On September 10, 2019 Caris Life Sciences, a leading innovator in molecular science focused on fulfilling the promise of precision medicine, reported that Brian J. Brille, Vice Chairman of the Company, will present at the 17th Annual Morgan Stanley Global Healthcare Conference on Tuesday, September 10, 2019, at 12:55 p.m. Eastern Time (Press release, Caris Life Sciences, SEP 10, 2019, View Source [SID1234539423]). The conference is being held at The Grand Hyatt Hotel in New York City.

Schedule your 30 min Free 1stOncology Demo!
Discover why more than 1,500 members use 1stOncology™ to excel in:

Early/Late Stage Pipeline Development - Target Scouting - Clinical Biomarkers - Indication Selection & Expansion - BD&L Contacts - Conference Reports - Combinatorial Drug Settings - Companion Diagnostics - Drug Repositioning - First-in-class Analysis - Competitive Analysis - Deals & Licensing

                  Schedule Your 30 min Free Demo!

Mr. Brille will provide an overview of the business and discuss recent corporate achievements that position Caris to further extend its leadership in the market, in addition to taking questions from the audience.

Investors attending the conference who would like to schedule a one-on-one meeting with Caris executives may do so by contacting their Morgan Stanley representative.

On September 10, 2019 Kindred Biosciences, Inc. (NASDAQ: KIN), a commercial-stage biopharmaceutical company developing novel drugs and biologics, reported that it has been selected by the National Cancer Institute (NCI) as one of three contractors in response to the solicitation for the PREVENT Cancer Preclinical Drug Development Program (PREVENT): Current Good Manufacturing Practice (cGMP) Production of Vaccines and Biologicals for Cancer Prevention (cGMP Pool) (Press release, Kindred Healthcare, SEP 10, 2019, View Source [SID1234539421]). As a cGMP pool contractor, KindredBio is eligible to provide manufacturing, formulation and analytical services to meet the needs of the PREVENT pipeline.

Schedule your 30 min Free 1stOncology Demo!
Discover why more than 1,500 members use 1stOncology™ to excel in:

Early/Late Stage Pipeline Development - Target Scouting - Clinical Biomarkers - Indication Selection & Expansion - BD&L Contacts - Conference Reports - Combinatorial Drug Settings - Companion Diagnostics - Drug Repositioning - First-in-class Analysis - Competitive Analysis - Deals & Licensing

                  Schedule Your 30 min Free Demo!

PREVENT is an NCI-supported venture to advance preclinical development of innovative cancer prevention interventions and biomarkers towards clinical applications. A maximum amount of $49.95 million will be shared across three contract pools, one of which is the cGMP manufacturing pool. Within the cGMP pool, KindredBio is one of three contractors selected for award. The contract term is four years, with specific amounts based on individual task order awards yet to be determined.

"This selection is a validation of our manufacturing and project management expertise, and we look forward to working with the NCI on this important program," said Richard Chin, CEO of KindredBio.

KindredBio operates a state-of-the-art biological development and cGMP manufacturing facility in Burlingame, CA, and recently completed construction on a 180,000 square foot large scale cGMP manufacturing facility in Elwood, KS.

The company’s core expertise includes protein engineering, cell line development, master cell banking, process development, assay development, stability testing, and cGMP clinical and commercial manufacturing. KindredBio’s biologics team comprises experts in product development, manufacturing, quality control and quality assurance personnel, and is supported by a strong project management organization.

For additional information on PREVENT, please click here. Task orders awarded to KindredBio are expected to be conducted at the company’s cGMP manufacturing facility in Burlingame, CA.

This project has been funded in whole or in part with Federal funds from the National Cancer Institute, National Institutes of Health, Department of Health and Human Services, under Contract No. 75N91019D00027.

On September 10, 2019 RegeneRx Biopharmaceuticals, Inc. (OTCQB: RGRX) ("the Company" or "RegeneRx"), a clinical-stage drug development company focused on tissue protection, repair and regeneration, reported that J.J. Finkelstein, President and Chief Executive Officer, will present a corporate update at the Fall Investor Summit on September 17, 2019, at 8:30 a.m. ET in New York City (Press release, RegeneRx Biopharmaceuticals, SEP 10, 2019, View Source [SID1234539420]). The presentation will be webcast and can be accessed by the following link: View Source A slide presentation will also be available on the Company’s website at: View Source

Schedule your 30 min Free 1stOncology Demo!
Discover why more than 1,500 members use 1stOncology™ to excel in:

Early/Late Stage Pipeline Development - Target Scouting - Clinical Biomarkers - Indication Selection & Expansion - BD&L Contacts - Conference Reports - Combinatorial Drug Settings - Companion Diagnostics - Drug Repositioning - First-in-class Analysis - Competitive Analysis - Deals & Licensing

                  Schedule Your 30 min Free Demo!

On September 10, 2019 Linnaeus Therapeutics, Inc. ("Linnaeus"), a privately held biopharmaceutical company focused on the development and commercialization of novel, small molecule oncology therapeutics, reported that its scientific cofounder, Todd Ridky, MD, PhD, Assistant Professor of Dermatology at the Perelman School of Medicine at the University of Pennsylvania, presented new findings from his research team on a new potential therapeutic target for pancreatic cancer at the American Association for Cancer Research (AACR) (Free AACR Whitepaper) Special Conference on Pancreatic Cancer: Advances in Science and Clinical Care, which took place September 6-9, 2019, at the Westin Copley Place in Boston, Massachusetts (Press release, Linnaeus Plant Sciences, SEP 10, 2019, View Source [SID1234539419]).

Schedule your 30 min Free 1stOncology Demo!
Discover why more than 1,500 members use 1stOncology™ to excel in:

Early/Late Stage Pipeline Development - Target Scouting - Clinical Biomarkers - Indication Selection & Expansion - BD&L Contacts - Conference Reports - Combinatorial Drug Settings - Companion Diagnostics - Drug Repositioning - First-in-class Analysis - Competitive Analysis - Deals & Licensing

                  Schedule Your 30 min Free Demo!

The poster presentation, entitled "Pharmacologic activation of G protein-coupled estrogen receptor inhibits pancreatic ductal adenocarcinoma" was authored by Natale, et al. Data from preclinical mouse pancreatic cancer models show that tumors regress, tumor growth is inhibited, and some animals experience a complete cure after treatment by a synthetic small molecule that activates a nonclassical estrogen receptor called the G protein-coupled estrogen receptor (GPER) on tumor cells. The GPER agonist also markedly increases the efficacy of anti–PD-1 targeted immunotherapy.

The work extends earlier studies from the Ridky lab showing that GPER activation inhibits melanoma. Together these studies likely help explain the mechanism underlying the decades old observation that female sex and a history of previous pregnancy are associated with improved cancer outcomes.

"It’s exciting to learn that the anticancer activity we observed with these GPER-targeted agents in preclinical melanoma models extends to other cancer types and that these agents have a therapeutic synergy with modern immunotherapy." said Dr. Ridky.

"These data clearly demonstrate that the GPER agonist, LNS8801, has therapeutic efficacy in murine models of difficult-to-treat cancer, and we are excited to begin human testing in our phase 1b clinical trial in the coming weeks," commented Patrick Mooney, MD, Chief Executive Officer of Linnaeus.

On September 10, 2019 Clover Biopharmaceuticals, a biotechnology company focused on developing novel and transformative biologic therapies, reported that the first patient was dosed in a Phase I trial of SCB-313, an investigational fully-human TRAIL-Trimer fusion protein, in China for the treatment of cancer patients with peritoneal carcinomatosis (Press release, Clover Biopharmaceuticals, SEP 10, 2019, View Source [SID1234539418]).

Schedule your 30 min Free 1stOncology Demo!
Discover why more than 1,500 members use 1stOncology™ to excel in:

Early/Late Stage Pipeline Development - Target Scouting - Clinical Biomarkers - Indication Selection & Expansion - BD&L Contacts - Conference Reports - Combinatorial Drug Settings - Companion Diagnostics - Drug Repositioning - First-in-class Analysis - Competitive Analysis - Deals & Licensing

                  Schedule Your 30 min Free Demo!

"Peritoneal carcinomatosis has historically posed significant challenges for both patients and clinicians, and with no efficacious therapies currently available, it remains a high unmet medical need for many cancer patients worldwide. My team and I look forward to evaluating SCB-313 as a potential new therapy for the treatment of cancer patients with peritoneal carcinomatosis." said Dr. Yan Li, Director of Department of Peritoneal Surgical Oncology at Beijing Shijitan Hospital and Principal Investigator of the trial.

The Phase I, open-label, dose escalation trial in China is designed to assess the safety, tolerability, pharmacokinetics and preliminary efficacy of intraperitoneally administered SCB-313 as a single-agent for the treatment of peritoneal carcinomatosis.

"Since China has the largest global incidence of gastrointestinal cancers, which often cause peritoneal carcinomatosis, we are extremely excited about the initiation of the SCB-313 study in China. Now that SCB-313 has successfully initiated clinical studies evaluating SCB-313 in multiple countries, Clover hopes to bring this novel and potentially first-in-class therapy to patients worldwide," said Dr. Min Dong, Executive Vice President, Global Clinical Development at Clover.

"TRAIL has long been considered a tantalizing target for cancer therapy because it can induce apoptosis in a tumor-specific manner across many different tumor types. SCB-313, which utilizes our proprietary Trimer-Tag© technology, is able to potently and uniquely target this trimerization-dependent pathway," said Dr. Peng Liang, co-founder, Chairman and President of Clover. "We believe that SCB-313 has the potential to be a best-in-class TRAIL-based therapy based on our R&D results to date, and in the months ahead, we look forward to initiating multiple new clinical studies for the treatment of intracavitary cancers."