On March 25, 2020 LIDDS AB (publ) reported preclinical studies using a TLR9 agonist formulated with NanoZolid (NZ-TLR9) showing that a single NZ-TLR9 injection is reducing tumor growth and improves the survival rate (Press release, Lidds, MAR 25, 2020, View Source [SID1234555853]). The in vivo efficacy is as good as with repeated injections of the standard TLR9 agonist. The pharmacokinetic analysis of treated tumors has confirmed the depot function of NZ-TLR9.

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Clinical data have shown that intratumoral delivery of TLR9 agonists can effectively treat solid cancers. The NanoZolid technology can provide sustained intratumoral release of the injected TLR9 agonist, minimize the need for repeated injections, and allow for a safer treatment of deep-lying tumors. LIDDS preclinical trials in a syngeneic mouse model where LIDDS NZ-TLR9 was intratumorally injected with the NanoZolid technology shows that the antitumoral immune responses were enhanced as well as showing strong antitumoral efficacy data. Importantly, NZ-TLR9 injection is similar in antitumoral efficacy as repeated injections with a standard non-formulated TLR9 agonist.

-TLR9 is one of the most promising immunotherapy targets with a great potential both as monotherapy and in combination with other therapies such as checkpoint inhibitors. The NanoZolid technology addresses key issues in developing TLR agonists as repeated intratumoral injections are needed using standard formulations, said Monica Wallter, CEO of LIDDS.

A preclinical programme is ongoing to further deepen the data obtained so far and LIDDS is preparing for a phase I clinical trial using NanoZolid combined with a TLR9 agonist. The first human study is planned to start in 2021.

To increase antitumoral efficacy and avoid severe systemic side effects, TLR9 agonists are predominantly given as intratumoral injections. However, the need for repeated intratumoral injections when using standard formulated TLR9 agonists poses a risk for the patients and increases the costs for the healthcare systems. The NanoZolid technology having a longer and controlled drug substance release is suitable for a TLR9 agonist treatment, enabling a potential reduction in number of injections and patient compliance.

-I’m really proud of the LIDDS team that successfully have developed a NanoZolid controlled-release formulation of a TLR9 agonist. There is significant commercial potential in this area of research and drug development and the market for TLR agonists is expected to be worth hundreds of millions of dollars over the coming years, commented Monica Wallter.

On March 25, 2020,Thermo Fisher Scientific Inc. (the "Company") reported that it has issued $1,100,000,000 aggregate principal amount of 4.133% Senior Notes due 2025 (the "2025 Notes") and $1,100,000,000 aggregate principal amount of 4.497% Senior Notes due 2030 (the "2030 Notes" and, together with the 2025 Notes, the "Notes") in a public offering (the "Offering") pursuant to a registration statement on Form S-3 (File No. 333-229951) and a preliminary prospectus supplement and prospectus supplement related to the offering of the Notes, each as previously filed with the Securities and Exchange Commission (the "SEC") (Filing, 8-K, Thermo Fisher Scientific, MAR 25, 2020, View Source [SID1234555849]).

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The Notes were issued under an indenture, dated as of November 20, 2009 (the "Base Indenture"), and the Twentieth Supplemental Indenture, dated as of March 25, 2020 (the "Supplemental Indenture" and, together with the Base Indenture, the "Indenture"), between the Company, as issuer, and The Bank of New York Mellon Trust Company, N.A., as trustee. The sale of the Notes was made pursuant to the terms of an Underwriting Agreement, which the Company entered into on March 23, 2020 (the "Underwriting Agreement"), with J.P. Morgan Securities LLC, Morgan Stanley & Co. LLC, BofA Securities, Inc., Deutsche Bank Securities Inc. and Mizuho Securities USA LLC, as representatives of the several underwriters named in Schedule A to the Underwriting Agreement.

The 2025 Notes will mature on March 25, 2025, and the 2030 Notes will mature on March 25, 2030. Interest on the Notes will be paid semi-annually in arrears on March 25 and September 25 each year, commencing on September 25, 2020.

Prior to February 25, 2025 in the case of the 2025 Notes (one month prior to their maturity) and December 25, 2029 in the case of the 2030 Notes (three months prior to their maturity) (each, a "Par Call Date"), the Company may redeem each series of Notes, in whole at any time or in part from time to time, at a redemption price equal to the greater of (1) 100% of the principal amount of the Notes of such series to be redeemed and (2) the sum of the present values of the remaining scheduled payments of principal and interest in respect of the Notes of such series being redeemed (not including any portion of the payments of interest accrued but unpaid as of the date of redemption and assuming that such Notes to be redeemed matured on the Par Call Date), discounted to the date of redemption on a semi-annual basis (assuming a 360-day year of twelve 30-day months), at the Treasury Rate (as defined in the Indenture) plus, in each case, 50 basis points, plus, in each case, accrued and unpaid interest on the Notes of such series being redeemed, if any, to, but excluding, the date of redemption.

In addition, on and after the applicable Par Call Date, the Company may redeem some or all of the Notes at a redemption price equal to 100% of the principal amount of the Notes to be redeemed, plus accrued and unpaid interest, if any, to, but excluding the date of redemption.

Upon the occurrence of a change of control (as defined in the Indenture) of the Company and a contemporaneous downgrade of the Notes below an investment grade rating by at least two of Moody’s Investors Service, Inc., S&P Global Ratings, a division of S&P Global, Inc., and Fitch Ratings, Limited, the Company will, in certain circumstances, be required to make an offer to purchase the Notes at a price equal to 101% of the principal amount of the Notes, plus any accrued and unpaid interest to, but excluding, the date of repurchase.

The Notes are general unsecured obligations of the Company. The Notes rank equally in right of payment with existing and any future unsecured and unsubordinated indebtedness of the Company and rank senior in right of payment to any existing and future indebtedness of the Company that is subordinated to the Notes. The Notes are also effectively subordinated to any existing and future secured indebtedness of the Company to the extent of the assets securing such indebtedness, and are structurally subordinated to all existing and any future indebtedness and any other liabilities of its subsidiaries.

The Indenture contains limited affirmative and negative covenants of the Company. The negative covenants restrict the ability of the Company and its subsidiaries to incur debt secured by liens on Principal Properties (as defined in the Indenture) or on shares of stock of the Company’s Principal Subsidiaries (as defined in the Indenture) and engage in sale and lease-back transactions with respect to any Principal Property. The Indenture also limits the ability of the Company to merge or consolidate or sell all or substantially all of its assets.

Upon the occurrence of an event of default under the Indenture, which includes payment defaults, defaults in the performance of affirmative and negative covenants, bankruptcy and insolvency related defaults and failure to pay certain indebtedness, the obligations of the Company under the Notes may be accelerated, in which case the entire principal amount of the Notes would be immediately due and payable.

The Company expects that the net proceeds from the Offering will be approximately $2.18 billion, after deducting the underwriting discount and estimated offering expenses. The Company intends to use the net proceeds of the offerings (together with cash on hand) to pay a portion of the consideration for the previously announced acquisition of QIAGEN N.V., a public limited liability company organized under the laws of The Netherlands ("QIAGEN"), including the repayment of indebtedness of QIAGEN, and for general corporate purposes.

On March 25, 2020 ArcherDX, Inc., reported that its ArcherMET companion diagnostic (CDx) has been approved by the Japanese Ministry of Health, Labour and Welfare (MHLW) and the Pharmaceutical Medical Devices Agency (PMDA) to detect MET exon 14 (METex14) skipping alterations in tissue (RNA) and liquid biopsy (ctDNA) from patients with advanced non-small cell lung cancer (NSCLC) for consideration for treatment with Merck KGaA, Darmstadt, Germany’s oral MET inhibitor, TEPMETKO* (tepotinib) (Press release, ArcherDX, MAR 25, 2020, https://www.prnewswire.com/news-releases/archerdx-receives-approval-for-archermet-companion-diagnostic-for-tepmetko-tepotinib-in-advanced-non-small-cell-lung-cancer-in-japan-301029535.html [SID1234555838]). ArcherMET is the first and only CDx to be approved for the detection of MET gene alterations and it allows for testing of blood and tissue samples. TEPMETKO is the first approved MET inhibitor in Japan, and is indicated for the treatment of unresectable, advanced or recurrent non-small cell lung cancer with METex14 skipping alterations. TEPMETKO is administered orally once daily. Please see recent news about TEPMETKO here.

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Merck KGaA, Darmstadt, Germany launched a strategic partnership with ArcherDX in 2018 to develop a CDx featuring both liquid and tissue biopsy capabilities, including a program to identify METex14 skipping alterations among patients with advanced NSCLC.

"We’re delighted that the Japan approval of ArcherMET as a companion diagnostic for TEPMETKO means NSCLC patients will have access to Merck KGaA, Darmstadt, Germany’s targeted therapy with demonstrated efficacy," said Jason Myers, Ph.D., Chief Executive Officer and co-founder, ArcherDX. "This approval is the most recent highlight from our ongoing partnership with Merck KGaA, Darmstadt, Germany, and demonstrates our ability to deliver highly accurate and precise companion diagnostics that enable our global partners to accelerate access to therapies for patients in need and democratize personalized medicine."

"With the approval of TEPMETKO and its companion diagnostic, ArcherMET in Japan, NSCLC patients harboring MET exon 14 skipping alterations can now be identified and treated with a targeted approach and precision that was not previously possible," said Zhen Su, M.D., MBA, Senior Vice President & Head of Global Franchise Oncology, Merck KGaA, Darmstadt, Germany. "We are excited that through our partnership with ArcherDX, we are able to address this unmet medical need with a precision approach and deliver important progress for patients living with this aggressive form of lung cancer."

Lung cancer is one of the most common types of cancer worldwide, with approximately 2 million cases diagnosed in 2018.i It is also the second most common type of cancer in Japan. Alterations of the MET signaling pathway, such as METex14 skipping alterations, are found in various cancer types, including 3% to 5% of NSCLC cases, and correlate with aggressive tumor behavior and poor clinical prognosis.ii,iii,iv

*The brand name TEPMETKO is not approved for use outside of Japan.

On March 25, 2020 Cannabics Pharmaceuticals Inc. (OTCQB: CNBX), a leader in personalized cannabinoid medicine focused on cancer and its side effects, reported that its R&D team in Israel studies the combinatorial effects of purified cannabinoids and has recently revealed complex relations between cannabinoid compounds, some of which bare synergistic effects and some antagonistic effects on the viability of gastrointestinal cancer cells (Press release, Cannabics Pharmaceuticals, MAR 25, 2020, View Source [SID1234555837]).

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A heat map of purified cannabinoid combinations showing high synergistic effect in killing gastrointestinal cancer cells only in combinations CB5+CB2. Names of cannabinoids are not present due to IP restrictions.
A heat map of purified cannabinoid combinations showing high synergistic effect in killing gastrointestinal cancer cells only in combinations CB5+CB2. Names of cannabinoids are not present due to IP restrictions.
Natural cannabinoid extracts have been shown to have an entourage effect in various studies in different disease models and clinical studies. The overall view is that the entourage effect leads to better outcomes and purified cannabinoids are more toxic and less effective. However, the underlying combinatorial map of cannabinoids and their effects on cancer cell death remains undiscovered.

Cannabics’ R&D team leverages its High Throughput Screening (HTS) platform to screen the necrotic effects of combinations of purified cannabinoids and builds a matrix to create proprietary new formulations. In this ongoing research on human gastrointestinal cancer cells, purified cannabinoids and their combinations are screened for antitumor effects. Up to date, most of the combinations reveal antagonistic effects and only few show synergisms.

In figure 1, a heat map of purified cannabinoid combinations shows high synergistic effect in killing gastrointestinal cancer cells only in combinations CB5+CB2. Names of cannabinoids are not present due to IP restrictions.

Dr. Eyal Ballan, CTO and Co-Founder, commented, "We examine the efficacy of botanical extracts purified compounds and combinations in order to better understand the potential products under the different regulatory regimes. Our results lead us to new formulations and targets towards clinical validation."

On March 25, 2020 Biocept, Inc. (NASDAQ: BIOC), a leading commercial provider of liquid biopsy tests designed to provide physicians with clinically actionable information to improve the outcomes of cancer patients, reports financial results for the three and 12 months ended December 31, 2019, and provides an update on its business progress (Press release, Biocept, MAR 25, 2020, View Source [SID1234555836]).

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"I’m pleased to report our sixth consecutive quarter of growth with fourth quarter revenues reaching a record $1.8 million, more than double the prior year’s quarterly revenues," said Michael Nall, President and CEO of Biocept. "Our growth for the quarter was driven by year-over-year increases of 46% in commercial test volume and 34% in average reimbursement per patient, predominantly due to reporting on more tests per accession ordered by referring doctors. While growing revenues, we also benefitted from operating efficiencies, including automation initiatives in our CLIA-certified laboratory. These efficiencies combined with higher sample volume moved us significantly closer to positive gross margin. We have more actions to complete the automation of our lab and we are pleased with the contribution from these efforts so far.

"Revenue for the full year 2019 increased 70% over the prior year," said Mr. Nall. "A key growth driver throughout 2019 was our decision to focus on prostate cancer, including committing more commercial resources to urologists and urology practices and introducing additional prognostic and predictive biomarker tests. As the year progressed, we were encouraged that more urologists were using more biomarkers per test for more of their patients.

"I’m exceptionally proud of our strong operational performance throughout 2019 and into 2020. Among notable accomplishments, we launched the first-and-only liquid biopsy test to evaluate cerebrospinal fluid as well as NGS test panels for lung and breast cancer. We also added a new revenue stream from sales of our Target Selector research-use only (RUO) kits, further expanded our intellectual property portfolio with new U.S. and foreign patents, and presented compelling data further validating our technology at multiple scientific conferences and in peer-reviewed journals," he added. "So far this year, we have raised net proceeds of $17.5 million from two equity offerings and warrant exercises, positioning us for continued execution on our growth strategy."

2019 and Recent Highlights

Commercial Launches

Announced the availability of Target Selector assays to evaluate cerebrospinal fluid (CSF) for the presence of circulating tumor cells (CTCs) and biomarkers, which may be indicators of brain metastases. Of patients diagnosed with breast and lung cancer, 30% and 36%, respectively, will develop brain metastases. The validations study for the CSF assay was conducted in collaboration with Providence St. Joseph Health, Southern California, and its wholly owned affiliates Providence St. John’s Health Center and John Wayne Cancer Institute.
Launched Target Selector NGS Lung Panel and Target Selector NGS Breast Panel, the Company’s first two multi-gene liquid biopsy panels, differentiating Biocept as the only commercial liquid biopsy provider of single-biomarker testing, tumor-specific panels and CTC analysis. The NGS Panels run on Thermo Fisher Scientific’s Ion Torrent NGS platform and are being marketed to physicians and researchers for the detection and monitoring of actionable biomarkers associated with these tumor-specific cancers.
Launched Target Selector pan-TRK assay for the detection of TRK proteins, which are actionable biomarkers that can be used to qualify patients for treatment with TRK inhibitor therapies. The pan-TRK assay, which utilizes Biocept’s proprietary CTC platform to screen for TRK gene alternations, is a unique liquid biopsy offering.
Launched expanded pathology partnership service, EmpowerTC, with additional prognostic and predictive biomarker tests to enable urology and uropathology practices to perform liquid biopsy testing and interpret results generated in Biocept’s CLIA-certified laboratory.
Announced the availability of RUO kits, which enable molecular laboratories around the world to utilize Target Selector circulating tumor DNA (ctDNA) assays to perform liquid biopsy testing. Also announced an agreement with Agiomix FZ-LLC, a provider of genomics sample and bioinformatics services for research and clinical applications, to validate and purchase Biocept’s Target Selector RUO kits for use in its laboratory.
Commercial Agreements

Announced an agreement with Beacon Laboratory Benefit Solutions designating Biocept as a BeaconLBS Lab-of-Choice, increasing patient access to Biocept’ liquid biopsy testing platforms. Beacon Laboratory is a nationally recognized provider of laboratory benefit management technology solutions to U.S.-based health and managed care companies.
Signed an agreement with a large California-based independent physician association (IPA) to provide Biocept’s Target Selector liquid biopsy testing services to physicians and patients in their network.
Regulatory Approval

Obtained CE IVD Marks for the CEE-Sure Blood Collection Tube and the CEE-Sure Sample Collection Shipping Kit in Europe. These CE Marks confirm that Biocept’s CEE-Sure products, which are specifically designed to collect and transport blood and other liquid biopsy specimens, meet the requirements of the European In-Vitro Diagnostic Devices Directive. These clearances allow Biocept to commercialize its tubes and collection/shipping kits throughout the European Union and other CE Mark geographies.
Industry Conference Presentations

Presented six posters at the 2019 Association for Molecular Pathology (AMP) Annual Meeting featuring clinical data highlighting Target Selector tests and kits. The content of these posters will be published in a future issue of The Journal of Molecular Diagnostics.
Presented data at the 2019 IASLC World Conference on Lung Cancer highlighting the ability of Biocept’s circulating tumor DNA (ctDNA) assays to consistently detect actionable biomarkers from the blood of patients diagnosed with lung cancer at a mutant allele frequency as low as 0.01%. The poster featured data from more than 1,400 blood samples drawn from patients diagnosed with non-small cell lung cancer, and collected and shipped using the Company’s CEE-Sure Blood Collection Tubes.
Presented a poster at the 2019 American Association for Cancer Research (AACR) (Free AACR Whitepaper) Annual Meeting demonstrating the ability of the Target Selector assay to detect ESR1 mutations with high sensitivity, resulting in inclusion of the test in a clinical trial sponsored by a major pharmaceutical company.
Presented a poster at the 2019 San Antonio Breast Cancer Symposium demonstrating the ability of the Target Selector CTC platform to aid in the monitoring and treatment of breast cancer. Study results demonstrated the platform’s ability to accurately detect, enumerate and interrogate CTCs in a cohort of more than 1,500 patients, representing various clinical and treatment stages of breast cancer.
Peer-reviewed Journal Publications

Announced publication of clinical data in Journal of Clinical Pathology that further validates Biocept’s Target Selector qPCR Assay using "Switch Blocker" technology to identify cancer-related mutations in liquid biopsy samples. Study results showed a very high concordance between Biocept’s liquid biopsy testing and tissue biopsy and best-in-class detection of alterations down to a single mutant copy in both analytical and clinical settings.
Announced publication of case studies in Clinics in Oncology demonstrating the clinical utility of Target Selector testing in the management of patients diagnosed with advanced non-small cell lung cancer. In each case study, Biocept’s liquid biopsy testing detected activating EGFR mutations where tissue biopsy was inadequate, and targeted EGFR-directed therapy was subsequently administered.
Announced publication of an article in PLOS ONE featuring analytical validation results demonstrating the ultra-sensitive detection of Target Selector testing for EGFR, BRAF and KRAS mutations in plasma ctDNA. These tests can be performed in the Company’s CLIA laboratory with a commercial turnaround time of only three to four days.
Intellectual Property

Awarded U.S., Canadian and European patents covering antibody and microchannel technology and enhanced detection of cancer cells. These new patents further expand Biocept’s intellectual property estate for capturing and detecting rare cells of interest, including CTCs, to aid in the management of patients with cancer.
Granted a South Korean patent covering the Target Selector oncogene mutation enrichment and detection platform for proprietary Switch-Blocker technology that is core to Target Selector assays for molecular analysis using real-time PCR, Sanger sequencing and next-generation sequencing.
Awarded a patent in China covering methods and devices for the capture of rare cells of interest, including CTCs, that are shed into the bloodstream by solid tumors in which an antibody or mixture of antibodies and a microchannel are used for cell capture, detection and analysis. This patent covers the use of any biological sample type of interest.
Obtained a patent in Japan covering the use of microchannels for the capture and detection of any target of interest, including proteins and nucleic acids, as well as the capture of cancer or other rare cells that can be used for molecular analysis in blood and other biological fluids.
Awarded a patent in the U.S. covering devices for the detection of cells of interest, including CTCs that are shed into the bloodstream by solid tumors where an antibody, or mixture of antibodies, and any solid surface are used for cell capture, detection and analysis, including any biological sample type, using single antibodies or cocktails of antibodies.
Exited 2019 with 37 issued patents globally for Biocept’s highly sensitive method of detecting cancer biomarkers.
Corporate Developments

Promoted Cory J. Dunn, M.S., M. Ed. to Senior Vice President of Commercial Operations. Ms. Dunn joined Biocept as Vice President of Commercial Operations in October 2018.
Fourth Quarter Financial Results

Revenues for the fourth quarter of 2019 were $1.8 million, a 108% increase from $859,000 for the fourth quarter of 2018. Revenues for the fourth quarter of 2019 included $1.6 million in commercial test revenue, $87,000 in development services test revenue, and $108,000 in revenue for Target Selector RUO kits, which were commercially launched in early 2019, and CEE-Sure blood collection tubes. Revenues for the fourth quarter of 2018 included $820,000 in commercial test revenues and $39,000 in development services test revenues.

Biocept accessioned 1,159 commercial samples during the fourth quarter of 2019, a 46% increase from the 795 commercial samples accessioned during the fourth quarter of 2018. The Company accessioned 1,278 billable samples during the fourth quarter of 2019, a 36% increase from 938 billable samples during the fourth quarter of 2018.

Cost of revenues for the fourth quarter of 2019 was $2.9 million, compared with $2.4 million for the fourth quarter of 2018. Cost of revenues increased 18% while billable accession volume increased by 36% as the Company continued to leverage its fixed costs.

Research and development (R&D) expenses for the fourth quarter of 2019 were $1.2 million, compared with $1.3 million for the fourth quarter of 2018, with the decrease primarily due to lower allocated cost of laboratory associated activities. General and administrative (G&A) expenses for the fourth quarter of 2019 were $1.9 million, compared with $1.6 million for the fourth quarter of 2018, with the increase due mainly to a reclass of customer service and related expenses from Sales & Marketing to G&A. Sales and marketing (S&M) expenses for the fourth quarter of 2019 were $1.5 million, compared with $1.4 million for the fourth quarter of 2018, with the increase primarily attributed to commissions paid for higher volume and revenue.

The fourth quarter of 2019 included a non-cash deemed dividend of $22,000 for the repricing of adjustable warrants. There was no comparable charge in the fourth quarter of 2018.

The net loss attributable to common shareholders for the fourth quarter of 2019 was $5.7 million, or $0.20 per share on 29.1 million weighted-average shares outstanding. The net loss attributable to common shareholders for the fourth quarter of 2018 was $6.0 million, or $1.43 per share on 4.2 million weighted-average shares outstanding.

Full Year Financial Results

Revenues for 2019 were $5.5 million, a 70% increase from $3.3 million for 2018. Revenues for 2019 included $5.1 million in commercial test revenues, $212,000 in development services test revenues, and $200,000 in revenues for Target Selector RUO kits and CEE-Sure blood collection tubes. Revenues for 2018 included $3.0 million in commercial test revenues and $199,000 in development services test revenues.

Biocept accessioned 4,425 commercial samples during 2019, a 35% increase from the 3,273 commercial samples accessioned during 2018. The Company accessioned 4,976 billable samples during 2019, a 28% increase from 3,896 billable samples during 2018.

Cost of revenues for 2019 was $11.0 million, compared with $10.1 million for 2018. Cost of revenues for 2019 increased 9% while billable accession volume increased by nearly 28%, both compared with 2018.

Total costs and expenses for 2019 were $28.6 million, and included cost of revenues of $11.0 million, R&D expenses of $4.7 million, G&A expenses of $7.0 million and S&M expenses of $5.9 million.

Other expense for 2019 of $2.1 million consisted of non-cash warrant inducement expenses associated with recognizing the fair value of the inducement warrants issued in May 2019 of $1.8 million and $250,000 of interest expense related to equipment finance leases. This compares with other expense for 2018 of $311,000 related to interest expense. Non-cash deemed dividend for the repricing of adjustable warrants for 2019 was of $0.1 million, compared with $0.6 million for 2018.

The net loss attributable to common shareholders for 2019 was $25.3 million, or $1.22 per share on 20.7 million weighted-average shares outstanding. This compares with a net loss attributable to common shareholders for 2018 of $25.2 million, or $9.01 per share on 2.8 million weighted-average shares outstanding. The per-share figures reflect a 1-for-30 reverse split of common stock completed in July 2018.

Biocept reported cash and cash equivalents as of December 31, 2019 of $9.3 million, compared with $3.4 million as of December 31, 2018. The increase includes $25.7 million in net proceeds from equity capital raises conducted in the first and fourth quarters of 2019, and $4.9 million from the exercise of common stock warrants during 2019.

Conference Call and Webcast

Biocept will hold a conference call today at 4:30 p.m. Eastern time to discuss these results and answer questions. The conference call can be accessed by dialing (855) 656-0927 for domestic callers, (855) 669-9657 for Canadian callers or (412) 902-4109 for other international callers. A live webcast of the conference call will be available on the investor relations page of the company’s website at http://ir.biocept.com/events.cfm.

A replay of the call will be available for 48 hours following its conclusion and can be accessed by dialing (877) 344-7529 for domestic callers, (855) 669-9658 for Canadian callers or (412) 317-0088 for other international callers. Please use event passcode 10140336. A replay of the webcast will be available for 90 days.