Outpatient Treatment with Lisocabtagene Maraleucel Across a Variety of Clinical Sites From Three Ongoing Clinical Studies in Relapsed/Refractory Large B-Cell Lymphoma." (Abstract 8037)
Debra Richardson, MD, Stephenson Cancer Center at the University of Oklahoma, will present on "Phase I Expansion Study of XMT-1536, a Novel NaPi2b-Targeting Antibody-Drug Conjugate: Preliminary Efficacy, Safety, and Biomarker Results in Patients with Previously Treated Metastatic Ovarian Cancer or Non-Small Cell Lung Cancer." (Abstract 3549)
Gerald Falchook, MD, MS, Director of Drug Development for Sarah Cannon Research Institute at HealthONE, will present on "Pen-866, a Miniature Drug Conjugate of a Heat Shock Protein 90 (HSP90) Ligand Linked To SN38 For Patients with Advanced Solid Malignancies: Phase I and Expansion Cohort Results." (Abstract 3515)
Elisa Fontana, MD, Clinical Research Fellow at Sarah Cannon Research Institute – UK, will present on "Neoadjuvant Chemoradiation for Locally Advanced Rectal Cancer With Or Without Oxaliplatin: Individual Patient Data Meta-Analysis of Three Randomized Controlled Trials with Subgroup Analyses of Age Cohorts." (Abstract 4074)
Andrew McKenzie, PhD, Senior Manager of Personalized Medicine, will present on "Clinical and Genomic Analysis of Non-Small Cell Lung Cancer Patients with MET Exon14 Skipping (METex14) Mutations and Responses To Anti-MET Therapy." (Abstract 9613)
The researchers represent Sarah Cannon’s global network of strategic sites:

Sarah Cannon Research Institute at Tennessee Oncology, Sarah Cannon Research Institute at Florida Cancer Specialists, Colorado Blood Cancer Institute, Sarah Cannon Blood Cancer Center at St. David’s South Austin Medical Center, Sarah Cannon Center for Blood Cancer at TriStar Centennial, Sarah Cannon Research Institute at HCA Midwest Health (Kansas City), Sarah Cannon Research Institute at HealthONE (Denver), Sarah Cannon Research Institute – United Kingdom, Sidney Kimmel Cancer Center at Jefferson Health, and The Stephenson Cancer Center at the University of Oklahoma.

On May 28, 2020 Humanetics Corporation (Humanetics) reported that an abstract reporting the results of a clinical trial of BIO 300 in non-small cell lung cancer patients undergoing radiochemotherapy has been selected for oral presentation at the annual meeting of the American Society for Radiation Oncology taking place virtually from October 25-28, 2020 (Press release, Humanetics, MAY 28, 2020, View Source [SID1234558640]). More than 3,300 abstracts were submitted to the premier international radiation oncology annual meeting, and Humanetics’s abstract was one of only 280 selected for this highest level of oral presentation.

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Dr. Charles B. Simone, II, MD, FACRO, Research Professor and Chief Medical Officer for the New York Proton Center, will be the presenting author of the multi-site phase 1b/2a study. The trial investigated the safety and efficacy of BIO 300, a novel drug candidate focused on mitigating toxicities to normal tissues commonly experienced by patients from radiotherapy.

Lung cancer is the most common cause of cancer-related deaths in the United States and affects nearly 230,000 individuals per year. Non-small cell lung cancer (NSCLC) is the most common type of lung cancer, comprising approximately 87% of all cases. A common treatment for NSCLC is radiotherapy, which is often accompanied by chemotherapy, particularly for stage II, III and limited-extent IV disease. However, radiation therapy can cause unwanted side effects to otherwise healthy tissue surrounding the tumor or in the path of the radiation beam. These effects include esophagitis, pulmonary pneumonitis and fibrosis, all of which limit patient quality of life, can contribute to lasting health problems, and, in severe cases, can be fatal.

"Drugs that can reduce or prevent the unwanted side effects of radiotherapy are a truly unmet need for patients," said Dr. Simone. "Radiotherapy is an important standard of care, and its use is forecast to grow. Drugs like BIO 300 have the potential to significantly improve the quality of life and outcomes for our patients." Dr. Simone served as one of the principal investigators for the BIO 300 clinical trial.

BIO 300 is an oral medication, taken once daily by patients prior to their radiation treatment. Its properties as a radioprotectant were discovered by researchers at the U.S. Department of Defense, where it was studied as a potential agent to be used by warfighters to prevent injury from radiation on the battlefield. Humanetics acquired the rights to the drug and has active development programs ongoing in both oncology and for biodefense.

On May 28, 2020 ITM Isotopen Technologien München AG (ITM), a biotechnology and radiopharmaceutical group of companies, reported the change of name of its subsidiary ITG Isotope Technologies Garching GmbH (Press release, ITM Isotopen Technologien Munchen, MAY 28, 2020, View Source [SID1234558639]). With effect from May 28, 2020, the company responsible specifically for the production of medical isotopes within the ITM Group will operate under the name ITM Medical Isotopes GmbH. The background to the decision is to present a uniform external image of the ITM group of companies, which, alongside ITM Medical Isotopes GmbH, includes among others the highly specialized companies ITM Oncologics GmbH and ITM Solucin GmbH.

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The change of name will have no other impact on business partners, customers and staff. The legal form of the company and the ownership structure will remain unchanged. The fields of activity of radioisotope production, the product portfolio and all contracts concluded up to the rebranding will remain unchanged under the new company name. The head office address, the commercial register number and all known contact partners will remain unchanged.

ITG Isotope Technologies Garching GmbH, or ITM Medical Isotopes GmbH, is a 100% subsidiary of ITM Isotopen Technologien München AG. Over the course of the company’s 16-year history, from a start-up housed on the Technical University of Munich (TUM) site, ITM has established itself as a worldwide biotechnology and radiopharmaceutical group of companies in Targeted Radionuclide Therapy with a global distribution network. ITM develops, produces and distributes radiopharmaceuticals and medical radioisotopes for the diagnosis and therapy of cancer. The current product portfolio and focus of research includes targeted candidates for the treatment of neuroendocrine tumors, glioblastoma, osteosarcoma and bone metastases, as well as folate receptor α positive tumors such as lung, ovarian or breast cancer.