Exact Sciences to participate in May investor conference

On May 4, 2020 Exact Sciences Corp. (Nasdaq: EXAS) reported that company management will participate in the following investor conference and invited investors to participate by webcast (Press release, Exact Sciences, MAY 4, 2020, View Source [SID1234556933]).

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BofA Securities Virtual Healthcare Conference
Fireside Chat on Wednesday, May 13, 2020, at 9:00 a.m. EDT
The webcast can be accessed in the investor relations section of Exact Sciences’ website at www.exactsciences.com.

Targovax Releases Update for Mesothelioma Trial Combining ONCOS-102 and Chemotherapy

On May 4, 2020 Targovax ASA (OSE: TRVX), a clinical stage immuno-oncology company developing oncolytic viruses to target hard-to-treat solid tumors, reported an update from the randomized phase I/II trial of ONCOS-102 in combination with standard of care chemotherapy in malignant pleural mesothelioma (Press release, Targovax, MAY 4, 2020, View Source [SID1234556931]).

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The trial is an open label, randomized, exploratory phase I/II trial adding ONCOS-102 to standard of care (SoC) chemotherapy (pemetrexed/cisplatin) in first and second (and later) line mesothelioma to assess safety, immune activation and clinical efficacy. In total, 31 patients have been enrolled with 20 patients in the experimental group receiving the ONCOS-102 and SoC, and 11 patients in a control group receiving SoC only. The first set of data was reported in January 2020, see link to press release here.

All patients have now completed the 9-month follow-up. The median Progression Free Survival (mPFS) remains in line with previously published data and compares favorably with historical control. The first line patients continue to perform well, and will be the population prioritized for future development. The updated PFS data are being complemented by biomarker analyses and early data demonstrate enhanced immune activation and modulation of tumor microenvironment in ONCOS-102-treated patients compared to the control group. 12-months clinical data as well as more extensive immune activation and biomarker data will be released in the middle of 2020.

Dr. Magnus Jäderberg, Chief Medical Officer of Targovax, said: "We are very pleased to see the encouraging early PFS figures holding up in the 9-month analysis. The data look particularly promising for first line patients, and the preparations for a subsequent checkpoint inhibitor combination trial in this population with a big pharma collaboration partner are progressing according to plan."

Ipsen enters into an option agreement with IRICoR and Université de Montréal for a discovery-stage oncology program

On May 4, 2020 Ipsen (Euronext: IPN; ADR: IPSEY), a global specialty-driven biopharmaceutical group, IRICoR, a pan-Canadian research commercialization center focused on drug discovery, and Université de Montréal, reported they entered into an option agreement by which Ipsen would acquire an exclusive license for the worldwide rights to a high-value oncology program (Press release, Ipsen, MAY 4, 2020, View Source [SID1234556930]).

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Under the leadership of Université de Montréal’s drug discovery unit based at the Institute for Research in Immunology and Cancer, the program, currently at lead optimization stage, will focus on advancing the current lead molecules to the development candidate stage. Université de Montréal/IRICoR will be responsible for conducting and financing the research program until the option to license is exercised. If Ipsen decides to exercise the option, Ipsen would assume all development activities and commercialize the drug candidate globally. The financial terms of the agreement, including research, development, commercial milestones and royalties have not been disclosed.

"At Ipsen, our mission is to improve patients’ lives by delivering on our growth strategy. Core to this strategy is identifying and pursuing early-stage assets with a potentially best-in-class value proposition so that we can develop new therapies for patients affected by cancer, neurological disorders and rare diseases," said Howard Mayer, EVP, Head of R&D, Ipsen. "We are very pleased to partner with IRICoR and Université de Montréal, whose reputation for scientific excellence in oncology is recognized internationally. Through this collaboration, we will bring together their strong scientific expertise and Ipsen’s drug development capabilities to further advance patient care in oncology."

"We are confident that this partnership has the potential to bring new, innovative therapeutic options to patients with high unmet medical need," said Dr. Steven Klein, Vice-President, Business Development, IRICoR. "Accelerating the development of novel early-stage oncology solutions is crucial to our mission of accelerating the discovery and development of innovative therapies in our targeted areas of cancer and related diseases by working with leading companies such as Ipsen to bring these new therapeutic options to patients suffering from cancer."

XNK Therapeutics names new CEO

On May 1, 2020 Johan Liwing, from Janssen (Johnson & Johnson), reported that it has been appointed new acting CEO at XNK Therapeutics. He is succeeding the former CEO Karin Mellström whom will retire, but remain disposable for the the company as Project Manager (Press release, CellProtect Nordic Pharmaceuticals, MAY 1, 2020, View Source [SID1234560777]). Johan Liwing has over 15 year’s of experience from leading positions within the Life science industry in Sweden as well as internationally. During his 13 years at Janssen (Johnson & Johnson), he has held various positions in health economics, sales & marketing, as well as observational research. In his most recent position at Janssen, as global senior director, he was responsible for the development and use of observational data.

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Arrowhead Pharmaceuticals to Participate in Upcoming May 2020 Conferences

On May 1, 2020 Arrowhead Pharmaceuticals Inc. (NASDAQ: ARWR) reported that it is scheduled to participate in the following upcoming events (Press release, Arrowhead Pharmaceuticals, MAY 1, 2020, View Source [SID1234556929]):

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Early/Late Stage Pipeline Development - Target Scouting - Clinical Biomarkers - Indication Selection & Expansion - BD&L Contacts - Conference Reports - Combinatorial Drug Settings - Companion Diagnostics - Drug Repositioning - First-in-class Analysis - Competitive Analysis - Deals & Licensing

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BofA Securities 2020 Health Care Conference– May 12-14, 2020

May 14, 11:00 a.m. EDT – Chris Anzalone, Ph.D., Arrowhead’s president and CEO, will deliver corporate presentation

RBC Global Healthcare Conference– May 19-20, 2020

May 20, 2:30 p.m. EDT – Dr. Anzalone will participate in a fireside chat presentation

A copy of the presentation materials and webcast links, if the presentation is being webcast, may be accessed on the Events and Presentations page under the Investors section of the Arrowhead website.