Bausch Health Publishes Company Update for the 38th Annual J.P. Morgan Healthcare Conference

On January 13, 2020 Bausch Health Companies Inc. (NYSE/TSX: BHC) (the "Company") reported that it has published a brief company update presentation designed to complement remarks that will be provided by management during a fireside chat at 1:30 p.m. PT (4:30 p.m. ET) during the 38th Annual J.P. Morgan Healthcare Conference in San Francisco (Press release, Bausch Health, JAN 13, 2020, View Source [SID1234553131]). The presentation provides an overview of the Company’s recent performance and achievements, including updates on the Company’s 2019 commitments and development programs, and offers insight into future goals and catalysts for 2020 and beyond.

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The presentation is available on the Investor Relations page of the Bausch Health Companies Inc. web site at: View Source A live webcast and audio archive of the fireside chat will also be available on the Investor Relations page of the Company’s web site.

Revolution Medicines Presents Data from its SHP2 and Oncogenic RAS(ON) Programs at 6th AACR-IASLC International Joint Conference

On January 13, 2020 Revolution Medicines, Inc., a clinical-stage oncology company focused on developing targeted therapies to inhibit elusive frontier targets within notorious cancer pathways, reported that preliminary data from the company’s Phase 1 clinical trial (RMC-4630-01) of RMC-4630 were reported in podium and poster presentations at the 6th AACR (Free AACR Whitepaper)-IASLC International Joint Conference: Lung Cancer Translational Science from the Bench to the Clinic being held January 11-14, 2020 in San Diego, CA (Press release, Revolution Medicines, JAN 13, 2020, https://www.prnewswire.com/news-releases/revolution-medicines-presents-data-from-its-shp2-and-oncogenic-rason-programs-at-6th-aacr-iaslc-international-joint-conference-300985342.html [SID1234553129]). In this study RMC-4630 has shown reasonable tolerability and preliminary signs of clinical activity in patients with non-small cell lung cancer (NSCLC) harboring KRAS mutations, particularly KRASG12C.

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RMC-4630, the company’s investigational SHP2 inhibitor, is a potent and orally bioavailable small molecule that is designed to selectively inhibit the activity of SHP2, an upstream cellular protein that plays a key role in modulating cell growth by transmitting signals from receptor tyrosine kinases to RAS. The ongoing Phase 1 monotherapy study is evaluating RMC-4630 for a range of tumor types featuring specific, molecularly-defined oncogenic mutations.

Data from the study were reported in podium and poster presentations entitled, "The SHP2 inhibitor RMC-4630 in patients with KRAS-mutant non-small cell lung cancer: Preliminary evaluation of a first-in-man phase 1 clinical trial." These presentations are available on the company’s website at the following links:

Podium Presentation: http://bit.ly/2tLiHjo

Poster Presentation: http://bit.ly/2R4dafU

In addition to the presentations on RMC-4630, Revolution Medicines also reported preclinical data on its mutant RAS(ON) inhibitors in a poster presentation at the conference. This presentation is available on the company’s website at the following link:

Poster Presentation: http://bit.ly/2FCw3Bu

About RMC-4630 and Sanofi Collaboration

The RMC-4630 program is the focus of an exclusive global research, development and commercialization agreement with Sanofi, under which Revolution Medicines received a $50 million upfront payment, and Sanofi agreed to reimburse Revolution Medicines for substantially all research and all development costs for the joint SHP2 program. Sanofi received an exclusive worldwide license for global commercialization of any approved products targeting SHP2, subject to a U.S. co-promote right for Revolution Medicines. The companies have agreed to enter into a 50/50 profit and loss share arrangement in the U.S., and Revolution Medicines is entitled to receive tiered royalties on annual net sales ranging from high single digit to mid-teen percentages on sales in other markets. Revolution Medicines could also receive more than $500 million in development and regulatory milestone payments.

ViewRay Announces Preliminary Fourth Quarter and Full Year 2019 Results

On January 13, 2020 ViewRay, Inc. (NASDAQ: VRAY) reported preliminary results for the fourth quarter and full fiscal year ended December 31, 2019 (Press release, ViewRay, JAN 13, 2020, View Source [SID1234553128]). The preliminary results have not been audited and are subject to change .

Selected Fourth Quarter and Full Year 2019 Preliminary Results:

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Total revenue of approximately $17 million in the fourth quarter of 2019, primarily from three revenue units including one system upgrade, compared to total revenue of $21 million, primarily from four revenue units including one system upgrade, in the fourth quarter of 2018.
Received four new orders for MRIdian systems totaling approximately $21 million in the fourth quarter of 2019, compared to eight new orders totaling approximately $49 million in the fourth quarter of 2018.
Full year 2019 revenue of approximately $88 million, primarily from 15 revenue units, including two system upgrades, compared to 2018 revenue of approximately $81 million, primarily from 15 revenue units, including two system upgrades.
Total backlog was approximately $227 million as of December 31, 2019.
Cash and cash equivalents were approximately $227 million as of December 31, 2019. Cash burn in the fourth quarter of 2019, excluding the impact of the December 2019 financing, was approximately $3 million.
Chief Commercial Officer Jim Alecxih will be leaving the company effective January 17, 2020. At this time the company does not intend to backfill the Chief Commercial Officer role.
"In 2019 we built significant organizational expertise, made progress on our innovation and clinical pipelines, and fortified our balance sheet," said Scott Drake, President and CEO. "We are now better positioned than ever to improve the treatment paradigm for cancer patients. Today we also announced that Jim Alecxih, our Chief Commercial Officer, will be leaving the company to pursue other opportunities. We thank Jim for his service."

Financial guidance for 2020 will be provided on the company’s fourth quarter earnings conference call later this year.

NuVasive Announces Preliminary Unaudited Fourth Quarter and Full Year 2019 Revenue Results

On January 13, 2020 NuVasive, Inc. (NASDAQ: NUVA), the leader in spine technology innovation, focused on transforming spine surgery with minimally disruptive, procedurally integrated solutions, reported preliminary unaudited revenue results for the fourth quarter and full year 2019 (Press release, NuVasive, JAN 13, 2020, View Source [SID1234553127]).

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Fourth Quarter 2019 Highlights

Revenue of approximately $310 million, increased approximately 8% on both a reported and constant currency basis;
U.S. Spinal Hardware revenue increased approximately 8%;
U.S. Surgical Support revenue increased approximately 3%; and
International revenue increased approximately 14% on a reported and constant currency basis.
Full Year 2019 Highlights

Revenue of approximately $1.17 billion, increased approximately 6% on a reported basis and approximately 7% on a constant currency basis;
U.S. Spinal Hardware revenue increased approximately 7%;
U.S. Surgical Support revenue increased approximately 1%; and
International revenue increased approximately 10% on a reported basis and 12% on a constant currency basis.
NuVasive will report its full financial results for 2019 and provide its financial outlook for 2020 during its earnings announcement planned for late February.

"NuVasive delivered consistent above-market growth in 2019, with growth in the fourth quarter across all business lines," said J. Christopher Barry, chief executive officer of NuVasive. "We made meaningful progress throughout the organization last year, including the launch of differentiated new products and advancing enabling technologies to support our continued leadership in minimally invasive spine surgery."

38th Annual J.P. Morgan Healthcare Conference on Wednesday, Jan. 15, 2020
NuVasive will participate in the 38th Annual J.P. Morgan Healthcare Conference on Wednesday, Jan. 15 at the Westin St. Francis in San Francisco. Mr. Barry will represent the Company in a presentation scheduled for 10:00 a.m. PT/1:00 p.m. ET.

A live webcast of the presentation will be available online from the Investor Relations page of the Company’s website at www.nuvasive.com. A replay of the presentation will remain available on the website for 30 days after the live webcast.

DNAtrix Appoints Jeff Knapp as Chief Executive Officer and to Board of Directors

On January 13, 2020 DNAtrix, a leader in the development of oncolytic viruses for cancer therapy, reported that Jeffrey Knapp has been appointed as Chief Executive Officer and to the Board of Directors (Press release, DNAtrix, JAN 13, 2020, View Source [SID1234553126]). Stephen Dilly has been appointed as Chairman of the Board of Directors.

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"We are pleased to welcome Jeff as Chief Executive Officer of DNAtrix," said Stephen Dilly, MBBS, Ph.D., Chairman of the DNAtrix Board of Directors. "We look forward to benefiting from his deep industry experience as a senior leader in the pharmaceutical industry, who has helped to develop multiple products in the clinic and bring them to market. As we prepare for Phase 3 development and the potential commercialization of our lead program, DNX-2401, Jeff’s knowledge will be invaluable to us as we work to achieve our mission of delivering novel oncolytic virus therapies to patients with some of the most aggressive forms of cancer."

"I am thrilled to be working with DNAtrix at this pivotal time in the company’s growth," said Mr. Knapp. "The data from the Phase 2 trial (CAPTIVE) of DNX-2401 is compelling and it demonstrates the potential of DNX-2401 to transform the standard of care for patients with recurrent glioblastoma. I look forward to working with this impressive team to advance DNAtrix’s pipeline of oncolytic virus candidates through clinical development and to prepare for potential commercialization."

Mr. Knapp joins DNAtrix with over 30 years of experience in the pharmaceutical industry, including 20 in executive management. He has developed and executed strategies supporting clinical development, regulatory approval, and commercial launch of multiple products across a diverse array of therapeutic areas. Mr. Knapp most recently served as Chief Operating Officer at Aimmune Therapeutics where he was responsible for preparing the company’s first asset, AR101, for approval and commercial launch in the United States and Europe as a treatment for children and adolescents with peanut allergies. Previously, Mr. Knapp held several executive and senior management positions in biopharmaceutical companies at similar stages of growth. Mr. Knapp holds a B.A. in Biology with a Minor in Business Administration from Wittenberg University.

Dr. Dilly added, "On behalf of the DNAtrix Board of Directors, I would also like to extend our gratitude to Dr. Frank Tufaro for his leadership over the last several years, particularly for guiding the company through several clinical trials that have brought us to this important point. We are grateful for Dr. Tufaro’s hard work to grow the company and for his commitment to patients."

Dr. Dilly brings over two decades of executive and senior management experience in the biopharmaceutical industry to the DNAtrix Board of Directors. He also serves as Board Chairman of Cognoa, a pediatric behavioral health company, is a Board member of Sangamo Therapeutics and Adjuvance Technologies, and is on the Industry Advisory Board of Longitude Ventures. Previously, Dr. Dilly served as Chief Executive Officer and Board Member of Aimmune Therapeutics, where he currently serves as Special Advisor on Clinical and Regulatory affairs. Earlier in his career, Dr. Dilly served in executive and senior management roles associated with the development and launch of marketed drugs for many therapeutic areas. Dr. Dilly holds an M.B.B.S., the equivalent of an M.D. in the U.S., from the University of London in the U.K. and a Ph.D. in Cardiac Physiology from University of London.