Exicure to Present at Biotech Showcase 2019 on January 8th at 2:30 pm PT

On January 3, 2019 Exicure, Inc. (OTCQB: XCUR), the pioneer in gene regulatory and immunotherapeutic drugs utilizing three-dimensional spherical nucleic acid (SNA) constructs, reported that its CEO, Dr. David Giljohann, will present a corporate update on Tuesday, January 8, 2019 from 2:30 pm to 3:00 pm PT at the Biotech Showcase 2019 (Press release, Exicure, JAN 3, 2019, View Source [SID1234532412]). The presentation will be in the Franciscan A room on the Ballroom level of the Hilton San Francisco Union Square.

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A live audio webcast will be available on the Investors section of Exicure’s website: www.exicuretx.com. The webcast will be archived for approximately 30 days following the event.

UroGen Pharma Appoints Elizabeth (Liz) Barrett as President and Chief Executive Officer

On January 3, 2019 UroGen Pharma Ltd. (Nasdaq:URGN), a clinical-stage biopharmaceutical company developing treatments to address unmet needs in the field of urology, with a focus on uro-oncology, reported the appointment of Elizabeth (Liz) Barrett as President and Chief Executive Officer effective immediately (Press release, UroGen Pharma, JAN 3, 2019, View Source [SID1234532411]). She will also serve on the Company’s Board of Directors. Ms. Barrett, who will be based in New York, replaces Ron Bentsur. Mr. Bentsur will step down from his position at the Company but will continue to serve in an advisory capacity as needed to ensure a smooth transition.

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Ms. Barrett will present at the 37th Annual J.P. Morgan Healthcare Conference on Thursday, January 10, 2019 at 10:30 a.m. Pacific Time. The event will be held in San Francisco at the Westin St. Francis.

Ms. Barrett brings over 30 years of unique experience across oncology, specialty care, surgical franchises, and consumer marketing in multiple geographic regions. Her demonstrated expertise in pharmaceutical development and commercialization of oncology products will be critical as UroGen transforms into a leading commercial-stage entity and delivers potentially paradigm-shifting products to oncology patients in the urological setting.

"Liz has proven to be an exceptional leader with a well-established track record in oncology and the vision and experience to lead UroGen as it prepares for the expected launch of UGN-101, the Company’s first potential product, in 2019," said Arie Belldegrun, M.D., FACS, Chairman of the Board of UroGen. "Through the persistence and dedication of Ron Bentsur and the team, UroGen has become a leader in uro-oncology, and has energized much needed innovation in devastating urologic diseases that are often overlooked. We thank Ron for his commitment to UroGen and are pleased to support him in his future endeavors to focus on innovative early stage life sciences companies."

Ms. Barrett was CEO of Novartis Oncology and a member of the Executive Committee of Novartis. She previously served as Global President of Oncology at Pfizer Inc. At Pfizer, she held numerous leadership positions, including President of Global Innovative Pharma for Europe, President of the Specialty Care Business Unit for North America, and President of United States Oncology. Prior to Pfizer, she was Vice President and General Manager of the Oncology Business Unit at Cephalon Inc. Ms. Barrett also worked at Johnson & Johnson. She started her career at Kraft Foods Group Inc. Ms. Barrett holds a Bachelor of Science from the University of Louisiana and a Master of Business Administration from Saint Joseph’s University.

"I’ve built a career with some of the best companies in the industry and have had the opportunity to be entrepreneurial within each of those positions. This is an opportune time to take that experience and apply it to a smaller biotech company on the cusp of transformation," said Ms. Barrett. "UroGen is well positioned to firmly establish the viability of its RTGel platform as the Company completes its first NDA submission to the FDA and prepares for potential commercialization later this year. I cannot think of a more exciting time to join UroGen and work with its outstanding team as we begin to revolutionize uro-oncology and beyond."

"I’ve had the great honor of leading UroGen through its early stages of development, its initial public offering, completed enrollment of our first pivotal trial, and now, initiation of our first rolling NDA submission," said Ron Bentsur. "I have no doubt that Liz will be a great leader during UroGen’s next stage and will have the experience needed to build on our clinical success and prepare the company for commercialization. I look forward to supporting the Company’s ongoing success."

UroGen recently announced its initiation of the UGN-101 Rolling NDA Submission to the U.S. Food and Drug Administration (FDA). The completed submission is expected in mid-2019, with potential approval anticipated in 2019. The Company plans to present the topline data in January 2019.

A live audio webcast of the J.P. Morgan presentation will be available on the Investors section of UroGen’s website www.urogen.com. A replay of the webcast will be available on the website for approximately 30 days.

Aadi Bioscience Receives Breakthrough Therapy Designation for TARZIFYX™ (ABI-009) in PEComa Indication

On January 3, 2019 Aadi Bioscience, Inc. (Aadi), a clinical stage biopharmaceutical company focused on treating diseases driven by mTOR activation, reported that its drug TARZIFYX (sirolimus albumin-bound nanoparticles for injectable suspension, ABI-009) has received Breakthrough Therapy Designation status from the FDA for the indication of Advanced (metastatic or locally advanced) Malignant PEComa (perivascular epithelioid cell tumor) (Press release, Aadi, JAN 3, 2019, View Source [SID1234532410]). The designation was granted based on data provided to the FDA from Aadi’s ongoing phase 2 registration trial (NCT02494570) in Advanced Malignant PEComa. In October 2018, Aadi also received Fast Track Designation from the FDA for TARZIFYX for the same indication. Aadi received orphan drug designation for TARZIFYX for the treatment of PEComa in December 2017.

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Aadi’s Phase 2 registration trial for Advanced Malignant Perivascular Epithelioid Cell Tumors (AMPECT), a rare form of sarcoma, has completed enrollment. Aadi previously received agreement from the FDA that this open label study in 30 efficacy evaluable patients with a primary endpoint of overall response rate could support the submission of an NDA for approval to treat this rare disease.

"We are extremely pleased with the progress of the AMPECT study and recognition of the high unmet need in this patient population via the Breakthrough Designation. Our small, but dedicated team is gearing up for NDA filing in 2019," said Neil Desai, Ph.D., Founder and Chief Executive Officer of Aadi. "There has been no prior clinical trial in this rare disease and standard chemotherapies used in sarcoma treatment have very limited activity in this patient population."

mTOR inhibition is relevant in a number of disease states and has not been fully exploited in oncology, cardiovascular disease, CNS diseases, mitochondrial disease, diseases of ageing, etc. Due to the unique properties of Aadi’s drug including effective CNS penetration, it is being tested in nine ongoing clinical studies across these indications with encouraging results even outside of oncology in early studies in pulmonary hypertension and surgically refractory epilepsy. Aadi’s ongoing and planned clinical trials include Oncology (pediatric tumors, advanced sarcoma, first-line treatment of advanced colorectal cancer, newly diagnosed and recurrent glioblastoma, advanced neuroendocrine tumors), Cardiovascular indications (pulmonary arterial hypertension), CNS indications (surgically refractory epilepsy) and Mitochondrial disease (Leigh Syndrome).

AbbVie to Host Fourth-Quarter and Full-Year 2018 Earnings Conference Call

On January 3, 2019 AbbVie (NYSE: ABBV), a research-based global biopharmaceutical company, reported that it will announce its fourth-quarter and full-year 2018 financial results on Friday, January 25, 2019 before the market open (Press release, AbbVie, JAN 3, 2019, View Source [SID1234532409]). AbbVie will host a live webcast of the earnings conference call at 8 a.m. Central time (9 a.m. Eastern). It will be accessible through AbbVie’s Investor Relations website investors.abbvie.com. An archived edition of the session will be available later that day.

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Early/Late Stage Pipeline Development - Target Scouting - Clinical Biomarkers - Indication Selection & Expansion - BD&L Contacts - Conference Reports - Combinatorial Drug Settings - Companion Diagnostics - Drug Repositioning - First-in-class Analysis - Competitive Analysis - Deals & Licensing

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Actinium Pharmaceuticals, Inc. to Present at the 2019 Biotech Showcase™ in San Francisco

On January 3, 2019 Actinium Pharmaceuticals, Inc. (NYSE American: ATNM) reported that Sandesh Seth, Actinium’s Chairman and Chief Executive Officer will present at the Biotech Showcase 2019 being held on January 7-9 (Press release, Actinium Pharmaceuticals, JAN 3, 2019, View Source [SID1234532408]). The conference will be held at the Hilton San Francisco Union Square. Details of Actinium’s presentation are as follows:

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Date: Monday, January 7, 2019
Time: 10:00 AM PT
Track: Yosemite A (Ballroom Level)
Venue: Hilton San Francisco Union Square

Members of Actinium’s Executive and Corporate Development teams will be available for 1-on-1 meetings during the conference. Those interested in scheduling a meeting with Actinium may do so by contacting Steve O’Loughlin, Actinium’s Principal Financial Officer via email to [email protected].

Biotech Showcase, produced by Demy-Colton and EBD Group, is an investor and networking conference devoted to providing private and public biotechnology and life sciences companies with an opportunity to present to, and meet with, investors and executives in one place during the course of one of the industry’s largest annual healthcare investor conferences, J.P. Morgan Annual Healthcare Conference.