WuXi AppTec Reports Third-Quarter 2019 Results

On October 30, 2019 WuXi AppTec Co., Ltd. (stock code: 603259.SH / 2359.HK), a company that provides a broad portfolio of R&D and manufacturing services that enable companies in the pharmaceutical, biotech and medical device industries worldwide to advance discoveries and deliver groundbreaking treatments to patients, reported its financial results for the third quarter and nine months ended September 30, 2019 ("Reporting Period") (Press release, WuXi AppTec, OCT 30, 2019, View Source [SID1234550077]).

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This document serves purely as a summary and is not intended to provide a complete representation of the relevant matters. For further information, please refer to the 2019 third quarterly report and relevant announcements published on the websites of the Shanghai Stock Exchange (www.sse.com.cn) and the Stock Exchange of Hong Kong (www.hkexnews.hk), and the designated media for dissemination of the relevant information. Investors are advised to exercise caution and be aware of the investment risks in dealing in the shares of the Company.

All financials disclosed in this press release are prepared based on International Financial Reporting Standards (or "IFRSs").

The 2019 Third-Quarter Report of the Company has not been audited.

Third-Quarter 2019 Financial Highlights

Accelerated revenue growth of 34.7% year-over-year to RMB 3,384 million, which was broad-based across all our business segments.
Gross profit grew 31.5% year-over-year to RMB 1,377 million. Gross profit margin was 40.7%.[3]
EBITDA grew 22.0% Year-Over-Year to RMB 1,155 million.
Adjusted EBITDA grew 51.6% Year-Over-Year to RMB 1,107 million.
Adjusted non-IFRS net profit attributable to owners of the Company grew 50.2% year-over-year to RMB 664 million.
Net profit attributable to owners of the Company grew 7.9% year-over-year to RMB 708 million. Net profit growth rate was slower than revenue growth rate due to RMB 227 million decrease in fair value gain of our investment portfolio from RMB 237 million in the third quarter of 2018 to RMB 10 million in the same period this year.
Adjusted diluted non-IFRS EPS increased by 36.7% versus the same period last year while diluted EPS was down 4.4%.[4]
Year-to-Date 2019 Financial Highlights

Accelerated revenue growth of 34.1% year-over-year to RMB 9,279 million.
Gross profit grew 30.6% year-over-year to RMB 3,660 million. Gross profit margin was 39.5%.[5]
EBITDA grew 7.3% Year-Over-Year to RMB 2,914 million.
Adjusted EBITDA grew 41.0% Year-Over-Year to RMB 3,006 million.
Adjusted non-IFRS net profit attributable to owners of the Company grew 38.0% year-over-year to RMB 1,842 million.
Net profit attributable to owners of the Company was lower 8.5% year-over-year to RMB 1,765 million, due to a RMB 45 million loss from changes in fair value of our investment portfolio for the first nine months of 2019, versus a RMB 669 million gain in the same period last year.
Adjusted diluted non-IFRS EPS increased by 17.7% versus the same period last year while diluted EPS was down 22.5%.[6]
Management Comment

Mr. Edward Hu, Co-CEO of WuXi AppTec, said, "Our growth continued to accelerate for the third quarter of 2019. In addition, we continue to focus on customer development and business conversion with a strategy of following the projects and following the molecules, leveraging synergies across all our business segments. For the nine months ended September 30, we have gained over 900 new customers and our number of active customers now exceed 3,700."

Mr. Edward Hu further commented, "During the Reporting Period, our success-based drug discovery unit filed INDs for 16 new-chemical-entities for domestic customers with the China National Medical Products Administration and obtained 20 CTAs. As of September 30, 2019, we have cumulatively submitted 71 new-chemical-entity IND filings with the NMPA for our customers and obtained 54 CTAs. As of September 30, 2019, our small molecule CDMO/CMO pipeline has grown to more than 900 active projects, including 40 projects in Phase III clinical trials and 17 in commercial manufacturing, and our cell and gene therapies CDMO business provided services for 33 clinical stage projects, including 24 projects in Phase I and 9 projects in Phase II/III. In September 2019, we also completed the issuance of USD 300 million zero-coupon convertible bonds, providing the Company with a strong balance sheet for investments, business expansion and potential M&A."

Dr. Ge Li, Chairman and CEO of WuXi AppTec, stated, "Our business model and the platform we have built continue to perform well. We continue to invest in new capabilities and capacities and believe these investments will allow the company to sustain our long term growth. We will continue to focus on enabling global partners and assisting them to bring the best medicines to patients in need, and to realize our vision that ‘every drug can be made and every disease can be treated’."

Third-Quarter 2019 IFRS Results

Revenue increased 34.7% year-over-year to RMB 3,384 million.
Gross profit increased 31.5% year-over-year to RMB 1,377 million. Gross profit margin was 40.7%, slightly lower than 41.7% in the three months ended September 30, 2018.[7]
EBITDA increased 22.0% Year-Over-Year to RMB 1,155 million.
Net profit attributable to owners of the Company increased 7.9% year-over-year to RMB 708 million. Net profit growth rate was slower than revenue growth rate, mainly due to a RMB 10 million gain in fair value of our investment portfolio for the third quarter of 2019, compared with a RMB 237 million gain in the same period last year which was primarily due to Hua Medicine and Unity Biotechnology stock price change after the IPO. Excluding the impact of changes in fair value of our investment portfolio, the net profit attributable to owners of the Company in the current period increased by 66.4% compared with the same period last year.
Third-Quarter 2019 Non-IFRS Results

Third-Quarter 2019 non-IFRS net profit attributable to owners of the Company increased 9.9% year-over-year to RMB 739 million. This adjusts for share-based compensation expenses, listing expenses and convertible bonds issuance expenses, distribution expenses for convertible bonds, foreign exchange-related effects and amortization of intangible assets acquired in business combinations.
Third-Quarter 2019 Adjusted Non-IFRS Results

Excluding realized/unrealized gains or losses from our venture investments and realized/unrealized gains or losses from our joint ventures, Third-Quarter 2019 adjusted non-IFRS net profit attributable to owners of the Company increased 50.2% year-over-year to RMB 664 million.
Year-to-Date 2019 IFRS Results

Revenue increased 34.1% year-over-year to RMB 9,279 million.
Gross profit increased 30.6% year-over-year to RMB 3,660 million. Gross profit margin was 39.5%, slightly lower than 40.5% in the nine months ended September 30, 2018.[8]
EBITDA increased 7.3% Year-Over-Year to RMB 2,914 million.
Net profit attributable to owners of the Company decreased 8.5% year-over-year to RMB 1,765 million, mainly due to a RMB 45 million loss in fair value of our investment portfolio for the first nine months of 2019, compared with a RMB 669 million gain in the same period last year which was primarily due to Hua Medicine and Unity Biotechnology stock price change after the IPO. Excluding the impact of changes in fair value of our investment portfolio, the net profit attributable to owners of the Company in the current period increased by 43.7% compared with the same period last year.
Year-to-Date 2019 Non-IFRS Results

Year-to-Date 2019 non-IFRS net profit attributable to owners of the Company decreased 3.9% year-over-year to RMB 1,952 million. This adjusts for share-based compensation expenses, listing expenses and convertible bonds issuance expenses, distribution expenses for convertible bonds, foreign exchange-related effects and amortization of intangible assets acquired in business combinations.
Year-to-Date 2019 Adjusted Non-IFRS Results

Excluding realized/unrealized gains or losses from our venture investments and realized/unrealized gains or losses from our joint ventures, Year-to-Date 2019 adjusted non-IFRS net profit attributable to owners of the Company increased 38.0% year-over-year to RMB 1,842 million.

ANI Pharmaceuticals Schedules Conference Call to Discuss Third Quarter and Year-to-Date 2019 Financial Results

On October 30, 2019 ANI Pharmaceuticals, Inc. (NASDAQ: ANIP) reported that the Company plans to release its third quarter and year-to-date 2019 financial results on Wednesday, November 6, 2019, before the opening of the U.S. financial markets (Press release, ANI Pharmaceuticals, OCT 30, 2019, View Source [SID1234550076]). The earnings press release will be accessible through the Investor Relations section of the Company’s website, www.anipharmaceuticals.com.

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Arthur S. Przybyl, President and Chief Executive Officer, and Stephen P. Carey, Vice President, Finance, and Chief Financial Officer, also plan to host a conference call to review those results starting at 10:30am Eastern Time on Wednesday, November 6, 2019. The call will be open to the public and can be accessed through a conference line by dialing (866) 776-8875. The conference ID is 2599456.

A recording of the conference call will be available within two hours of the completion of the call and will remain accessible for a period of seven days following the call. To access the replay, dial (800) 585-8367. The access code for the replay is 2599456.

PDL BioPharma to Announce Third Quarter 2019 Financial Results on November 6, 2019

On October 30, 2019 PDL BioPharma, Inc. ("PDL" or "the Company") (NASDAQ: PDLI) reported that it will release its third quarter 2019 financial results for the period ended September 30, 2019, on Wednesday, November 6, 2019, after market close (Press release, PDL BioPharma, OCT 30, 2019, View Source [SID1234550075]). PDL’s management will host a conference call and webcast that day at 4:30 p.m. Eastern time to discuss the operating and financial results and recent developments. A slide presentation relating to the call will be available via the webcast link on the PDL website at View Source

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Conference Call Details
To access the live conference call via phone, please dial (844) 535-4071 from the United States and Canada or (706) 679-2458 internationally. The conference ID is 3195828. Please dial in approximately 10 minutes prior to the start of the call. A telephone replay will be available for one week following the call and may be accessed by dialing (855) 859-2056 from the United States and Canada or (404) 537-3406 internationally. The replay passcode is 3195828.

To access the live and subsequently archived webcast of the conference call, go to the Company’s website and go to "Events & Presentations." Please connect to the website at least 15 minutes prior to the call to allow for any software download that may be necessary.

European Commission Approves Astellas’ XOSPATA ™ for Patients with Relapsed or Refractory Acute Myelogenous Leukemia, Identifying Mutations Using Invivoscribe’s LeukoStrat® CDx FLT3 Mutation Assay

On October 30, 2019 Invivoscribe Inc. reported that the European Commission (EC) has granted regulatory approval for the Astellas drug XOSPATA (gilteritinib) (Press release, Invivoscribe Technologies, OCT 30, 2019, View Source;825237203.html [SID1234550074]). This is a monotherapy for the treatment of adult patients with relapsed or refractory acute myeloid leukemia (AML) with FLT3 mutations ( FLT3 mut +), which discovers from the Invivo leukostrat CDx FLT3 mutation assay can be.

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The LeukoStrat test is available as a test menu service through the subsidiaries of Invivoscribe LabPMM LLC ( San Diego , California, USA ), LabPMM GmbH (Martinsried, Germany), and LabPMM GK ( Kawasaki, Japan ). Test kits of the LeukoStrat CDx FLT3 mutation assay are currently distributed in Europe, Japan , Switzerland and Australia and are expected to be available in the United States and China in the future .

Invivoscribe has developed the LeukoStrat CDx FLT3 Mutation Assay in collaboration with Astellas as a companion diagnostic to predict patient response to Astellas Pharma’s AOS drug XOSPATA (gilteritinib fumarate). The current approval is based on the results of the Phase 3 ADMIRAL study in which gilteritinib is compared to second-line chemotherapy in patients with relapsed or refractory FLT3mut + -AML was investigated. There was a significantly higher Overall Survival (OS) in patients treated with gilteritinib than those who received second-line chemotherapy. The mean OS for patients receiving gilteritinib was 9.3 months, compared to 5.6 months for patients treated with second-line chemotherapy alone.

With this milestone, the LeukoStrat CDx FLT3 Mutation Assay can continue to establish itself as an international gold standard for comprehensive FLT3 assessment of critically ill AML patients. This is especially true because this CDx can identify both ITD and TKD FLT3 mutations (including large internal tandem duplications) and is globally available.

This approval completes the series of regulatory approvals previously received by Invivoscribe for the LeukoStrat CDx FLT3 mutation assay as an adjunctive diagnostic for Astellas XOSPATA (gilteritinib fumarate), Novartis RYDAPT (midostaurine) and Daichi Sankyo quizartineib hydrochloride.

"The approval by the European Commission is a significant forest step for patients with relapsed or refractory FLT3 mutation-positive acute myeloid leukemia. Invivoscribe looks forward to additional treatment options that can extend the lives of patients, and the company looks forward to partnering with other pharmaceutical companies interested in using our Streamlined CDx program, whether its therapies for hematologic disease or cancer targeting solid tumors to accelerate drug approvals worldwide, "said Jeffrey Miller , CSO and CEO of Invivoscribe .

About the Invivoscribe LeukoStrat CDx FLT3 Mutation Assay
The LeukoStrat CDx FLT3 Mutation Assay is a PCR-based in vitro diagnostic test that incorporates internal tandem duplication (ITD) mutations and the D835 and I836 mutations in the Tyrosine kinase domain (TKD) can be detected in the FLT3 gene. The gene is derived from genomic DNA extracted from mononuclear cells derived from peripheral blood or bone marrow aspirate from patients diagnosed with acute myeloid leukemia.

The LeukoStrat CDx FLT3 Mutation Assay is used as a tool to evaluate patients with AML who are considering treatment with Midostaurin (United States, Europe, Switzerland and Australia).

The LeukoStrat CDx FLT3 Mutation Assay is used as a tool to evaluate patients with AML who are considering treatment with gilteritinib fumarate (United States, Europe and Japan ).

The LeukoStrat CDx FLT3 mutation assay is used as a tool to evaluate patients with AML who are considering treatment with quizartineib hydrochloride ( Japan ).

The globally standardized test includes software that interprets data and determines the respective mutant / wild-type signal quotient for ITD and TKD mutations. This extensively tested assay helps standardize the discovery of genetic mutations in the FLT3 gene, which is one of the major causes of mutations in acute myeloid leukemia (AML).

NuVasive Announces Third Quarter 2019 Financial Results

On October 30, 2019 NuVasive, Inc. (NASDAQ: NUVA), the leader in spine technology innovation, focused on transforming spine surgery with minimally disruptive, procedurally integrated solutions, reported financial results for the quarter ended September 30, 2019 (Press release, NuVasive, OCT 30, 2019, View Source [SID1234550073]).

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Third Quarter 2019 Highlights

Revenue increased 7.2% to $290.8 million, or 7.5% on a constant currency basis;
GAAP operating profit margin of 10.5%; Non-GAAP operating profit margin of 15.7%;
GAAP diluted earnings per share of $0.21; Non-GAAP diluted earnings per share of $0.59; and
Company raises full-year 2019 financial guidance.
"In the third quarter 2019, NuVasive grew at multiples of market, with revenue increasing 7.2% driven by nearly double-digit organic growth within U.S. Hardware," said J. Christopher Barry, chief executive officer of NuVasive. "In addition to strong topline results, our margin expansion demonstrates the ability to improve profitability with continued commitment to driving operational excellence. Based on the Company’s performance year to date, we are raising full-year 2019 financial guidance to reflect continued growth and confidence in the business."

A full reconciliation of GAAP to non-GAAP financial measures can be found in the tables of this news release.

Third Quarter 2019 Results
NuVasive reported third quarter 2019 total revenue of $290.8 million, a 7.2% increase compared to $271.3 million for the third quarter 2018. On a constant currency basis, third quarter 2019 total revenue increased 7.5% compared to the same period last year.

For the third quarter 2019, both GAAP and non-GAAP gross profit was $213.8 million and GAAP and non-GAAP gross margin was 73.5%. These results compared to GAAP and non-GAAP gross profit of $197.1 million and $197.4 million, respectively, and GAAP and non-GAAP gross margin of 72.7% and 72.8%, respectively, for the third quarter 2018.

The Company reported GAAP net income of $11.0 million, or diluted earnings per share of $0.21, for the third quarter 2019 compared to a GAAP net income of $15.9 million, or diluted earnings per share of $0.30, for the third quarter 2018. On a non-GAAP basis, the Company reported net income of $30.9 million, or diluted earnings per share of $0.59, for the third quarter 2019 compared to net income of $29.5 million, or diluted earnings per share of $0.56, for the third quarter 2018.

Annual Financial Guidance for 2019
The Company raised its full-year 2019 financial guidance as a result of strong financial performance to date.

Prior guidance reflects the range provided July 30, 2019. Current guidance reflects the range provided October 30, 2019.

Constant currency is a measure that adjusts US GAAP revenue for the impact of currency over the same period in the prior year.

The Company updates full-year 2019 revenue to approximately $1.16 billion, compared with prior guidance of $1.14 billion to $1.16 billion, which now includes approximately $6 million in year-over-year currency headwinds compared with prior guidance of $5 million. This reflects reported growth in the range of 5.1% to 5.8%, compared with prior guidance of 3.4% to 5.4%. Revenue growth on a constant currency basis is in the range of 5.6% to 6.3%, compared with prior guidance of 3.8% to 5.8%;
Non-GAAP operating profit margin of 15.5% to 15.9%, compared with prior guidance of 15.3% to 15.7%;
Non-GAAP diluted earnings per share in a range of $2.35 to $2.40, compared with prior guidance of $2.25 to $2.35;
Adjusted EBITDA margin of 25.0% to 25.4%, compared with prior guidance of 25.5% to 25.9%; and
Non-GAAP effective tax expense rate of approximately 23%.
Organizational Structure
NuVasive announced today a new organizational structure, effective January 1, 2020, to further build upon its success and advance the Company’s five-year strategic plan.

"We are implementing organizational structure changes to bring together the commercial, product and technology teams under one function and to establish a new global operations function focused on supply chain and logistics," continued Barry. "This is a natural progression aligned with our recently announced five-year strategy and our purpose to transform surgery, advance care and change lives."

The new organizational structure combines customer-facing and innovation activities under a single function led by the Company’s president, Matt Link. A new global operations function, including supply chain, distribution, manufacturing, quality assurance and real estate & facilities, will be led by Dale Wolf, NuVasive’s current head of manufacturing.

Supplementary Financial Information
For additional financial detail, please visit the Investor Relations section of the Company’s website at www.nuvasive.com to access Supplementary Financial Information.

Reconciliation of Full Year EPS Guidance

Items may not foot due to rounding.

Prior guidance reflects the range provided July 30, 2019. Current guidance reflects the range provided October 30, 2019.

Effective tax expense rate of ~24% applied to GAAP earnings and ~23% applied to Non-GAAP earnings.

Effective tax expense rate of ~26% applied to GAAP earnings and ~23% applied to Non-GAAP earnings.

Costs related to acquisition, integration and business transition activities which include severance, relocation, consulting, leasehold exit costs, third party merger and acquisitions costs, contingent consideration fair value adjustments, and other costs directly associated with such activities.

Represents costs associated with non-cash purchase accounting adjustments, such as acquired inventory fair market value adjustments, which are amortized over the period in which underlying products are sold.

Represents the loss recorded in connection with the settlement of the Madsen Medical, Inc. litigation matter, as well as expenses associated with ongoing litigation with a former Board member and his current employer related to various matters, including infringement of the Company’s intellectual property.

Non-recurring consulting fees associated with the implementation of our state tax-planning strategy.

Purchase of an in-process research and development asset which had no future alternative use.

Costs related to updating our quality system, product labeling, asset write-offs and product remanufacturing to comply with European medical device regulation.

The impact on results from taxes include tax affecting the adjustments above at the statutory rate as well as taking into account discrete items and including those discrete items in the annual effective tax rate calculation. The Company also includes those adjustments that would have benefited the tax rate in lieu of the above adjustments as part of the Company’s tax filings. The impact of the changes to the tax rate results in an annual rate of ~43% benefit on a GAAP basis and ~18% on a non-GAAP basis in 2018.

Adjusted non-GAAP diluted WASO excludes the impact of dilutive convertible notes and warrants for which the Company is economically hedged through its anti-dilutive bond hedge arrangements.

Reconciliation of Non-GAAP Operating Margin %

Items may not foot due to rounding.

Prior guidance reflects the range provided July 30, 2019. Current guidance reflects the range provided October 30, 2019.

Represents costs associated with non-cash purchase accounting adjustments, such as acquired inventory fair market value adjustments, which are amortized over the period in which underlying products are sold.

Non-recurring consulting fees associated with the implementation of our state tax-planning strategy.

Expenses associated with ongoing litigation with a former Board member and his current employer related to various matters, including infringement of the Company’s intellectual property.

Represents the loss recorded in connection with the settlement of the Madsen Medical, Inc. litigation matter.

Purchase of an in-process research and development asset which had no future alternative use.

Costs related to updating our quality system, product labeling, asset write-offs and product remanufacturing to comply with European medical device regulation.

Costs related to acquisition, integration and business transition activities which include severance, relocation, consulting, leasehold exit costs, third party merger and acquisitions costs, contingent consideration fair value adjustments, and other costs directly associated with such activities.

Reconciliation of EBITDA Margin %

Items may not foot due to rounding.

Effective tax expense rate of ~43% benefit applied to GAAP earnings and ~18% applied to Non-GAAP earnings.

Effective tax expense rate of ~24% applied to GAAP earnings and ~23% applied to Non-GAAP earnings.

Effective tax expense rate of ~26% applied to GAAP earnings and ~23% applied to Non-GAAP earnings.

Prior guidance reflects the range provided July 30, 2019. Current guidance reflects the range provided October 30, 2019.

Costs related to acquisition, integration and business transition activities which include severance, relocation, consulting, leasehold exit costs, third party merger and acquisitions costs, contingent consideration fair value adjustments, and other costs directly associated with such activities.

Represents costs associated with non-cash purchase accounting adjustments, such as acquired inventory fair market value adjustments, which are amortized over the period in which underlying products are sold.

Represents the loss recorded in connection with the settlement of the Madsen Medical, Inc. litigation matter, as well as expenses associated with ongoing litigation with a former Board member and his current employer related to various matters, including infringement of the Company’s intellectual property.

Non-recurring consulting fees associated with the implementation of our state tax-planning strategy.

Purchase of an in-process research and development asset which had no future alternative use.

Charges represent the costs specific to updating our quality system, product labeling, asset write-offs and product remanufacturing to comply with European medical device regulation.

Reconciliation of GAAP to Non-GAAP Information
Management uses certain non-GAAP financial measures such as non-GAAP earnings per share, non-GAAP net income, non-GAAP operating expenses and non-GAAP operating profit margin, which exclude amortization of intangible assets, business transition costs, purchased in-process research and development, one-time restructuring and related items in connection with acquisitions, investments and divestitures, non-recurring consulting fees, certain litigation expenses and settlements, certain European medical device regulation costs, gains and losses from strategic investments, and non-cash interest expense (excluding debt issuance cost). Management also uses certain non-GAAP measures which are intended to exclude the impact of foreign exchange currency fluctuations. The measure constant currency utilizes an exchange rate that eliminates fluctuations when calculating financial performance numbers. The Company also uses measures such as free cash flow, which represents cash flow from operations less cash used in the acquisition and disposition of capital. Additionally, the Company uses an adjusted EBITDA measure which represents earnings before interest, taxes, depreciation and amortization and excludes the impact of stock-based compensation, business transition costs, purchased in-process research and development, one-time restructuring and related items in connection with acquisitions, investments and divestitures, non-recurring consulting fees, certain litigation expenses and settlements, certain European medical device regulation costs, gains and losses on strategic investments, and other significant one-time items.

Management calculates the non-GAAP financial measures provided in this earnings release excluding these costs and uses these non-GAAP financial measures to enable it to further and more consistently analyze the period-to-period financial performance of its core business operations. Management believes that providing investors with these non-GAAP measures gives them additional information to enable them to assess, in the same way management assesses, the Company’s current and future continuing operations. These non-GAAP measures are not in accordance with, or an alternative for, GAAP, and may be different from non-GAAP measures used by other companies. Set forth below are reconciliations of the non-GAAP financial measures to the comparable GAAP financial measure.

For the Three Months Ended September 30, 2019

Reconciliation of GAAP to Non-GAAP Financial Measures

Represents expenses associated with ongoing litigation with a former Board member and his current employer related to various matters, including infringement of the Company’s intellectual property.

Costs related to acquisition, integration and business transition activities which include severance, relocation, consulting, leasehold exit costs, third party merger and acquisitions costs, contingent consideration fair value adjustments, and other costs directly associated with such activities.

Represents costs specific to updating our quality system, product labeling, asset write-offs and product remanufacturing to comply with European medical device regulation.

Represents the impact from tax affecting the adjustments above at their statutory tax rate. As of October 30, 2019, the Company estimated an annual tax rate of ~26% on a GAAP basis and ~23% on a non-GAAP basis.

Adjusted non-GAAP diluted WASO excludes the impact of dilutive convertible notes and warrants for which the Company is economically hedged through its anti-dilutive bond hedge arrangements.

For the Nine Months Ended September 30, 2019

Reconciliation of GAAP to Non-GAAP Financial Measures

Represents expenses associated with ongoing litigation with a former Board member and his current employer related to various matters, including infringement of the Company’s intellectual property.

Costs related to acquisition, integration and business transition activities which include severance, relocation, consulting, leasehold exit costs, third party merger and acquisitions costs, contingent consideration fair value adjustments, and other costs directly associated with such activities.

Represents costs specific to updating our quality system, product labeling, asset write-offs and product remanufacturing to comply with European medical device regulation.

Represents the impact from tax affecting the adjustments above at their statutory tax rate. As of October 30, 2019, the Company estimated an annual tax rate of ~26% on a GAAP basis and ~23% on a non-GAAP basis.

Adjusted non-GAAP diluted WASO excludes the impact of dilutive convertible notes and warrants for which the Company is economically hedged through its anti-dilutive bond hedge arrangements.

For the Three Months Ended September 30, 2018

Reconciliation of GAAP to Non-GAAP Financial Measures

Represents costs associated with non-cash purchase accounting adjustments, such as acquired inventory fair market value adjustments, which are amortized over the period in which underlying products are sold.

Represents expenses associated with ongoing litigation with a former Board member and his current employer related to various matters, including infringement of the Company’s intellectual property.

Costs related to acquisition, integration and business transition activities which include severance, relocation, consulting, leasehold exit costs, third party merger and acquisitions costs, contingent consideration fair value adjustments, and other costs directly associated with such activities.

Purchase of an in-process research and development asset which had no future alternative use.

Represents the impact from tax affecting the adjustments above at their statutory tax rate. As of October 30, 2018, the Company estimated an annual tax rate of ~18% on a GAAP basis and ~21% on a non-GAAP basis.

Adjusted non-GAAP diluted WASO excludes the impact of dilutive convertible notes and warrants for which the Company is economically hedged through its anti-dilutive bond hedge arrangements.

Represents costs associated with non-cash purchase accounting adjustments, such as acquired inventory fair market value adjustments, which are amortized over the period in which underlying products are sold.

Non-recurring consulting fees associated with the implementation of our state tax-planning strategy.

Represents the loss recorded in connection with the settlement of the Madsen Medical, Inc. litigation matter, as well as expenses associated with ongoing litigation with a former Board member and his current employer related to various matters, including infringement of the Company’s intellectual property.

Costs related to acquisition, integration and business transition activities which include severance, relocation, consulting, leasehold exit costs, third party merger and acquisitions costs, contingent consideration fair value adjustments, and other costs directly associated with such activities.

Purchase of an in-process research and development asset which had no future alternative use.

Represents the impact from tax affecting the adjustments above at their statutory tax rate. As of October 30, 2018, the Company estimated an annual tax rate of ~18% on a GAAP basis and ~21% on a non-GAAP basis.

Adjusted non-GAAP diluted WASO excludes the impact of dilutive convertible notes and warrants for which the Company is economically hedged through its anti-dilutive bond hedge arrangements.

Investor Conference Call
NuVasive will hold a conference call today at 4:30 p.m. ET / 1:30 p.m. PT to discuss the results of its financial performance for the third quarter 2019. The dial-in numbers are 1-877-407-9039 for domestic callers and 1-201-689-8470 for international callers. A live webcast of the conference call will be available online from the Investor Relations page of the Company’s website at www.nuvasive.com. After the live webcast, the call will remain available on NuVasive’s website through November 29, 2019. In addition, a telephone replay of the call will be available until November 6, 2019. The replay dial-in numbers are 1-844-512-2921 for domestic callers and 1-412-317-6671 for international callers. Please use pin number: 13695343.