Agenus to Report First Quarter 2020 Financial Results on May 7, 2020 and Host Conference Call and Webcast

On April 28, 2020 Agenus Inc. (NASDAQ: AGEN), an immuno-oncology company with an extensive pipeline of agents designed to activate immune response to cancers, reported that it will release its first quarter 2020 financial results before the market opens on Thursday, May 7, 2020 (Press release, Agenus, APR 28, 2020, View Source [SID1234556683]). Agenus executives will host a conference call and webcast at 8:30 a.m. ET the same day to discuss the results and provide a business update.

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To access the live call, dial 1-844-492-3727 (U.S.) or 1-412-317-5118 (International) and ask to be joined into the Agenus call. The call will also be webcast and will be accessible from the Company’s website at View Source or with this link View Source

A replay will be available on the Company’s website approximately one hour after the call and will remain available until July 7, 2020.

Paul Jenkins appointed Interim CEO of Cellesce to accelerate deployment of Company strategy

On April 28, 2020 Cellesce’s Board of Directors reported the appointment of Paul Jenkins as Interim CEO as from 28th April, 2020 (Press release, Cellesce, APR 28, 2020, View Source [SID1234556681]). Paul takes over as CEO from Mark Treherne, who has been CEO since May 2018, and will now focus on his other existing directorships.

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John Allbrook (Non-Executive Chairman of Cellesce) said, "On behalf of the Board I would like to thank Mark for his all his effort and accomplishments over the last 2 years, which have seen the Company make good progress. Under Mark’s stewardship the Company has taken significant steps forward in the development and deployment of its core Organoid Bioprocessing technology, partially funded by a series of successful grant applications. At the same time, the Company has started to gain commercial traction and realised strong revenue growth. I am delighted to welcome Paul Jenkins to Cellesce. These are extraordinary times and the Covid-19 pandemic is presenting all businesses with a unique set of challenges. I am confident with Paul at the helm that Cellesce will rise to these challenges and continue to build on the excellent foundations already in-place."

"Paul is a seasoned business development and senior management executive in Life Sciences. He has amassed a wealth of deal-making and investment experience across a variety of therapeutic areas. Paul’s previous roles include VP Business Development at Catalent, CEO at Adjuvantix, and VP Business Development at West Pharmaceutical Services. Paul is also a strategic advisor to Yorkshire Cancer Research."

Cellesce has developed a new patented bioprocessing technology for the growth and expansion of Patient-Derived Organoids. Organoids are 3-D cell structures with organ-like characteristics grown from adult stem cells. The Company is commercialising its platform, which is a powerful new enabling technology in early-stage drug discovery for multiple types of cancer.

NETRIS Pharma welcomes its new CMO

On April 28, 2020 NETRIS Pharma reported the arrival of Frédéric Le Bras, MD; as the new company Chief Medical Officer (Press release, Netris Pharma, APR 28, 2020, View Source [SID1234556680]). Graduated from René Descartes University in Paris, Frédéric obtained his oncology degree from the Gustave Roussy Institute and mainly worked in pharmaceutical industries in medical affairs, in oncology, rare diseases and immunology, both in France and in Europe.

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"We are very excited to welcome Frederic at NETRIS Pharma" comments Patrick Mehlen, CEO. "Frédéric has a very large experience in the pharmaceutical industry to conduct clinical trial. His timely venue will be instrumental especially when considering the upcoming combination trials that will soon start with our lead asset NP137".

After 29 years spent in oncology and in specialty care in big pharma, Frédéric is very enthusiastic to join NETRIS Pharma: "Not only the great hope of developing a first-in-class compound bringing new hopes in cancer is an exciting challenge but bringing my expertise to a very scientific and dynamic French human-size clinical stage company in Oncology is definitively a new personal project " says Frédéric, adding that "Oncology is like a marathon: you have to start running as fast as you can without forgetting the long way you still have to run."

Aeglea BioTherapeutics Announces Pricing of $120 Million Public Offering

On April 28, 2020 Aeglea BioTherapeutics, Inc. (Nasdaq:AGLE), a clinical-stage biotechnology company developing next-generation human enzyme therapeutics as disruptive solutions for rare and other high-burden diseases, reported the pricing of an underwritten public offering of 11,652,830 shares of its common stock at a price to the public of $4.75 per share (Press release, Aeglea BioTherapeutics, APR 28, 2020, View Source [SID1234556679]). In addition, and in lieu of common stock, Aeglea is offering to certain investors pre-funded warrants to purchase up to an aggregate of 13,610,328 shares of common stock at a purchase price of $4.7499 per pre-funded warrant, which represents the per share public offering price for the common stock less the $0.0001 per share exercise price for each such pre-funded warrant. The aggregate gross proceeds from this offering are expected to be approximately $120 million, before deducting underwriting discounts and commissions and estimated offering expenses payable by Aeglea. The offering is expected to close on or about April 30, 2020, subject to customary closing conditions. Aeglea has also granted the underwriters a 30-day option to purchase up to an additional 3,789,473 shares of common stock in connection with the public offering. All of the securities are being offered by Aeglea.

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J.P. Morgan Securities LLC, Evercore Group L.L.C. and Piper Sandler & Co. are acting as joint book-running managers in the offering. JonesTrading Institutional Services LLC and Needham & Company, LLC are acting as co-managers.

Aeglea intends to use the net proceeds from the offering, together with its existing cash resources, to advance the clinical development of pegzilarginase through its Phase 3 PEACE trial and BLA submission, advance its Phase 1/2 clinical trial and prepare for a potential Phase 3 trial of ACN00177 for Homocystinuria, and the remainder to fund continued research and development, manufacturing, commercialization infrastructure and for working capital and general corporate purposes.

The securities described above are being offered by Aeglea pursuant to a registration statement on Form S-3 previously filed and declared effective by the Securities and Exchange Commission (SEC). The offering is being made only by means of the written prospectus and prospectus supplement that form a part of the registration statement. A preliminary prospectus supplement and accompanying base prospectus relating to and describing the terms of the offering have been filed with the SEC and are available on the SEC’s website at www.sec.gov. Copies of the preliminary prospectus supplement and accompanying base prospectus, and when available, the final prospectus supplement and accompanying base prospectus may also be obtained from J.P. Morgan Securities LLC, Attention: Broadridge Financial Solutions, 1155 Long Island Avenue, Edgewood, NY 11717, by telephone at (866) 803-9204 or by email at [email protected]; Evercore Group L.L.C., Attention: Equity Capital Markets, 55 East 52nd Street, 36th Floor, New York, NY 10055, by telephone at (888) 474-0200, or by e-mail at: [email protected]; or Piper Sandler & Co., 800 Nicollet Mall, J12S03, Minneapolis, Minnesota 55402, Attention: Prospectus Department, by telephone at (800) 747-3924 or by email at [email protected].

This press release shall not constitute an offer to sell or the solicitation of an offer to buy any securities of Aeglea, nor shall there be any sale of these securities in any state or jurisdiction in which such offer, solicitation or sale would be unlawful prior to registration or qualification under the securities laws of any such state or jurisdiction.

Constellation Pharmaceuticals to Host Conference Call to Discuss First Quarter 2020 Results

On April 28, 2020 Constellation Pharmaceuticals, Inc., a clinical-stage biopharmaceutical company using its expertise in epigenetics to discover and develop novel therapeutics, reported that it will host a conference call at 8:00 AM EDT on May 6, 2020, to discuss its first quarter 2020 results and progress in its clinical programs (Press release, Constellation Pharmaceuticals, APR 28, 2020, http://ir.constellationpharma.com/news-releases/news-release-details/constellation-pharmaceuticals-host-conference-call-discuss-first [SID1234556678]). The event will be webcast live and can be accessed on the Investor Relations section of Constellation’s website at View Source To participate in the live question-and-answer session, please dial (877) 473-2077 (domestic) or (661) 378-9662 (international) and refer to conference ID 4372778.

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