Corporate Presentation

On April 27, 2020 Verastem Presented the Corporate Presentation (Presentation, Verastem, APR 27, 2020, View Source [SID1234556636]).

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VBI Vaccines Announces Closing of Public Offering of Common Stock and
Full Exercise of Underwriters’ Option to Purchase Additional Shares

On April 27, 2020 VBI Vaccines Inc. (Nasdaq: VBIV) (VBI or the Company), a commercial-stage biopharmaceutical company developing next-generation infectious disease and immuno-oncology vaccines, reported the closing of its previously announced underwritten public offering and the exercise in full of the underwriters’ option to purchase additional shares (Press release, VBI Vaccines, APR 27, 2020, View Source [SID1234556635]). The gross proceeds from the offering, before deducting the underwriting discounts and commissions and estimated offering expenses payable by VBI, are approximately US$57.5 million. 52,272,726 common shares, at a public offering price of US$1.10 per share, were issued and sold in this offering, which includes 6,818,181 shares issued upon the exercise of the underwriters’ option to purchase additional shares.

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Immediately following the closing of the underwritten public offering, the number of outstanding common shares of the Company is 230,648,396.

Raymond James & Associates, Inc. and Oppenheimer & Co. Inc. acted as joint book-running managers, and National Securities Corporation, a wholly-owned subsidiary of National Holdings, Inc. (Nasdaq: NHLD), acted as lead manager for the underwritten public offering.

VBI intends to use the net proceeds from the offering to support the regulatory filings, pre-commercialization, and launch planning activities for Sci-B-Vac in the United States, Europe, and Canada, for the continued advancement of its pipeline programs, including the development of VBI-1901, a cancer vaccine immunotherapeutic candidate for recurrent glioblastoma (GBM); VBI-2601, an immunotherapeutic candidate for chronic hepatitis B infection; VBI-1501, a prophylactic cytomegalovirus (CMV) vaccine candidate; and VBI-2901, a prophylactic pan-coronavirus vaccine candidate. The net proceeds will also be used for general corporate purposes, including working capital and capital expenditures.

A shelf registration statement relating to the common shares was previously filed with the Securities and Exchange Commission (SEC) and declared effective on July 30, 2018. A preliminary prospectus supplement and accompanying prospectus relating to the underwritten public offering was filed with the SEC on April 21, 2020. A final prospectus supplement and accompanying prospectus, dated April 22, 2020, relating to the offering was filed with the SEC on April 24, 2020, and is available on the SEC’s website at www.sec.gov. Copies of the final prospectus supplement and accompanying prospectus may also be obtained from Raymond James & Associates, Inc., Attention: Equity Syndicate, 880 Carillon Parkway, St. Petersburg, Florida 33716, by telephone at (800) 248-8863, by e-mail at [email protected], or from Oppenheimer & Co. Inc., Attention: Syndicate Prospectus Department, 85 Broad Street, 26th Floor, New York, NY 10004 or by e-mail at [email protected].

This press release shall not constitute an offer to sell or the solicitation of an offer to buy these securities, nor shall there be any sale of these securities in any state or other jurisdiction in which such offer, solicitation or sale would be unlawful prior to registration or qualification under the securities laws of any such state or other jurisdiction. Any offer, if at all, will be made only by means of the prospectus supplement and accompanying prospectus forming a part of the effective registration statement.

Entry into a Material Definitive Agreement

On April 27, 2020, Sorrento Therapeutics, Inc. (the "Company") reported that entered into a Sales Agreement (the "Sales Agreement") with A.G.P./Alliance Global Partners, as sales agent (the "Agent"), pursuant to which the Company may offer and sell, from time to time, through or to the Agent, as sales agent and/or principal (the "Offering") up to $250,000,000 in shares of its common stock (the "Shares") (Filing, 8-K, Sorrento Therapeutics, APR 27, 2020, View Source [SID1234556634]). Any Shares offered and sold in the Offering will be issued pursuant to the Company’s Registration Statement on Form S-3 (File No. 333-237142) filed with the Securities and Exchange Commission (the "SEC") on March 13, 2020 and declared effective on March 20, 2020 (the "Form S-3"), the base prospectus dated March 20, 2020 included in the Form S-3 and the prospectus supplement relating to the Offering, dated April 27, 2020, that will be filed with the SEC.

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Subject to the terms and conditions of the Sales Agreement, the Agent will use its commercially reasonable efforts to sell the Shares from time to time, based upon the Company’s instructions. Under the Sales Agreement, the Agent may sell the Shares by any method permitted by law deemed to be an "at the market offering" as defined in Rule 415 promulgated under the Securities Act of 1933, as amended (the "Securities Act").

The Company has no obligation to sell any of the Shares, and may at any time suspend offers under the Sales Agreement. The Offering will terminate upon (a) the election of the Agent upon the occurrence of certain adverse events, (b) three business days’ advance notice from one party to the other, or (c) the sale of all of the Shares.

Under the terms of the Sales Agreement, the Agent will be entitled to a commission at a fixed rate of 3.0% of the gross proceeds from each sale of Shares under the Sales Agreement. The Company will also reimburse the Agent for certain expenses incurred in connection with the Sales Agreement, and agreed to provide indemnification and contribution to the Agent with respect to certain liabilities, including liabilities under the Securities Act and the Securities Exchange Act of 1934, as amended.

The Company currently intends to use any net proceeds from the Offering for working capital and general corporate purposes, which may include capital expenditures, research and development expenditures, regulatory affairs expenditures, clinical trial expenditures, acquisitions of new technologies and investments, business combinations and the repayment, refinancing, redemption or repurchase of indebtedness or capital stock. The Company may use a portion of the proceeds to repay indebtedness owed under that certain Term Loan Agreement that the Company and certain of its domestic subsidiaries entered into with certain funds affiliated with Oaktree Capital Management, L.P. and Oaktree Fund Administration, LLC, as administrative and collateral agent, as amended.

The foregoing description of the Sales Agreement does not purport to be complete and is qualified in its entirety by reference to the full text of the Sales Agreement, a copy of which is filed as Exhibit 1.1 hereto and is incorporated herein by reference.

This Current Report on Form 8-K shall not constitute an offer to sell or the solicitation of an offer to buy the Shares, nor shall there be any offer, solicitation or sale of the Shares in any state or country in which such offer, solicitation or sale would be unlawful prior to registration or qualification under the securities laws of any such state or country.

Common Stock Purchase Agreement

On April 27, 2020, the Company entered into a Common Stock Purchase Agreement (the "Purchase Agreement") with Arnaki Ltd., a British Virgin Islands corporation (the "Purchaser"), pursuant to which the Purchaser is committed to purchase up to an aggregate of $250.0 million of shares of the Company’s common stock ("Common Stock") over the 36-month term of the Purchase Agreement on the terms set forth therein (the "CSPA Offering").

The Company will file with the SEC a prospectus supplement to the Form S-3, dated April 27, 2020, registering all of the shares of Common Stock that may be offered and sold to the Purchaser pursuant to the Purchase Agreement from time to time.

Pursuant to the terms of the Purchase Agreement, on any business day over the 36-month term of the Purchase Agreement (each, a "Purchase Date"), the Company has the right, in its sole discretion, to present the Purchaser with a purchase notice (each, a "Purchase Notice") directing the Purchaser to purchase up to 650,000 shares of Common Stock per business day. The Company and the Purchaser also may mutually agree to increase the number of shares that may be sold to as much as an additional 3,600,000 shares per Purchase Date. In addition to such purchases, the Company has the right, in its sole discretion, to grant the Purchaser an option to purchase an additional amount of shares of Common Stock, subject to a maximum number of shares determined by the Company on each Purchase Date. Pursuant to the Purchase Agreement, in no event shall the aggregate purchase price paid by the Purchaser exceed $5,000,000 per Purchase Date, unless mutually agreed by the Company and the Purchaser. The purchase price of the Common Stock pursuant to the Purchase Agreement will be equal to 97.5% of the daily volume weighted average purchase price of the Common Stock on the Purchase Date (the "Purchase Price").

The Purchaser will not be required to, but may at its option, buy shares of Common Stock pursuant to a Purchase Notice that was received by the Purchaser on any day on which either (i) the daily volume-weighted average purchase price of the Common Stock is below $1.10 (which shall not be subject to adjustment for any reorganization, recapitalization, stock dividend, stock split, reverse stock split or other similar transaction), or (ii) the Purchase Price for such day is below $1.10 per share. The Purchaser has no right to require any sales by the Company, but is obligated to make purchases from the Company as directed by the Company in accordance with the Purchase Agreement. There are no limitations on the use of proceeds, financial or business covenants, restrictions on future financings, rights of first refusal, participation rights, penalties or liquidated damages in the Purchase Agreement. The Company may terminate the Purchase Agreement at any time, in the Company’s discretion, without any cost or penalty. The Purchaser may terminate the Purchase Agreement at any time that an event of default exists without any liability or payment to the Company. Pursuant to the Purchase Agreement, the Purchaser agreed that during the term of the Purchase Agreement, neither it nor any of its affiliates or any entity managed or controlled by it will, directly or indirectly, engage in any short sales involving the Company’s securities or grant an option to purchase, or acquire any right to dispose of or otherwise dispose for value of, any shares of Common Stock or any securities convertible into or exercisable or exchangeable for any shares of Common Stock, or enter into any swap, hedge or other similar agreement that transfers, in whole or in part, the economic risk of ownership of any shares of Common Stock. The Company expects to use any proceeds it receives under the Purchase Agreement for working capital and general corporate purposes.

The foregoing description of the Purchase Agreement does not purport to be complete and is qualified in its entirety by reference to the copy of the Purchase Agreement, which is filed as Exhibit 10.1 to this Current Report on Form 8-K and incorporated herein by reference.

The representations, warranties and covenants contained in the Purchase Agreement were made solely for the benefit of the parties to the Purchase Agreement, and may be subject to limitations agreed upon by the contracting parties. Accordingly, the Purchase Agreement is incorporated herein by reference only to provide investors with information regarding the terms of the Purchase Agreement and not to provide investors with any other factual information regarding the Company or its business, and should be read in conjunction with the disclosures in the Company’s periodic reports and other filings with the SEC.

A copy of the opinion of Paul Hastings LLP, counsel to the Company, relating to the validity of the shares of Common Stock to be issued in the Offering and the CSPA Offering is filed with this Current Report on Form 8-K as Exhibit 5.1.

Ribon Therapeutics Presents Preclinical Data from its PARP7 and PARP14 Programs at AACR Virtual Meeting I

On April 27, 2020 Ribon Therapeutics, a clinical-stage oncology company developing first-in-class therapeutics targeting stress response pathways, reported new preclinical data to be presented at the American Association of Cancer Research (AACR) (Free AACR Whitepaper) Virtual Annual Meeting I. RBN-2397, a first-in-class PARP7 inhibitor, achieves complete tumor regressions in preclinical cancer models (Press release, Ribon Therapeutics, APR 27, 2020, View Source [SID1234556633]). RBN-2397 is Ribon’s lead program and is currently being evaluated in a Phase 1 clinical trial in advanced-stage solid tumors. In addition, in vitro data illustrate the immune-suppressive role PARP14 plays in the tumor microenvironment, suggesting PARP14 targeting could generate an anti-cancer inflammatory response similar to that seen using checkpoint inhibition.

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"The striking tumor regressions we observed in cancer models after dosing with single agent RBN-2397 is what encouraged us to move the program into the clinic so quickly and we look forward to sharing our Phase 1 data when it becomes available," said Kevin Kuntz, Ph.D., Senior Vice President of Molecular Discovery, Ribon Therapeutics. "These data continue to validate our strategy of targeting novel enzyme pathways, starting with the monoPARPs, where there are multiple targets that support tumor growth and immune suppression that can be inhibited therapeutically."

"Our data using primary cell and innovative human cancer models with a novel PARP14 inhibitor support the potential of PARP14 as a therapeutic target. We’ve clearly demonstrated the role of PARP14 in cancer immune suppression and that inhibiting it has the potential to yield responses on par with checkpoint inhibitors," said Heike Keilhack, Ph.D., Senior Vice President of Biological Sciences, Ribon Therapeutics. "Together with the RBN-2397 data, these findings further demonstrate the potential of our platform for both novel target discovery and validation, as well as clinical translation."

Abstract title: RBN-2397 – A First-in-Class PARP7 Inhibitor Targeting a Newly Discovered Cancer Vulnerability in Stress-Signaling Pathways (abstract ID: DDT02-01)
Oral Session: New Drugs on the Horizon – Part 2
Date: Tuesday, April 28, 2020
Time: 10:50 a.m. EDT

Data summary:
The company is presenting an overview of the discovery and preclinical testing of RBN-2397, a first-in-class PARP7 inhibitor targeting a novel cancer vulnerability. PARP7 acts as a brake on cytosolic nucleic acid sensing and the Type I interferon response in tumor cells. Inhibition of PARP7 by RBN-2397 restores Type I IFN signaling as demonstrated by the induction of STAT1 phosphorylation and upregulation of genes enriched for Type I IFN signaling in NCI-H1373 lung cancer cells. Oral dosing of RBN-2397 results in complete tumor regression in a NCI-H1373 lung cancer xenograft model and induces complete tumor regressions with tumor-specific adaptive immune memory in an immunocompetent cancer model. The therapeutic effect of RBN-2397 was shown to be dependent on tumor-derived Type I IFN signaling.

RBN-2397 is currently being studied in a Phase 1 multicenter clinical trial. Additional information on this clinical trial can be found on www.ClinicalTrials.gov (Study Identifier Number – NCT04053673).

Abstract title: RBN012759 – A Potent and Selective PARP14 Inhibitor Decreases Pro-tumor Macrophage Function and Elicits Inflammatory Responses in Tumor Explants (abstract ID: 1038)
Oral Session: Advances in Drug Design and Discovery
Date: Monday, April 27, 2020
Time: 12:20 p.m. EDT

Data summary:
PARP14 helps cancer cells survive and dampens immune responses in two ways: by promoting pro-tumor IL-4 driven gene expression and by downregulating IFN-γ signaling pathways in tumor associated immune cells such as macrophages. In a preclinical setting, Ribon describes the potential of PARP14 inhibition, evaluating RBN012759, the first potent and highly selective inhibitor of PARP14. Ribon demonstrated that RBN012759 effectively binds to and inhibits PARP14, and PARP14 inhibition with RBN012759 reversed IL-4 driven gene expression in macrophages. Treatment of primary tumor cultures with RBN012759 induces an inflammatory response similar to that seen using an anti-PD1/anti-CTLA4 checkpoint inhibitor combination.

NeuBase Therapeutics Announces Proposed Public Offering of Common Stock

On April 27, 2020 NeuBase Therapeutics, Inc. (Nasdaq: NBSE), a preclinical-stage biotechnology company focused on developing next generation therapies to treat rare genetic diseases caused by mutant genes, reported that it has commenced an underwritten public offering of shares of common stock (Press release, NeuBase Therapeutics, APR 27, 2020, View Source [SID1234556632]). The offering is subject to market and other conditions, and there can be no assurance as to whether or when the offering may be completed or as to the actual size or terms of the offering. In addition, the Company intends to grant the underwriters a 30-day option to purchase up to an additional 15% of the shares of common stock sold in the public offering on the same terms and conditions. All of the shares of common stock in the offering will be sold by NeuBase.

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Oppenheimer & Co. and BTIG are acting as the joint book-running managers for the offering, and National Securities Corporation, a wholly-owned subsidiary of National Holdings, Inc. (Nasdaq: NHLD) is acting as co-manager.

NeuBase intends to use the net proceeds from this offering for working capital and general corporate purposes and to advance the development of its product candidates and expand its pipeline.

The securities described above will be offered by NeuBase pursuant to an effective "shelf" registration statement on Form S-3 (File No. 333-220487) previously filed with the Securities and Exchange Commission (the "SEC") on September 15, 2017 and declared effective by the SEC on September 27, 2017. The securities may be offered only by means of a prospectus. A preliminary prospectus supplement and the accompanying prospectus relating to and describing the offering will be filed with the SEC. Electronic copies of the preliminary prospectus supplement and the accompanying prospectus may be obtained by visiting the SEC’s website at www.sec.gov or by contacting Oppenheimer & Co. Inc., Attention: Syndicate Prospectus Department, 85 Broad Street, 26th Floor, New York, NY 10004, by telephone at (212) 667-8055 or by e-mail at [email protected], or BTIG, LLC, Attention: Equity Capital Markets, 65 East 55th Street, New York, NY 10022, by telephone at (212) 593-7555 or by e-mail at [email protected].

This press release does not constitute an offer to sell or the solicitation of an offer to buy, nor shall there be any sale of these securities in any state or jurisdiction in which such offer, solicitation or sale would be unlawful prior to the registration or qualification under the securities laws of any such state or jurisdiction.